Preview

Urology Herald

Advanced search

Ejaculatory-projective techniques in the surgical treatment of benign prostatic hyperplasia

https://doi.org/10.21886/2308-6424-2025-13-4-79-88

Abstract

Introduction. Retrograde ejaculation (RE) has many well-described causes, ranging from pharmacological disturbances to interference with innervation mechanisms during surgical treatment of benign prostatic hyperplasia (BPH).

Objective. To explore the anatomical and physiological aspects of retrograde ejaculation (RE) and to critically evaluate published evidence regarding the preservation of antegrade ejaculation following various ejaculatory-sparing procedures, drawing on the latest medical literature.

Materials & Methods. A comprehensive literature search was performed across PubMed, MEDLINE, and Scopus databases for the period 1966–2024. Differential searches employed the keywords «benign prostatic hyperplasia», «retrograde ejaculation», «ejaculatory-protective techniques», «transurethral enucleation», «assessment of ejaculatory disorders», and «physiology of ejaculation». In total, 1126 sources were screened, with 51 articles included for review.

Results. The main perspectives on the anatomo-physiological basis of RE were identified, alongside the subjective methods used to assess ejaculatory disorders. Additionally, current ejaculatory-protective techniques and alternative surgical approaches for the treatment of BPH were highlighted. Advances in high-tech medical care for BPH have already provided patients undergoing transurethral procedures with the possibility of fathering children. Consequently, patient expectations today extend beyond mere symptom relief to include improved psycho-emotional wellbeing and enhanced quality of life in social aspects.

Conclusion. Implementation of ejaculatory-sparing surgical techniques markedly improves the psychosocial outcomes and overall quality of life for patients treated for BPH. Continued investigation into the mechanisms of RE, as well as the refinement of surgical methods, is warranted to further mitigate this complication and optimize patient-centred care.

About the Authors

M. P. Korchagin
Russian University of Medicine
Russian Federation

Mikhail P. Korchagin

Moscow



R. Yu. Andreev
Botkin City Clinical Hospital
Russian Federation

Roman Yu. Andreev – Cand.Sc.(Med).

Moscow



K. B. Kolontarev
Russian University of Medicine; Botkin City Clinical Hospital
Russian Federation

Konstantin B. Kolontarev – Dr.Sc.(Med).

Moscow



D. Yu. Pushkar
Russian University of Medicine; Botkin City Clinical Hospital
Russian Federation

Dmitry Yu. Pushkar – Dr.Sc.(Med), Full Prof., Acad. of the RAS

Moscow



References

1. Bostwick D. The pathology of benign prostatic hyperplasia. In: Kirby P, McConnell J, Fitzpatrick J, eds. The Textbook of Benign Prostatic Hyperplasia. London: Isis Medical Media; 2002.

2. Gravas S., Gacci M, Gratzke C., Herrmann T.R.W., Karavitakis M., Kyriazis I., Malde S., Mamoulakis C., Rieken M., Sakalis V.I., Schouten N., Speakman M.J., Tikkinen K.A.O., Cornu J.N. Summary Paper on the 2023 European Association of Urology Guidelines on the Management of Non-neurogenic Male Lower Urinary Tract Symptoms. Eur Urol. 2023;84(2):207-222. DOI: 10.1016/j.eururo.2023.04.008

3. Cornu J.N., Ahyai S., Bachmann A., de la Rosette J., Gilling P., Gratzke C., McVary K., Novara G., Woo H., Madersbacher S. A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update. Eur Urol. 2015;67(6):1066-1096. DOI: 10.1016/j.eururo.2014.06.017

4. van Kerrebroeck P., Chapple C., Drogendijk T., Klaver M., Sokol R., Speakman M., Traudtner K., Drake M.J.; NEPTUNE Study Group. Combination therapy with solifenacin and tamsulosin oral controlled absorption system in a single tablet for lower urinary tract symptoms in men: efficacy and safety results from the randomised controlled NEPTUNE trial. Eur Urol. 2013;64(6):1003-1012. DOI: 10.1016/j.eururo.2013.07.034

