Prevalence and prediction of urinary incontinence after transurethral surgery for prostatic hyperplasia: evaluation of different approaches
https://doi.org/10.21886/2308-6424-2026-14-2-102-111
Abstract
Introduction. Transurethral resection of the prostate (TURP) has historically been regarded as the gold standard surgical treatment for benign prostatic hyperplasia (BPH), although over the past two decades the spectrum of transurethral procedures has expanded substantially with the introduction of various enucleation techniques. Despite the favourable safety profile of contemporary technologies, urinary incontinence (UI) remains one of the most clinically significant complications following transurethral surgery for BPH.
Objective. To summarise current data on the incidence and classification of different forms of UI after transurethral procedures for BPH; to analyse key risk factors, and to critically appraise existing predictive models and nomograms, with a view to outlining prospects for their further refinement and clinical implementation.
Materials & methods. A literature search was performed in the PubMed and Elibrary.ru databases for the period from 1999 to 2026, restricted to publications in Russian and English.
Results. A central challenge in studying postoperative UI is the absence of a single standardised definition, with clinical studies employing both subjective measures (patient‑reported symptoms and validated questionnaires such as ICIQ‑SF, IPSS, UCLA‑PCI) and objective metrics (pad counts and 24‑hour pad tests). The principal mechanism of stress UI is injury to the external urethral sphincter at the prostatic apex and verumontanum due to mechanical trauma during enucleation and urethral dilation, whereas urgency UI is attributed to pre‑existing detrusor overactivity from chronic obstruction and to postoperative inflammation and bladder irritation, including potential thermal effects. Proposed risk factors for UI include age, body mass index, operative technique, prostate volume and growth pattern, urethral anatomy, urodynamic parameters, and surgeon experience. Based on these predictors, several prognostic models and nomograms have been developed in recent years to enable individualised assessment of postoperative UI risk and to improve preoperative counselling and surgical decision‑making.
Conclusion. Reported UI rates vary widely due to heterogeneity in definitions and assessment methods, highlighting the need for user‑friendly tools that facilitate implementation of predictive models in routine practice.
Keywords
About the Authors
E. A. MeshcheriakovaRussian Federation
Elena A. Meshcheriakova
Moscow
Competing Interests:
The authors declare no conflicts of interest
R. R. Neftulaev
Russian Federation
Renat R. Neftulaev
Moscow
Competing Interests:
The authors declare no conflicts of interest
O. Yu. Nesterova
Russian Federation
Olga Yu. Nesterova — Cand.Sc.(Med)
Moscow
Competing Interests:
The authors declare no conflicts of interest
A. A. Strigunov
Russian Federation
Andrey A. Strigunov — Cand.Sc.(Med)
Moscow
Competing Interests:
The authors declare no conflicts of interest
M. Yu Nikolaev
Russian Federation
Mikhail Yu. Nikolaev
Moscow
Competing Interests:
The authors declare no conflicts of interest
K. M. Yusupov
Russian Federation
Karim M. Yusupov
Moscow
Competing Interests:
The authors declare no conflicts of interest
D. A. Okhobotov
Russian Federation
Dmitry A. Okhobotov — Dr.Sc.(Med)
Moscow
Competing Interests:
The authors declare no conflicts of interest
N. I. Sorokin
Russian Federation
Nikolay I. Sorokin — Dr.Sc.(Med)
Moscow
Competing Interests:
The authors declare no conflicts of interest
A. A. Kamalov
Russian Federation
Armais A. Kamalov — Dr.Sc.(Med), Full Prof., Acad. of the RAS
Moscow
Competing Interests:
The authors declare no conflicts of interest
References
1. Schally AV, Theodoropoulos G, Sha W, Vidaurre I, Wangpaichitr M. A 50-year journey in the development of treatment for benign prostatic hyperplasia. NPJ Aging. 2025;11(1):41. DOI: 10.1038/s41514-025-00231-2
