Stroke risk associated with chronic kidney disease
https://doi.org/10.21886/2308-6424-2025-13-4-97-106
Abstract
Chronic kidney disease (CKD) is the most significant risk factor in the development of stroke; the latter remains the leading cause of morbidity and mortality globally. CKD patients, especially at the end-stage renal failure and on dialysis, have a very high risk of stroke by 5 – 30 times, with a mortality rate reaching almost 90%. CKD is associated with both ischemic and hemorrhagic stroke. In addition to general risk factors, increased cerebrovascular risk is due to several mechanisms associated with CKD, such as platelet dysfunction, blood clotting disorders, endothelial dysfunction, inflammation, and an increased risk of atrial fibrillation. In addition, CKD can significantly affect the effectiveness of stroke treatment and prevention. Therefore, it is important to study the factors contributing to the development of stroke in this vulnerable population group to apply preventive strategies more effectively. This article examines the epidemiology and pathophysiology of the association between CKD and stroke, as well as the impact of CKD on stroke outcomes. The study aimed to review scientific articles published over the past twenty years on the relationship between CKD and stroke risk. To achieve this objective, a search was used for the keywords «chronic kidney disease», «stroke», «risk», «stroke risk factors» in the databases PubMed, Google Scholar and eLibrary.
About the Authors
F. A. Yusupov
Osh State University
Kyrgyzstan
Kyrgyzstan
Furkat A. Yusupov – Dr.Sc.(Med), Full Prof.
Osh
A. F. Yusupov
Osh State University
Kyrgyzstan
Kyrgyzstan
Abdulhakim F. Yusupov
Osh
A. A. Yuldashev
Osh State University
Kyrgyzstan
Kyrgyzstan
Akmal A. Yuldashev
Osh
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Yusupov F.A., Yusupov A.F., Yuldashev A.A. Stroke risk associated with chronic kidney disease. Urology Herald. 2025;13(4):97-106. (In Russ.) https://doi.org/10.21886/2308-6424-2025-13-4-97-106
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