5. Revenig L., Leung A., Hsiao W. Ejaculatory physiology and pathophysiology: assessment and treatment in male infertility. Transl Androl Urol. 2014;3(1):41-49. DOI: 10.3978/j.issn.2223-4683.2014.02.02

6. Lipshultz L.I., Howards S.S., Niederberger C.S., eds. Infertility in the Male. Cambridge University Press; 2009.

7. Gerstenberg T.C., Levin R.J., Wagner G. Erection and ejaculation in man. Assessment of the electromyographic activity of the bulbocavernosus and ischiocavernosus muscles. Br J Urol. 1990;65(4):395-402. DOI: 10.1111/j.1464-410x.1990.tb14764.x

8. Yang C.C., Bradley W.E. Innervation of the human anterior urethra by the dorsal nerve of the penis. Muscle Nerve. 1998;21(4):514-518. DOI: 10.1002/(sici)1097-4598(199804)21:4<514::aid-mus10>3.0.co;2-x

9. Ishigami T., Yoshioka K., Karicheti V., Marson L. A role for peripheral 5-HT2 receptors in serotonin-induced facilitation of the expulsion phase of ejaculation in male rats. J Sex Med. 2013;10(11):2688-2702. DOI: 10.1111/jsm.12306

10. Huyghe E., Cuzin B., Grellet L., Faix A., Almont T., Burte C. Recommandations pour le traitement de l’éjaculation prématurée [Recommendations for the treatment of premature ejaculation]. Prog Urol. 2023;33(5):237- 246. (In French). DOI: 10.1016/j.purol.2023.02.003

11. Burton T.D., Liday C. The comparison of combination SSRI and PDE-5 inhibitor therapy to SSRI monotherapy in men with premature ejaculation. Ann Pharmacother. 2011;45(7-8):1000-1004. DOI: 10.1345/aph.1Q008

12. Waldinger M.D., Schweitzer D.H., Olivier B. On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions. J Sex Med. 2005;2(1):121- 131. DOI: 10.1111/j.1743-6109.2005.20112.x

13. Gessa G.L., Tagliamonte A. Role of brain monoamines in male sexual behavior. Life Sci. 1974;14(3):425-436. DOI: 10.1016/0024-3205(74)90357-9

14. Clément P., Bernabé J., Kia H.K., Alexandre L., Giuliano F. D2-like receptors mediate the expulsion phase of ejaculation elicited by 8-hydroxy-2-(di-N-propylamino) tetralin in rats. J Pharmacol Exp Ther. 2006;316(2):830-834. DOI: 10.1124/jpet.105.092411

15. Peeters M., Giuliano F. Central neurophysiology and dopaminergic control of ejaculation. Neurosci Biobehav Rev. 2008;32(3):438-453. DOI: 10.1016/j.neubiorev.2007.07.013

16. Kalischcr O. Die Urogenitalmuskulatur des Dammes mit besonderer Berücksichtigung des Hamblasenverschlusses. Berlin, Karger; 1900.

17. Gräning W. Beitrag zur vergleichenden Ana¬ tomie der Muskulatur von Harnblase und Harnröhre. Z Anat EntwGesch. 1936;106:226-250.

18. Dorschner W., Stolzenburg J.U. A new theory of micturition and urinary continence based on histomorphological studies. 5. The musculus ejaculatorius: a newly described structure responsible for seminal emission and ejaculation. Urol Int. 1994;53(1):34-37. DOI: 10.1159/000282628

19. Parnham A., Serefoglu E.C. Retrograde ejaculation, painful ejaculation and hematospermia. Transl Androl Urol. 2016;5(4):592-601. DOI: 10.21037/tau.2016.06.05

20. Reich O., Gratzke C., Bachmann A., Seitz M., Schlenker B., Hermanek P., Lack N., Stief C.G.; Urology Section of the Bavarian Working Group for Quality Assurance. Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. J Urol. 2008;180(1):246-249. DOI: 10.1016/j.juro.2008.03.058

