Simultaneous and staged surgeries in urological patients within an Enhanced Recovery After Surgery (ERAS) pathway: safety and efficacy evaluation
https://doi.org/10.21886/2308-6424-2025-13-5-49-59
Abstract
Introduction. Combined surgical pathology poses a dilemma between simultaneous and staged approaches. Simultaneous surgeries, performed during a single anesthetic session, reduce hospitalization time, lower anesthetic burden, however, increased operative volume and duration may elevate the risk of complications. The staged approach reduces the immediate burden on the patient but requires multiple hospitalizations, prolongs overall treatment and recovery time.
Objective. To compare clinical outcomes, length of hospitalization, postoperative complications and effectiveness of simultaneous versus staged urological surgeries within a structured enhanced recovery after surgery (ERAS) protocol.
Materials & methods. A prospective single-center randomized study evaluating the safety of simultaneous and staged urological surgeries included 78 patients with combined urological and surgical pathologies, randomized into two groups. Compliance with the ERAS protocol above 80% was a criterion for inclusion in both groups. Group 1 (n = 53) underwent simultaneous surgeries, where multiple procedures were performed during a single operative session. Group 2 (n = 25) received staged treatment, with surgical interventions separated in time. Perioperative parameters, complication rates according to the Clavien-Dindo classification, length of hospitalization, patient-reported outcomes including postoperative pain assessed by the visual analog scale (VAS), requirement for opioid analgesics, intraoperative blood loss, total duration of urinary drainage, and cumulative surgical access size were evaluated.
Results. Simultaneous surgeries demonstrated a significant reduction in overall hospitalization time (p < 0.01) and total operative time compared with staged interventions. No statistically significant differences in postoperative complication rates were observed between groups (p = 0.94).
Conclusion. Both simultaneous and staged urological surgeries are safe approaches for patients with combined pathology. Simultaneous interventions offer advantages including reduced hospitalization time without increasing the risk of postoperative complications.
About the Authors
A. R. TukhievRussian Federation
Arthur R. Tukhiev
Irkutsk
V. A. Vorobev
Russian Federation
Vladimir A. Vorobev — Dr.Sc.(Med), Full Prof.
Irkutsk, Ufa
D. V. Tukhieva
Russian Federation
Darya V. Tukhieva
Irkutsk
K. M. Su-Yanz
Russian Federation
Kirill M. Su-Yanz
Irkutsk
References
1. Fedorov A.V., Kriger A.G., Kolygin A.V., Kochatkov A.V. To the terminology of simultaneous operations. Surgery. Pirogov Journal. 2011;(7):72 76. (In Russian). eLIBRARY ID: 18212943; EDN: PIOKGB
2. Zhang X, Zhao X, Zheng J, Hao C. Bilateral simultaneous percutaneous nephrolithotomy versus staged approach for bilateral upper urinary tract calculi: A meta-analysis. Asian J Surg. 2023;46(1):553-555. DOI: 10.1016/j.asjsur.2022.06.167
3. Koutserimpas C, Rob E, Servien E, Lustig S, Batailler C. Similar complications and outcomes with simultaneous versus staged bilateral total hip arthroplasty with the direct anterior approach: A comparative study. SICOT J. 2024;10:31. DOI: 10.1051/sicotj/2024028
4. Yaqub S, Margonis GA, Søreide K. Staged or Simultaneous Surgery for Colon or Rectal Cancer with Synchronous Liver Metastases: Implications for Study Design and Clinical Endpoints. Cancers (Basel). 2023;15(7):2177. DOI: 10.3390/cancers15072177
5. Liu L, Liu H, Zhang H, Song J, Zhang L. Bilateral total knee arthroplasty: Simultaneous or staged? A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(22):e15931. DOI: 10.1097/MD.0000000000015931