2. Porto JG, Bhatia AM, Bhat A, Suarez Arbelaez MC, Blachman-Braun R, Shah K, Malpani A, Lopategui D, Herrmann TRW, Marcovich R, Shah HN. Evaluating transurethral resection of the prostate over twenty years: a systematic review and meta-analysis of randomized clinical trials. World J Urol. 2024;42(1):639. DOI:10.1007/s00345-024-05332-3
3. Morozov A, Taratkin M, Shpikina A, Ehrlich Y, McFarland J, Dymov A, Kozlov V, Fajkovic H, Rivas JG, Lusuardi L, Teoh JY, Herrmann T, Baniel J, Enikeev D. Comparison of EEP and TURP long-term outcomes: systematic review and meta-analysis. World J Urol. 2023;41(12):3471-3483. DOI: 10.1007/s00345-023-04666-8
4. Rakhimov S.A., Feofilov I.V., Arbuzov I.A. Laser technologies in surgery for benign prostate hyperplasia. Urology Herald. 2024;12(1):80-90. (In Russian). DOI: 10.21886/2308-6424-2024-12-1-80-90
5. He M, Mao C, Shu Y, Liu X. Urinary Incontinence Following Transurethral Prostatectomy: Current Status and Nursing Strategies. Biol Res Nurs. 2025;27(3):423-429. DOI: 10.1177/10998004251318909
6. Bernardes MFVG, Chagas SC, Izidoro LCR, Veloso DFM, Chianca TCM, Mata LRFPD. Impact of urinary incontinence on the quality of life of individuals undergoing radical prostatectomy. Rev Lat Am Enfermagem. 2019;27:e3131. doi: 10.1590/1518-8345.2757.3131. Erratum in: Rev Lat Am Enfermagem. 2019;27:e3244. DOI: 10.1590/1518-8345.0000.3244
7. Yang M, Huang Y, Gao F, He L, Yu X, Yu Q. Meta-analysis of postoperative urinary incontinence incidence and risk factors in HoLEP. Ther Adv Urol. 2024;16:17562872241281578. DOI: 10.1177/17562872241281578
8. Fan X, Zhang J, Zhu H, Huang F, Shadike A, Jiang C. Predictive factors of stress urinary incontinence after Holmium Laser Enucleation of the Prostate: a magnetic resonance imaging-based retrospective study. Transl Androl Urol. 2024;13(9):1775-1785. DOI: 10.21037/tau-24-71
9. Holze S, Kuntze AS, Mende M, Neuhaus P, Truss MC, Do HM, Dietel A, Franz T, Stolzenburg JU. Assessment of different continence definitions in the context of the randomized multicenter prospective LAP01 trial-Does the best definition change over time? Eur J Med Res. 2024;29(1):58. DOI: 10.1186/s40001-024-01662-5
10. Holze S, Mende M, Healy KV, Koehler N, Gansera L, Truss MC, Rebmann U, Degener S, Stolzenburg JU. Comparison of various continence definitions in a large group of patients undergoing radical prostatectomy: a multicentre, prospective study. BMC Urol. 2019;19(1):70. DOI: 10.1186/s12894-019-0500-6
11. Ceraolo CA, Winzer BM, Fairbourn JD, Phan D, Jain RK, Quarrier SO. “Defining the Drip: A Systematic Review of Incontinence Definitions and Predictors Following HoLEP”. Curr Urol Rep. 2025;26(1):72. DOI: 10.1007/s11934-025-01296-y
12. Petros P, Quaghebeur J, Wyndaele JJ. An anatomical pathogenesis of lower urinary tract definitions from the 2002 ICS report symptoms, conditions, syndromes, urodynamics. Neurourol Urodyn. 2022;41(3):740- 755. doi: 10.1002/nau.24889. Epub 2022 Feb 16. Erratum in: Neurourol Urodyn. 2023;42(5):1169. DOI: 10.1002/nau.25177
13. Namiki S, Takegami M, Kakehi Y, Suzukamo Y, Fukuhara S, Arai Y. Analysis linking UCLA PCI with Expanded Prostate Cancer Index Composite: an evaluation of health related quality of life in Japanese men with localized prostate cancer. J Urol. 2007;178(2):473-7; discussion 477. DOI: 10.1016/j.juro.2007.03.113
14. Hajebrahimi S, Nourizadeh D, Hamedani R, Pezeshki MZ. Validity and reliability of the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form and its correlation with urodynamic findings. Urol J. 2012;9(4):685-90. PMID: 23235974
15. McDonald J, Homewood D, West C, Fong E, Elmer S. Managing female stress urinary incontinence in a post mesh era: What to do and when to refer. Aust J Gen Pract. 2024;53(5):283-288. DOI: 10.31128/AJGP-11-23-7019
16. Liao Y, Wu Y, Zou J, Huang R, Xia W, Yuan Y, Xiao R, Wang X, Wu G, Zou X, Zhang G. Pretreatment of the urethral mucosa at the tip of the prostate: a retrospective review in preventing stress urinary incontinence after thulium laser enucleation of the prostate. Front Surg. 2024;11:1305006. DOI: 10.3389/fsurg.2024.1305006
