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Kidney cancer in a 14-year-old child: a rare clinical case description

https://doi.org/10.21886/2308-6424-2024-12-6-59-66

Abstract

   Kidney tumours are among the most common solid malignant pathologies in children, accounting for 6 % of all childhood malignancies. About 89 % of these tumors are nephroblastomas (Wilms' tumors). Renal cell carcinoma in children is extremely rare, representing less than 1 % of all renal tumor pathologies in childhood and adolescence. Given the rarity of this pathology in children and the small size of neoplasms in the renal parenchyma, differential diagnosis between renal cancer and cystic renal lesions can be challenging. This clinical case describes a successful treatment case of a 14-year-old patient with a detected renal parenchymal mass, subsequently diagnosed as renal cell carcinoma.

About the Authors

S. A. Kuznetsov
Rostov State Medical University; Rostov Regional Children's Clinical Hospital
Russian Federation

Sergey A. Kuznetsov

Rostov-on-Don


Competing Interests:

The authors declare no conflict of interest



V. V. Sizonov
Rostov State Medical University; Rostov Regional Children's Clinical Hospital
Russian Federation

Vladimir V. Sizonov, Dr.Sci.(Med.); Full Prof.

Rostov-on-Don


Competing Interests:

The authors declare no conflict of interest



I. I. Belousov
Rostov State Medical University
Russian Federation

Igor I. Belousov, Dr.Sc.(Med), Assoc.Prof.(Docent)

Rostov-on-Don


Competing Interests:

The authors declare no conflict of interest



A. S. Podrezova
Rostov State Medical University; Rostov Regional Children's Clinical Hospital
Russian Federation

Anastasia S. Podrezova

Rostov-on-Don


Competing Interests:

The authors declare no conflict of interest



References

1. Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11(1):1310. DOI: 10.1038/s41467-020-15155-6

2. Brok J, Treger TD, Gooskens SL, van den Heuvel-Eibrink MM, Pritchard-Jones K. Biology and treatment of renal tumours in childhood. Eur J Cancer. 2016;68:179-195. DOI: 10.1016/j.ejca.2016.09.005

3. Cajaiba MM, Dyer LM, Geller JI, Jennings LJ, George D, Kirschmann D, Rohan SM, Cost NG, Khanna G, Mullen EA, Dome JS, Fernandez CV, Perlman EJ. The classification of pediatric and young adult renal cell carcinomas registered on the children’s oncology group (COG) protocol AREN03B2 after focused genetic testing. Cancer. 2018;124(16):3381-3389. DOI: 10.1002/cncr.31578

4. Ginsburg KB, Johnson K, Moldovan T, Peabody H, Qi J, Dunn RL, Rogers C, Weizer A, Kaul S, Johnson A, Traver M, Lane BR; Michigan Urological Surgery Improvement Collaborative. A Statewide Quality Improvement Collaborative’s Adherence to the 2017 American Urological Association Guidelines Regarding Initial Evaluation of Patients With Clinical T1 Renal Masses. Urology. 2021;158:117-124. DOI: 10.1016/j.urology.2021.08.036

5. Schieda N, Vakili M, Dilauro M, Hodgdon T, Flood TA, Shabana WM. Solid Renal Cell Carcinoma Measuring Water Attenuation (-10 to 20 HU) on Unenhanced CT. AJR Am J Roentgenol. 2015;205(6):1215-1221. Erratum in: AJR Am J Roentgenol. 2016;206(4):901. DOI: 10.2214/AJR.15.14554.

6. Gobara A, Yoshizako T, Yoshida R, Katsube T, Ishikura Y, Kamimura T, Kaji Y. Radiological Features of T1a Renal Cell Carcinoma on Axial Unenhanced Computed Tomography. Cureus. 2023;15(3):e36881. DOI: 10.7759/cureus.36881

7. Jonisch AI, Rubinowitz AN, Mutalik PG, Israel GM. Can high-attenuation renal cysts be differentiated from renal cell carcinoma at unenhanced CT? Radiology. 2007;243(2):445-450. DOI: 10.1148/radiol.2432060559

8. Ljungberg B, Albiges L, Abu-Ghanem Y, Bedke J, Capitanio U, Dabestani S, Fernández-Pello S, Giles RH, Hofmann F, Hora M, Klatte T, Kuusk T, Lam TB, Marconi L, Powles T, Tahbaz R, Volpe A, Bex A. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update. Eur Urol. 2022;82(4):399-410. DOI: 10.1016/j.eururo.2022.03.006

9. Burnand K, Roberts A, Bouty A, Nightingale M, Campbell M, Heloury Y. Laparoscopic nephrectomy for Wilms’ tumor: Can we expand on the current SIOP criteria? J Pediatr Urol. 2018;14(3):253.e1-253.e8. DOI: 10.1016/j.jpurol.2018.01.005

10. Kim SP, Murad MH, Thompson RH, Boorjian SA, Weight CJ, Han LC, Erwin PJ, Costello BA, Chow GK, Leibovich BC. Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors : A Systematic Review and Meta-Analysis. J Urol. 2012:S0022-5347(12)05254-8. Epub ahead of print. DOI: 10.1016/j.juro.2012.10.026

11. Indolfi P, Terenziani M, Casale F, Carli M, Bisogno G, Schiavetti A, Mancini A, Rondelli R, Pession A, Jenkner A, Pierani P, Tamaro P, De Bernardi B, Ferrari A, Santoro N, Giuliano M, Cecchetto G, Piva L, Surico G, Di Tullio MT. Renal cell carcinoma in children: a clinicopathologic study. J Clin Oncol. 2003;21(3):530-535. DOI: 10.1200/JCO.2003.02.072

12. Indolfi P, Bisogno G, Cecchetto G, Spreafico F, De Salvo GL, Collini P, Jenkner A, Inserra A, Schiavetti A, di Martino M, Casale F. Local lymph node involvement in pediatric renal cell carcinoma: a report from the Italian TREP project. Pediatr Blood Cancer. 2008;51(4):475-478. DOI: 10.1002/pbc.21652

13. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med. 1996;335(12):865-875. DOI: 10.1056/NEJM199609193351207

14. Geller JI, Cost NG, Chi YY, Tornwall B, Cajaiba M, Perlman EJ, Kim Y, Mullen EA, Glick RD, Khanna G, Daw NC, Ehrlich P, Fernandez CV, Dome JS; Children’s Oncology Group (COG) Renal Tumor Committee. A prospective study of pediatric and adolescent renal cell carcinoma: A report from the Children’s Oncology Group AREN0321 study. Cancer. 2020;126(23):5156-5164. DOI: 10.1002/cncr.33173

15. Abdellah A, Selma K, Elamin M, Asmae T, Lamia R, Abderrahmane M, Sanaa el M, Hanan E, Tayeb K, Noureddine B. Renal cell carcinoma in children: case report and literature review. Pan Afr Med J. 2015;20:84. DOI: 10.11604/pamj.2015.20.84.5791


Review

For citations:


Kuznetsov S.A., Sizonov V.V., Belousov I.I., Podrezova A.S. Kidney cancer in a 14-year-old child: a rare clinical case description. Urology Herald. 2024;12(6):59-66. (In Russ.) https://doi.org/10.21886/2308-6424-2024-12-6-59-66

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ISSN 2308-6424 (Online)