21. Rassweiler J., Teber D., Kuntz R., Hofmann R. Complications of transurethral resection of the prostate (TURP)--incidence, management, and prevention. Eur Urol. 2006;50(5):969-979; discussion 980. DOI: 10.1016/j.eururo.2005.12.042

22. Rosen R.C., Catania J.A., Althof S.E., Pollack L.M., O'Leary M., Seftel A.D., Coon D.W. Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction. Urology. 2007;69(5):805-809. DOI: 10.1016/j.urology.2007.02.036

23. Rosen R., Altwein J., Boyle P., Kirby R.S., Lukacs B., Meuleman E., O'Leary M.P., Puppo P., Robertson C., Giuliano F. Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7). Eur Urol. 2003;44(6):637-649. DOI: 10.1016/j.eururo.2003.08.015

24. Donovan J.L., Abrams P., Peters T.J., Kay H.E., Reynard J., Chapple C., De La Rosette J.J., Kondo A. The ICS-'BPH' Study: the psychometric validity and reliability of the ICSmale questionnaire. Br J Urol. 1996;77(4):554-562. DOI: 10.1046/j.1464-410x.1996.93013.x

25. O'Leary M.P., Fowler F.J., Lenderking W.R., Barber B., Sagnier P.P., Guess H.A., Barry M.J. A brief male sexual function inventory for urology. Urology. 1995;46(5):697-706. DOI: 10.1016/S0090-4295(99)80304-5

26. Malde S., Umbach R., Wheeler J.R., Lytvyn L., Cornu J.N., Gacci M., Gratzke C., Herrmann T.R.W., Mamoulakis C., Rieken M., Speakman M.J., Gravas S., Drake M.J., Guyatt G.H., Tikkinen K.A.O. A Systematic Review of Patients' Values, Preferences, and Expectations for the Diagnosis and Treatment of Male Lower Urinary Tract Symptoms. Eur Urol. 2021;79(6):796-809. DOI: 10.1016/j.eururo.2020.12.019

27. Gil-Vernet J.M. Jr, Alvarez-Vijande R., Gil-Vernet A., Gil-Vernet J.M. Ejaculation in men: a dynamic endorectal ultrasonographical study. Br J Urol. 1994;73(4):442-448. DOI: 10.1111/j.1464-410x.1994.tb07612.x

28. Alloussi S.H., Lang C., Eichel R., Alloussi S. Ejaculation-preserving transurethral resection of prostate and bladder neck: short- and long-term results of a new innovative resection technique. J Endourol. 2014;28(1):84-89. DOI: 10.1089/end.2013.0093

29. Sun F., Yao H., Bao X., Wang X., Wang D., Zhang D., Zhou Z., Wu J. The Efficacy and Safety of HoLEP for Benign Prostatic Hyperplasia With Large Volume: A Systematic Review and Meta-Analysis. Am J Mens Health. 2022;16(4):15579883221113203. DOI: 10.1177/15579883221113203

30. Ronzoni G., De Vecchis M. Preservation of anterograde ejaculation after transurethral resection of both the prostate and bladder neck. Br J Urol. 1998;81(6):830-833. DOI: 10.1046/j.1464-410x.1998.00658.x

31. Talab S.S., Santiago-Lastra Y.A., Bachmann A., Choi B.B., Muir G.H., Woo H.H., Tabatabaei S. V403 the impact of ejaculation-preserving photo-selective vaporization of the prostate (EP-PVP) on lower urinary tract symptoms and ejaculatory function: results of a multicenter study. Journal of Urology. 2013;189(4S):e164. DOI: 10.1016/j.juro.2013.02.1792

32. Miyauchi T., Yusu H., Kanzaki M. V3–06 ejaculation-spar- ing photoselective vaporization of the prostate: evaluation of the ejaculatory function and the lower urinary tract symptoms. Journal of Urology. 2016;195:e468. DOI: 10.1016/j.juro.2016.02.1526

33. Carmignani L., Bozzini G., Macchi A., Maruccia S., Picozzi S., Casellato S. Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia. Asian J Androl. 2015;17(5):802-806. DOI: 10.4103/1008-682X.139255