17. Silva LA, Andriolo RB, Atallah ÁN, da Silva EM. Surgery for stress urinary incontinence due to presumed sphincter deficiency after prostate surgery. Cochrane Database Syst Rev. 2014;2014(9):CD008306. DOI: 10.1002/14651858.CD008306.pub3
18. Nackeeran S, Morgan KM, Chen H, Anger JT, Sur RL, Sheetz T. The 21st century marks a rise in TURP retreatment rates: an analysis of Veterans Health Administration data. World J Urol. 2025;43(1):701. DOI: 10.1007/s00345-025-06083-5
19. Houssin V, Olivier J, Brenier M, Pierache A, Laniado M, Mouton M, Theveniaud PE, Baumert H, Mallet R, Marquette T, Villers A, Robert G, Rizk J. Predictive factors of urinary incontinence after holmium laser enucleation of the prostate: a multicentric evaluation. World J Urol. 2021;39(1):143-148. DOI: 10.1007/s00345-020-03169-0
20. International Continence Society (ICS). Urgency urinary incontinence (sign). Bristol: ICS. Accessed March 5, 2026. URL: https://www.ics.org/glossary/sign/urgencyurinaryincontinence
21. Mohamed-Ahmed R, Taithongchai A, da Silva AS, Robinson D, Cardozo L. Treating and Managing Urinary Incontinence: Evolving and Potential Multicomponent Medical and Lifestyle Interventions. Res Rep Urol. 2023;15:193-203. DOI: 10.2147/RRU.S387205
22. Jeong J, Lee HS, Cho WJ, Jung W, You HW, Kim TH, Sung HH, Lee KS. Effect of Detrusor Overactivity on Functional Outcomes After Holmium Laser Enucleation of the Prostate in Patients With Benign Prostatic Obstruction. Urology. 2015;86(1):133-8. DOI: 10.1016/j.urology.2015.03.033
23. Schumacher S, Marghawal D, Brunken C, Herzberg J. Patient reported outcome and quality of life measured by a simple questionnaire in patients with symptomatic benign prostate hyperplasia treated by holmium laser enucleation of the prostate (HoLEP). Front Surg. 2024;11:1358701. DOI: 10.3389/fsurg.2024.1358701
24. Nam JK, Kim HW, Lee DH, Han JY, Lee JZ, Park SW. Risk Factors for Transient Urinary Incontinence after Holmium Laser Enucleation of the Prostate. World J Mens Health. 2015;33(2):88-94. DOI: 10.5534/wjmh.2015.33.2.88
25. Rassweiler J, Teber D, Kuntz R, Hofmann R. Complications of transurethral resection of the prostate (TURP)--incidence, management, and prevention. Eur Urol. 2006;50(5):969-79; discussion 980. DOI: 10.1016/j.eururo.2005.12.042
26. Kim SJ, Park SG, Pak S, Kwon O, Lee YG, Cho ST. Predictive factors for postoperative medication therapy for overactive bladder symptoms after holmium laser enucleation of prostate. Int J Urol. 2023;30(11):1036- 1043. DOI: 10.1111/iju.15260
27. Bogdanov D.A., Yusufov A.G., Guspanov R.I., Kotov S.V. Overactive bladder following surgical intervention for benign prostatic hyperplasia: treatment outcomes in routine clinical practice. Urology Herald. 2025;13(3):19-29. (In Russian). DOI: 10.21886/2308-6424-2025-13-3-19-29
28. Kamalov AA, Sorokin NI, Strigunov AA, Nesterova OY, Bondar IV. Incidence and predictors of urinary incontinence rates after thulium fiber laser enucleation of prostate performed by single surgeon. Arab J Urol. 2024;22(4):261-267. DOI: 10.1080/20905998.2024.2330737
29. Yan J, Gao L, Xu G, Zhang J. The effectiveness and safety of three surgical procedures for the treatment for benign prostatic hyperplasia: A network meta-analysis. Heliyon. 2022;8(10):e10884. DOI: 10.1016/j.heliyon.2022.e10884
30. Licari LC, Bologna E, Manfredi C, Franco A, Ditonno F, DE Nunzio C, Franco G, Cindolo L, Leonardo C, Adelstein SA, Fiori C, Cherullo EE, Olweny EO, Autorino R. Postoperative urinary incontinence following BPH surgery: insights from a comprehensive national database analysis. Minerva Urol Nephrol. 2024;76(5):618-624. DOI: 10.23736/S2724-6051.24.05802-6
31. Cornu JN, Ahyai S, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S. A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update. Eur Urol. 2015;67(6):1066-1096. DOI: 10.1016/j.eururo.2014.06.017
32. Vo LT, Armany D, Chalasani V, Bariol SV, Baskaranathan S, Hossack T, Ende D, Woo HH. Endoscopic enucleation of the prostate versus transurethral resection of the prostate for benign prostatic hyperplasia: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2025;28(4):845-858. DOI: 10.1038/s41391-025-00970-z
