The use of DNA semen fragmentation in andrological practice
https://doi.org/10.21886/2308-6424-2019-7-1-7-11
Abstract
Introduction. Despite numerous methods of treating infertility including methods of assisted reproductive technology a significant proportion of patients remains with infertility.
Purpose of the study. Improving the efficiency of the diagnosis of couples with two or more missed pregnancies in history.
Materials and methods. We examined 38 patients aged from 22 to 38 years with a diagnosis of infertility.
Results. The most common form of prospermia with missed abortion is teratozoospermia (53%), asthenozoospermia occurs in 21% of cases, asthenoteratozoospermia - 8%. Normosaospermia is recorded in 18% of patients. When determining the DNA of semen fragmentation, it turns out that only about 20% of the subjects do not have this pathology.
Findings. The results indicate the need for further study of the contribution of prospermia, and in particular teratozoospermia, and DNA disruption of semen fragmentation to reproductive loss.
About the Author
N. E. Avadieva
Rostov-on-Don City Polyclinic №10
Russian Federation
Russian Federation
Nadezhda E. Avadieva - M.D., Ph.D. (M); Urologist.
Rostov-on-Don
References
1. WHO Manual for the Standardized Investigation, Diagnosis and Management of the Infertile Ma le. Cambridge. Cambridge University Press; 2009.
2. A Jungwirth (Ed.), T Diemer, GR Dohle et al. Guidelines on Male Infertility. European Association of Urology; 2015.
3. Oumaima A, Tesnim A, Zohra H, Amira S, Ines Z, Sana C, In-tissar G, Lobna E, Ali J, Meriem M. Investigation on the origin of sperm morphological defects: oxidative attacks, chroma-ti n immaturity, and DNA fragmentation. Environ Sci Pollut Res Int. 2018;25(14):13775-13786. DOI: 10.1007/s11356-018-1417-4
4. Ibishev KhS, Magomedov GA, Ryabenchenko NN. Role of human papillomavirus infection in male infertility. Vopr. urol. androl. (Urology and Andrology). 2018;6(3):22-27. (In Russ.). DOI: 10.20953/2307-6631-2018-3-22-27
5. Ibishev KhS, Kogan MI, Magomedov RG, Krainy PA. Modern View on the Pathogenetic Foundations of the Chronic Recurrent Bacterial Prostatitis. Effectivnaya farmakoterapiya. 2017;42:6-10. (in Russ.). eLIBRARY ID: 30798487
6. Nieschlag E, Behre HM, Nieschlag S (Ed). Andrology: Male Reproductive Health and Disfunction. 3rd. 2010.
7. Vinogradov IV eds. Rukovodstvo po klinicheskoy andrologii. 2018. (in Russ.)
8. Eisenberg ML, Sapra KJ, Kim SD, Chen Z, Buck Louis GM. Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertil Steril. 2017;108(4):613-619. DOI: 10.1016/j.fertnstert.2017.07.008.
9. Carlini T, Paoli D, Pelloni M, Faja F, Dal Lago A, Lombardo F, Lenzi A, Gandini L. Sperm DNA fragmentati on in Italian couples with recurrent pregnancy loss. Reprod Biomed Online. 2017;34(1):58-65. DOI: 10.1016/j.rbmo.2016.09.014.
10. Bareh GM, Jacoby E, Binkley P, Chang TC, Schenken RS, Robinson RD. Sperm deoxyribonucleic acid fragmentation assessment in normozoospermic male partners of couples with unexplained recurrent pregnancy loss: a prospective study. Fertil Steril. 2016;105(2):329-36.e1. DOI: 10.1016/j.fertnstert.2015.10.033
11. Agarwal A, Prabakaran S, Allamaneni SS. Relationship between oxidative stress, varicocele and inferti lity: a metaanalysis. Reprod Biomed Online. 2006;12(5):630-633. PMID: 16790111
12. Tesarik J, Mendoza C. Effects of exogenous LH administration during ovarian stimulation of pituitary down-regulated young oocyte donors on oocyte yield and developmental competence. Hum Reprod. 2002;17(12):3129-3137. PMID: 12456612
13. Benchaib M, Braun V, Lornage J, Hadj S, Salle B, Lejeune H, Guerin JF. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Re-prod. 2003;18(5):1023-1028. PMID: 12721180
14. Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2014;(12):CD007411. DOI: 10.1002/14651858.CD007411.pub3
Review
For citations:
Avadieva N.E. The use of DNA semen fragmentation in andrological practice. Urology Herald. 2019;7(1):7-11. (In Russ.) https://doi.org/10.21886/2308-6424-2019-7-1-7-11
Views:
1836
Email this article 