34. Trama F., Lauro G.D., Illiano E., Iacono F., Romis L., Mordente S., Nugnes M.R., Lai S., Crocetto F., Barone B., Calace F.P., Romeo G., Costantini E. Ejaculation Sparing Thulium Laser Enucleation of the Prostate: An Observational Prospective Study. J Clin Med. 2022;11(21):6365. DOI: 10.3390/jcm11216365

35. Bozzini G., Berti L., Maltagliati M., Besana U., Calori A., Müller A., Sighinolfi M.C., Micali S., Pastore A.L., Ledezma R., Broggini P., Rocco B., Buizza C. Ejaculation-sparing thulium laser enucleation of the prostate (ES-ThuLEP): outcomes on a large cohort. World J Urol. 2021;39(6):2029-2035. DOI: 10.1007/s00345-020-03442-2

36. Xu C., Xu Z., Lin C., Feng S., Sun M., Chen J., Zheng Y. Holmium Laser Enucleation of the Prostate: Modified Two-Lobe Technique versus Traditional Three-Lobe Technique-A Randomized Study. Biomed Res Int. 2019;2019:3875418. DOI: 10.1155/2019/3875418

37. Guldibi F., Altunhan A., Aydın A., Sonmez M.G., Çakır Ö.O., Balasar M., Guven S., Ahmed K. What is the effect of laser anatomical endoscopic enucleation of the prostate on the ejaculatory functions? A systematic review. World J Urol. 2023;41(12):3493-3501. DOI: 10.1007/s00345-023-04660-0

38. Manfredi C., García-Gómez B., Arcaniolo D., García-Rojo E., Crocerossa F., Autorino R., Gratzke C., De Sio M., Romero-Otero J. Impact of Surgery for Benign Prostatic Hyperplasia on Sexual Function: A Systematic Review and Meta-analysis of Erectile Function and Ejaculatory Function. Eur Urol Focus. 2022;8(6):1711-1732. DOI: 10.1016/j.euf.2022.06.007

39. Lebdai S., Ben Boujema M., Benard A., Barry Delongchamps N., Benchikh A, Bruyere F., Della Negra E., Descazeaud A., Doizi S., Fourmarier M., Mallet R., Misrai V., Pelegrin T., Rouscoff Y., Ruffion A., Villers A., Saillour F., Robert G. Standardized technique for ejaculation preservation during prostatic endoscopic ablative surgery. World J Urol. 2023;41(11):3041-3049. DOI: 10.1007/s00345-023-04592-9

40. Cornu J.N., Zantek P., Burtt G., Martin C., Martin A., Springate C., Chughtai B. Minimally Invasive Treatments for Benign Prostatic Obstruction: A Systematic Review and Network Meta-analysis. Eur Urol. 2023;83(6):534-547. DOI: 10.1016/j.eururo.2023.02.028

41. McVary K.T., Gange S.N., Gittelman M.C., Goldberg K.A., Patel K., Shore N.D., Levin R.M., Rousseau M., Beahrs J.R., Kaminetsky J., Cowan B.E., Cantrill C.H., Mynderse L.A., Ulchaker J.C., Larson T.R., Dixon C.M., Roehrborn C.G. Minimally Invasive Prostate Convective Water Vapor Energy Ablation: A Multicenter, Randomized, Controlled Study for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia. J Urol. 2016;195(5):1529-1538. DOI: 10.1016/j.juro.2015.10.181

42. McVary K.T., Gange S.N., Gittelman M.C., Goldberg K.A., Patel K., Shore N.D., Levin R.M., Rousseau M., Beahrs J.R., Kaminetsky J., Cowan B.E., Cantrill C.H., Mynderse L.A., Ulchaker J.C., Larson T.R., Dixon C.M., Roehrborn C.G. Erectile and Ejaculatory Function Preserved With Convective Water Vapor Energy Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Randomized Controlled Study. J Sex Med. 2016;13(6):924-933. DOI: 10.1016/j.jsxm.2016.03.372