33. Oelke M, Baard J, Wijkstra H, de la Rosette JJ, Jonas U, Höfner K. Age and bladder outlet obstruction are independently associated with detrusor overactivity in patients with benign prostatic hyperplasia. Eur Urol. 2008;54(2):419-26. DOI: 10.1016/j.eururo.2008.02.017
34. Mamaev I.E., Sushkova Yu.V., Kotov S.V. Prognostic factors for the success of BPH/BPO surgery in patients with suprapubic tube. Urology Herald. 2024;12(3):62-69. (In Russian). DOI: 10.21886/2308-6424-2024-12-3-62-69
35. Li J, Wang D, Tian H, Yang J, Xia H, Guo W. Association between lipid accumulation products and stress urinary incontinence: a cross-sectional study from NHANES 2005 to 2018. Lipids Health Dis. 2024 Nov 4;23(1):358. DOI: 10.1186/s12944-024-02350-3
36. Yanagiuchi A, Miyake H, Tanaka K, Fujisawa M. Significance of preoperatively observed detrusor overactivity as a predictor of continence status early after robot-assisted radical prostatectomy. Asian J Androl. 2014;16(6):869-72. DOI: 10.4103/1008-682X.132784
37. Chen SF, Lee CL, Kuo HC. Change of Detrusor Contractility in Patients with and without Bladder Outlet Obstruction at Ten or More Years of follow-up. Sci Rep. 2019;9(1):18887. DOI: 10.1038/s41598-019-55386-2
38. Coman RA, Bschleipfer T, Al Hajjar N, Petrut B. Predictive Factors of Transient Urinary Incontinence Following Holmium Laser Enucleation of the Prostate (HoLEP): Single-Center Experience. Medicina (Kaunas). 2024;60(9):1460. DOI: 10.3390/medicina60091460.
39. Edwards A, Agarwal R, Bates J, Bray A, Milosevic S, Thomas-Jones E, Drinnan M, Drake M, Michell P, Pell B, Ahmed H, Joseph-Williams N, Hood K, Takwoingi Y, Harding C. Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study. Health Technol Assess. 2025;29(1):1-140. DOI: 10.3310/RGTW5711
40. Akshay A, Gheinani AH, Besic M, Braga S, Uldry AC, Heller M, Rehrauer H, Fournier CA, Burkhard FC, Monastyrskaya K. De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC Urol. 2024;24(1):33. DOI: 10.1186/s12894-024-01417-8
41. Bosch R, Abrams P, Averbeck MA, Finazzi Agró E, Gammie A, Marcelissen T, Solomon E. Do functional changes occur in the bladder due to bladder outlet obstruction? — ICI-RS 2018. Neurourol Urodyn. 2019;38 Suppl 5(Suppl 5):S56-S65. DOI: 10.1002/nau.24076
42. Lee HY, Wang CS, Juan YS. Detrusor Underactivity in Men with Bladder Outlet Obstruction. Biomedicines. 2022;10(11):2954. DOI: 10.3390/biomedicines10112954
43. Gauhar V, Castellani D, Herrmann TRW, Gökce MI, Fong KY, Gadzhiev N, Malkhasyan V, Pirola GM, Naselli A, Mahajan A, Maheshwari PN, Biligere S, Tursunkulov AN, Nasirov F, Petov V, Dellabella M, Lim EJ, Socarrás MR, Zawadzki M, Cormio L, Busetto GM, Teoh JY, Somani BK, Enikeev D, Sofer M, Gómez Sancha F. Incidence of complications and urinary incontinence following endoscopic enucleation of the prostate in men with a prostate volume of 80 ml and above: results from a multicenter, real-world experience of 2512 patients. World J Urol. 2024;42(1):180. DOI: 10.1007/s00345-024-04886-6
44. Mungovan SF, Sandhu JS, Akin O, Smart NA, Graham PL, Patel MI. Preoperative Membranous Urethral Length Measurement and Continence Recovery Following Radical Prostatectomy: A Systematic Review and Meta-analysis. Eur Urol. 2017;71(3):368-378. DOI: 10.1016/j.eururo.2016.06.023
45. Lan XD, Jiang R, Wang H, Mulati Y, Zhang K, Zhang Q, Wu J, Meng Y, Meng YS. P.I. nomogram: an exploratory imaging-derived model for predicting early urinary incontinence following ThuLEP. World J Urol. 2026;44(1):123. DOI: 10.1007/s00345-026-06205-7
46. Gu Z, Zheng Z, Zhang W, Mao S, Wang S, Geng J, Yao X. The development and assessment of a predicting nomogram for the recovery of immediate urinary continence following laparoscopic radical prostatectomy. Front Surg. 2023;9:1071093. DOI: 10.3389/fsurg.2022.1071093
47. Oka S, Kobayashi K, Matsuda K, Takai K. Significance of Membranous Urethral Length for Recovery From Postoperative Urinary Incontinence Following Holmium Laser Enucleation of the Prostate. Int Neurourol J. 2020;24(4):358-364. DOI: 10.5213/inj.2040042.021.
