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The landscape of erectile dysfunction: insights into diagnosis, management, and emerging interventions

https://doi.org/10.21886/2308-6424-2026-14-2-77-89

Abstract

Erectile dysfunction is aprevalent condition affecting millions of men worldwide, with significant implications for physical health, psychological well-being, and quality of life. This systematic literature review aims to provide a comprehensive overview of the current landscape of ED, focusing on its diagnosis, management, and emerging interventions. A structured search of peer-reviewed literature was conducted across multiple databases, including PubMed and Cochrane Library, using predefined inclusion and exclusion criteria. The review highlights the multifactorial nature of erectile dysfunction, emphasizing the importance of accurate diagnosis through tools such as the International Index of Erectile Function, penile Doppler ultrasound, and nocturnal penile tumescence testing. Pharmacological treatments, particularly phosphodiesterase type 5 inhibitors, remain the cornerstone of management, while nonpharmacological options like vacuum erection devices and psychotherapy play complementary roles. Emerging therapies, including stem cell therapy, platelet-rich plasma therapy, and low-intensity extracorporeal shockwave therapy, offer promising avenues for refractory cases. Despite advancements, challenges such as stigma, cost, and limited access to innovative treatments persist. This review underscores the need for a multidisciplinary approach to erectile dysfunction care and calls for further research to refine diagnostic tools, optimize treatment strategies, and enhance accessibility to cutting-edge interventions. By addressing these gaps, we can improve outcomes for men with erectile dysfunction and promote holistic sexual health.

About the Authors

S. A. Abbosov
Tashkent State Medical University; Republican Specialized Scientific and Practical Medical Centre of Urology
Uzbekistan

Shukhrat A. Abbosov — Сand.Sc.(Med) 

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



A. T. Makhmudov
Tashkent State Medical University; Republican Specialized Scientific and Practical Medical Centre of Urology
Uzbekistan

Azamjon T. Makhmudov — Dr.Sc.(Med)

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



A. K. Tulaboev
Tashkent State Medical University
Uzbekistan

Azamjon K. Tulaboev — Dr.Sc.(Econ) 

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



S. U. Aliev
Tashkent State Medical University
Uzbekistan

Sarvar U. Aliev — Сand.Sc.(Pharm)

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



A. B.   Shomarufov
Tashkent State Medical University; Republican Specialized Scientific and Practical Medical Centre of Urology
Uzbekistan

Azizbek B. Shomarufov — Сand.Sc.(Med) 

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



S. Sh. Shavakhabov
Republican Specialized Scientific and Practical Medical Centre of Urology
Uzbekistan

Shavkat Sh. Shavakhabov — Сand.Sc.(Med)

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



F. A. Akilov
Tashkent State Medical University
Uzbekistan

Farkhad A. Akilov — M.D., Dr.Sc.(Med) 

Tashkent


Competing Interests:

Farkhad A. Akilov, author of this article, are member of the Editorial Council of Urology Herald. The manuscript underwent the journal’s standard external peer‑review process by independent experts. The authors declare no other conflicts of interest



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Review

For citations:


Abbosov S.A., Makhmudov A.T., Tulaboev A.K., Aliev S.U., Shomarufov A.B., Shavakhabov S.Sh., Akilov F.A. The landscape of erectile dysfunction: insights into diagnosis, management, and emerging interventions. Urology Herald. 2026;14(2):77-89. https://doi.org/10.21886/2308-6424-2026-14-2-77-89

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ISSN 2308-6424 (Online)