ASSESMENT TUBULOINTERSTITIAL CHANGES IN THE RENAL PARENCHYMA IN THE SURGICAL TREATMENT OF NEPHROLITHIASIS
https://doi.org/10.21886/2308-6424-2014-0-1-3-10
Abstract
The aim of this study was to evaluate changes in tubulointerstitial renal parenchyma in patients with nephrolithiasis at various stages of surgical treatment using mediators nephrofibrosis and angiogenesis and the results of intraoperative biopsy of kidney. Results of surgical treatment of 65 patients with nephrolithiasis were studied. In serum and urine of patients content determined molecular mediators that characterize nephrosclerosis. It is shown that the most informative markers of tubulointerstitial fibrosis are IL12, VEGF in serum and excreted in the urine β2 MG, MCP 1 and NO. High level markers nephrosclerosis, conserved in the postoperative period in patients with bilateral nephrolithiasison the background existing tubulointerstitial damage indicates irreversibility nephrosclerosis and further progression of chronic kidney disease.
About the Authors
G. N. Maslyakova
Research Institute of Fundamental and Clinical Uronephrology Saratov State Medical University named after V.I.Razumovsky, Saratov
Russian Federation
Russian Federation
A. N. Rossolovsky
Research Institute of Fundamental and Clinical Uronephrology Saratov State Medical University named after V.I.Razumovsky, Saratov
Russian Federation
Russian Federation
A. M. Napsheva
Research Institute of Fundamental and Clinical Uronephrology Saratov State Medical University named after V.I.Razumovsky, Saratov
Russian Federation
Russian Federation
N. B. Zakharova
Head of Scientific Investigative Laboratory Saratov State Medical University named after V.I.Razumovsky
Russian Federation
Russian Federation
References
1. Дзеранов, Н.К. Мочекаменная болезнь. Клинические рекомендации / Н.К. Дзеранов, Н.А. Лопаткин. – М., 2007. – С.29.
2. Klahr, S. Obstructive nephropathy / S. Klahr // Kidney Int. – 1998, Vol. 54. – P.286-300.
3. Земченков, А.Ю. К/ДОКИ обращается к истокам хронической почечной недостаточности (о новом разделе Рекомендаций K/DOQI по диагностике, классификации и оценке тяжести хронических заболеваний почек) / А.Ю. Земченков, Н.А. Томилина // Нефрология и диализ. – 2004. – №3. – С.204-220.
4. Fine, L.G. Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics / L.G. Fine , J.T. Norman // Kidney Int. – 2008. – Vol.16 – P.98-106.
5. Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies and chronic interstitial nephritides / A. Boble, G.A. Muller, W. Webmann et al. // Kidney Int. – 1996. – Vol.54. – P.2-9.
6. Wada, T. Chemokines:new target molecules in renal diseases / T. Wada // Clin Exp Neph. – 2000. – Vol.4. – Р.273- 280.
7. Nitrite and nitrate determination in plasma: A critical evaluation / H. Моsbage, B. Kok, R. Huzenga et al. // Clin Chem. – 1995. – Vol.41. – P.892-896.
8. О клиническом значении тубуло- интерстициальных изменений при хроническом гломерулонефрите / В.В. Ставская, С.И. Рябов, И.К. Клемина // Клин. мед. – 1987. – №10. – С.125-129.
Review
For citations:
Maslyakova G.N., Rossolovsky A.N., Napsheva A.M., Zakharova N.B. ASSESMENT TUBULOINTERSTITIAL CHANGES IN THE RENAL PARENCHYMA IN THE SURGICAL TREATMENT OF NEPHROLITHIASIS. Urology Herald. 2014;(1):3-10. (In Russ.) https://doi.org/10.21886/2308-6424-2014-0-1-3-10
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