48. Shigemura K, Tanaka K, Yamamichi F, Chiba K, Fujisawa M. Comparison of Predictive Factors for Postoperative Incontinence of Holmium Laser Enucleation of the Prostate by the Surgeons’ Experience During Learning Curve. Int Neurourol J. 2016;20(1):59-68. DOI: 10.5213/inj.1630396.198
49. Collins GS, Moons KGM, Dhiman P, Riley RD, Beam AL, Van Calster B, Ghassemi M, Liu X, Reitsma JB, van Smeden M, Boulesteix AL, Camaradou JC, Celi LA, Denaxas S, Denniston AK, Glocker B, Golub RM, Harvey H, Heinze G, Hoffman MM, Kengne AP, Lam E, Lee N, Loder EW, Maier-Hein L, Mateen BA, McCradden MD, Oakden-Rayner L, Ordish J, Parnell R, Rose S, Singh K, Wynants L, Logullo P. TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods. BMJ. 2024;385:e078378. DOI: 10.1136/bmj-2023-078378
50. Moons KGM, Wolff RF, Riley RD, Whiting PF, Westwood M, Collins GS, Reitsma JB, Kleijnen J, Mallett S. PROBAST: A Tool to Assess Risk of Bias and Applicability of Prediction Model Studies: Explanation and Elaboration. Ann Intern Med. 2019;170(1):W1-W33. DOI: 10.7326/M18-1377
51. Li X, He F, Huang C, Zhang L, Liu Q, Song J. Development and validation of a nomogram for predicting early stress urinary incontinence following endoscopic enucleation of the prostate. World J Urol. 202;39(9):3447-3453. DOI: 10.1007/s00345-021-03592-x
52. Fong KY, Gauhar V, Herrmann TRW, Nedbal C, Enikeev D, Teoh JY, Biligere S, Yuen SKK, Castellani D, Somani BK, Juliebø-Jones P, Gan VHL, Aslim EJ, Lim EJ. Machine learning models to predict postoperative incontinence after endoscopic enucleation of the prostate for benign prostatic hyperplasia: An EAU-Endourology study. Prostate Cancer Prostatic Dis. 2026;29(1):175-180. DOI: 10.1038/s41391-025-01015-1
53. Shin H, Ko KJ, Park WJ, Han DH, Yeom I, Lee KS. Machine Learning Models for the Noninvasive Diagnosis of Bladder Outlet Obstruction and Detrusor Underactivity in Men With Lower Urinary Tract Symptoms. Int Neurourol J. 2024;28(Suppl 2):S74-81. DOI: 10.5213/inj.2448360.180
Review
For citations:
Meshcheriakova E.A., Neftulaev R.R., Nesterova O.Yu., Strigunov A.A., Nikolaev M.Yu., Yusupov K.M., Okhobotov D.A., Sorokin N.I., Kamalov A.A. Prevalence and prediction of urinary incontinence after transurethral surgery for prostatic hyperplasia: evaluation of different approaches. Urology Herald. 2026;14(2):102-111. (In Russ.) https://doi.org/10.21886/2308-6424-2026-14-2-102-111
JATS XML





































