Preview

Вестник урологии

Расширенный поиск

Патоспермия и актуальные методы её лечения

https://doi.org/10.21886/2308-6424-2025-13-4-89-96

Аннотация

Обзор литературы посвящён актуальной медико-социальной проблеме – мужскому бесплодию. В статье приведены данные о факторах, способствующих нарушению сперматогенеза и развитию патоспермии. Показана роль окислительного стресса в патогенезе патоспермии и мужского бесплодия. Представлены методы лечения патоспермии. Подчёркнута роль антиоксидантной терапии в лечении патоспермии. Приведены данные о высокой эффективности мелатонина и положительном его влиянии на показатели спермограммы.

Об авторах

А. И. Неймарк
Алтайский государственный медицинский университет
Россия

Александр Израилевич Неймарк – д-р мед. наук; профессор

Барнаул



А. В. Яковлев
Алтайский государственный медицинский университет
Россия

Андрей Владимирович Яковлев – канд. мед. наук

Барнаул



И. В. Каблова
Алтайский государственный медицинский университет
Россия

Ирина Викторовна Каблова – канд. мед. наук

Барнаул



З. Ш. Манасова
Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России
Россия

Зарипат Шахбановна Манасова – канд. мед. наук

Москва



Н. С. Андриуца
Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России
Россия

Наталья Сергеевна Андриуца – канд. мед. наук

Москва



А. В. Ершов
Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России; Научно-исследовательский институт общей реаниматологии им. В.А. Неговского
Россия

Антон Валерьевич Ершов – д-р мед. наук

Москва



Список литературы

1. Литвинова Н.А., Лесников А.И., Толочко Т.А., Шмелев А.А. Эндогенные и экзогенные факторы, влияющие на мужскую фертильность. Фундаментальная и клиническая медицина. 2021;6(2):124-135.

2. Rotimi D.E., Singh S.K. Implications of lifestyle factors on male reproductive health. JBRA Assist Reprod. 2024;28(2):320-330. DOI: 10.5935/1518-0557.20240007

3. Mardomi F.D., Deljavan-Nikouei F.H., Babayev M.Sh. Main trends of the genetic factor of male infertility. Austrian Journal of Technical and Natural Sciences. 2020;9-10:6-10. DOI: 10.29013/AJT-20-9.10-6-10

4. Wang K., Gao Y., Wang C., Liang M., Liao Y., Hu K. Role of Oxidative Stress in Varicocele. Front Genet. 2022;13:850114. DOI: 10.3389/fgene.2022.850114

5. Kalmatov R.K., Mirzokulov S.S., Mirzakulov D.S., Matazov B.A., Eshbaev A.A., Makambaev A.B. Influence of urogenital infections on the development of male infertility in the Jalal-Abad Region of the Kyrgyz republic. Bulletin of Osh State University. 2023;(2):41-49. (In Russian). DOI: 10.52754/16948610_2023_2_5

6. Wagner A.O., Turk A., Kunej T. Towards a Multi-Omics of Male Infertility. World J Mens Health. 2023;41(2):272-288. DOI: 10.5534/wjmh.220186

7. Biggs S.N., Kennedy J., Lewis S.L., Hearps S., O'Bryan M.K., McLachlan R., von Saldern S., Chambers G., Halliday J. Lifestyle and environmental risk factors for unexplained male infertility: study protocol for Australian Male Infertility Exposure (AMIE), a case-control study. Reprod Health. 2023;20(1):32. DOI: 10.1186/s12978-023-01578-z

8. Chereshnev V.A., Pichugova S.V., Beikin Y.B., Chereshneva M.V., Iukhta A.I., Stroev Y.I., Churilov L.P. Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation. Pathophysiology. 2021;28(4):471-488. DOI: 10.3390/pathophysiology28040030

9. Alekseeva D.B., Alexina A.A. Morphology of spermatozoa and their qualitative assessment. Mezhdunarodny`j studencheskij nauchny`j vestnik. 2021;(2):166. (In Russian). eLIBRARY ID: 45692025; EDN: NEVVBO