6. Hussain N, Chien T, Hussain F, Bookwala A, Simunovic N, Shetty V, Bhandari M. Simultaneous versus staged bilateral total knee arthroplasty: a meta-analysis evaluating mortality, peri-operative complications and infection rates. HSS J. 2013;9(1):50-59. DOI: 10.1007/s11420-012-9315-7
7. Alshaikh AM, Alshaeri NM, Jamal R, Almaghthawi OF, Al Eid MM, Alfageeh ZS, Alturkistani AM, Ali AMB. Mortality Following Simultaneous Versus Staged Bilateral Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. Cureus. 2023;15(12):e50823. DOI: 10.7759/cureus.50823
8. Wu Y, Mao A, Wang H, Fang G, Zhou J, He X, Cai S, Wang L. Association of Simultaneous vs Delayed Resection of Liver Metastasis With Complications and Survival Among Adults With Colorectal Cancer. JAMA Netw Open. 2022;5(9):e2231956. DOI: 10.1001/jamanetworkopen.2022.31956
9. Chen J, Li Q, Wang C, Zhu H, Shi Y, Zhao G. Simultaneous vs. staged resection for synchronous colorectal liver metastases: a metaanalysis. Int J Colorectal Dis. 2011;26(2):191-199. DOI: 10.1007/s00384-010-1018-2
10. Rasmussen A, Levine MA, Mandurah MM, Sener A, Luke PP. Staged vs. simultaneous bilateral nephrectomy and kidney transplantation in patients with autosomal dominant polycystic kidney disease: Outcomes and costs. Can Urol Assoc J. 2022;16(12):424-429. DOI: 10.5489/cuaj.7816
11. Golbrah V.A., Maskin S.S., Matiukhin V.V., Klimovich I.N., Arutiunian A.G. Modern approaches to simultaneous operations (indications, execution algorithms, complications). Journal of Volgograd State Medical University. 2021;18(2):28-36. (In Russian). DOI: 10.19163/1994-9480-2021-2(78)-28-36
12. Milazzo M, Todeschini L, Caimano M, Mattia A, Cristin L, Martinino A, Bianco G, Spoletini G, Giovinazzo F. Surgical Resection in Colorectal Liver Metastasis: An Umbrella Review. Cancers (Basel). 2024;16(10):1849. DOI: 10.3390/cancers16101849
13. Lorenzon L, Caccialanza R, Casalone V, Santoro G, Delrio P, Izzo F, Tonello M, Mele MC, Pozzo C, Pedrazzoli P, Pietrabissa A, Fenu P, Mellano A, Fenocchio E, Avallone A, Bergamo F, Nardi MT, Persiani R, Biondi A, Tirelli F, Agnes A, Ferraris R, Quarà V, Milanesio M, Ribero D, Rinaldi M, D’Elia P, Rho M, Cenzi C, D’Ugo D. The impact of preoperative nutritional screening, ERAS protocol, and mini-invasive surgery in surgical oncology: A multi-institutional SEM analysis of patients with digestive cancer. Front Nutr. 2023;10:1041153. DOI: 10.3389/fnut.2023.1041153
14. Vorobev N.V., Krasheninnikov A.A., Ashyrova F.S., Golubev P.V., Samsonov Yu.V., Kaprin A.D. Simultaneous surgical treatment of patients with primary multiple synchronous kidney and prostate cancer. Research and Practical Medicine Journal. 2019;6(2):120-129. (In Russian). DOI: 10.17709/2409-2231-2019-6-2-12
15. Timerbulatov M.V., Shornina A.S., Ibragimov D.R. Combination of hernia and abdominoplasty: main aspects and modern view on simultaneous operations. Medical Bulletin of Bashkortostan. 2022;17(1):65-70. (In Russian). eLIBRARY ID: 49533362; EDN: KXXYHI
16. Popov S.V., Guseynov R.G., Orlov I.N., Topuzov T.M., Skryabin O.N., Perepelitsa V.V., Katunin A.S., Yasheva S.Yu., Zaycev A.S. Simultaneous procedures in urological practice. Urologiia. 2022;(3):5-14. (In Russian). DOI: 10.18565/urology.2022.3.5-14
17. Khodjimatov GM, Egitov AA. Simultaneous Laparoscopy Operations on Organs of the Brotherhood (Literature Review). Am J Pediatr Med Health Sci. 2024;2(1):133-137.
Review
For citations:
Tukhiev A.R., Vorobev V.A., Tukhieva D.V., Su-Yanz K.M. Simultaneous and staged surgeries in urological patients within an Enhanced Recovery After Surgery (ERAS) pathway: safety and efficacy evaluation. Urology Herald. 2025;13(5):49-59. (In Russ.) https://doi.org/10.21886/2308-6424-2025-13-5-49-59





