43. McVary K.T., Rogers T., Roehrborn C.G. Rezūm Water Vapor Thermal Therapy for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: 4-Year Results From Randomized Controlled Study. Urology. 2019;126:171-179. DOI: 10.1016/j.urology.2018.12.041

44. Roehrborn C.G., Rukstalis D.B., Barkin J., Gange S.N., Shore N.D., Giddens J.L., Bolton D.M., Cowan B.E., Cantwell A.L., McVary K.T., Te A.E., Gholami S.S., Moseley W.G., Chin P.T., Dowling W.T., Freedman S.J., Incze P.F., Coffield K.S., Borges F.D., Rashid P. Three year results of the prostatic urethral L.I.F.T. study. Can J Urol. 2015;22(3):7772-7782. PMID: 26068624

45. Roehrborn C.G., Barkin J., Gange S.N., Shore N.D., Giddens J.L., Bolton D.M., Cowan B.E., Cantwell A.L., McVary K.T., Te A.E., Gholami S.S., Moseley W.G., Chin P.T., Dowling W.T., Freedman S.J., Incze P.F., Coffield K.S., Herron S., Rashid P., Rukstalis D.B. Five year results of the prospective randomized controlled prostatic urethral L.I.F.T. study. Can J Urol. 2017;24(3):8802-8813. PMID: 28646935

46. Beurrier S., Peyromaure M., Belas O., Barry Delongchamps N. La pose d'implants intra-prostatiques UroLift(®) est-elle une alternative chez les patients ayant une hyperplasie bénigne de la prostate ? Résultats initiaux et facteurs prédictifs d'échec [Are the UroLift(®) implants an alternative for the treatment of benign prostatic hyperplasia? Short-term results and predictive factors of failure]. Prog Urol. 2015;25(9):523-529. (In French). DOI: 10.1016/j.purol.2015.03.005

47. Plante M., Gilling P., Barber N., Bidair M., Anderson P., Sutton M., Aho T, Kramolowsky E., Thomas A., Cowan B., Kaufman R.P. Jr, Trainer A., Arther A., Badlani G., Desai M., Doumanian L., Te A.E., DeGuenther M., Roehrborn C. Symptom relief and anejaculation after aquablation or transurethral resection of the prostate: subgroup analysis from a blinded randomized trial. BJU Int. 2019;123(4):651-660. DOI: 10.1111/bju.14426

48. Balakrishnan D., Jones P., Somani B.K. iTIND: the second-generation temporary implantable nitinol device for minimally invasive treatment of benign prostatic hyperplasia. Ther Adv Urol. 2020;12:1756287220934355. DOI: 10.1177/1756287220934355

49. Chughtai B., Elterman D., Shore N., Gittleman M., Motola J., Pike S., Hermann C., Terrens W., Kohan A., Gonzalez R.R., Katz A., Schiff J., Goldfischer E., Grunberger I., Tu L.M., Alshak M.N., Kaminetzky J. The iTind Temporarily Implanted Nitinol Device for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Multicenter, Randomized, Controlled Trial. Urology. 2021;153:270-276. DOI: 10.1016/j.urology.2020.12.022

50. DeMeritt J.S., Elmasri F.F., Esposito M.P., Rosenberg G.S. Relief of benign prostatic hyperplasia-related bladder outlet obstruction after transarterial polyvinyl alcohol prostate embolization. J Vasc Interv Radiol. 2000;11(6):767-770. DOI: 10.1016/s1051-0443(07)61638-8

51. Malling B., Røder M.A., Brasso K., Forman J., Taudorf M., Lönn L. Prostate artery embolisation for benign prostatic hyperplasia: a systematic review and meta-analysis. Eur Radiol. 2019;29(1):287-298. DOI: 10.1007/s00330-018-5564-2


Review

For citations:


Korchagin M.P., Andreev R.Yu., Kolontarev K.B., Pushkar D.Yu. Ejaculatory-projective techniques in the surgical treatment of benign prostatic hyperplasia. Urology Herald. 2025;13(4):79-88. (In Russ.) https://doi.org/10.21886/2308-6424-2025-13-4-79-88

Views: 255


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2308-6424 (Online)