10. Solovova O.A., Chernykh V.B. Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men. Andrologiya i genital’naya khirurgiya = Andrology and Genital Surgery. 2019;20(2):16-28. (In Russian). eLIBRARY ID: 37658853; EDN: EZXKYT

11. Sataeva T.P., Koval'chuk A.V., Kutja S.A. The sperm life cycle. Physiology and pathology. Krymskij zhurnal jeksperimental'noj i klinicheskoj mediciny. 2018;8(1):113-122. (In Russian). eLIBRARY ID: 35310851; EDN: XUEHXF

12. Ivanova O.S., Ismailov T.K., Turlybekova G.K. Vliyanie vozrastnogo faktora muzhchin na pokazateli spermogrammy. Tendentsii razvitiya nauki i obrazovaniya. 2023;(104-11):98-101. (In Russian). DOI: 10.18411/trnio-12-2023-614

13. Olefir Yu.V., Vinogradov I.V., Rodionov M.A., Zhyvulko A.R., Popov D.M., Monakov D.M. The Sixth Edition of the WHO laboratory manual for the examination and processing of human semen: is everything new a well-forgotten old? Urology Herald. 2023;11(1):171-176. (In Russian). DOI: 10.21886/2308-6424-2023-11-1-171-176

14. Xia T.J., Xie F.Y., Fan Q.C., Yin S., Ma J.Y. Analysis of factors affecting testicular spermatogenesis capacity by using the tissue transcriptome data from GTEx. Reprod Toxicol. 2023;117:108359. DOI: 10.1016/j.reprotox.2023.108359

15. Bhattacharya K., Sengupta P., Dutta S. Role of melatonin in male reproduction. Asian Pacific Journal of Reproduction. 2019;8(5):211-219. DOI: 10.4103/2305-0500.268142

16. Rivero M.J., Kulkarni N., Thirumavalavan N., Ramasamy R. Evaluation and management of male genital tract infections in the setting of male infertility: an updated review. Curr Opin Urol. 2023;33(3):180-186. DOI: 10.1097/MOU.0000000000001081

17. Xu Y., Chen W., Wu X., Zhao K., Liu C., Zhang H. The Role of Cells and Cytokines in Male Infertility Induced by Orchitis. World J Mens Health. 2024;42(4):681-693. DOI: 10.5534/wjmh.230270

18. Rowley J., Vander Hoorn S., Korenromp E., Low N., Unemo M., Abu-Raddad L.J., Chico R.M., Smolak A., Newman L., Gottlieb S., Thwin S.S., Broutet N., Taylor M.M. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97(8):548-562P. DOI: 10.2471/BLT.18.228486

19. Khalafalla K., El Ansari W., Sengupta P., Majzoub A., Elbardisi H., Canguven O., El-Ansari K., Arafa M. Are sexually transmitted infections associated with male infertility? A systematic review and in-depth evaluation of the evidence and mechanisms of action of 11 pathogens. Arab J Urol. 2023;21(4):216-232. DOI: 10.1080/2090598X.2023.2218566

20. Goulart A.C.X., Farnezi H.C.M., França J.P.B.M., Santos A.D., Ramos M.G., Penna M.L.F. HIV, HPV and Chlamydia trachomatis: impacts on male fertility. JBRA Assist Reprod. 2020;24(4):492-497. DOI: 10.5935/1518-0557.20200020

21. Farsimadan M., Motamedifar M. Bacterial infection of the male reproductive system causing infertility. J Reprod Immunol. 2020;142:103183. DOI: 10.1016/j.jri.2020.103183

22. Dutta S., Sengupta P. SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology. Reprod Sci. 2021;28(1):23-26. DOI: 10.1007/s43032-020-00261-z

23. Sengupta P., Roychoudhury S., Nath M., Dutta S. Oxidative Stress and Idiopathic Male Infertility. Adv Exp Med Biol. 2022;1358:181-204. DOI: 10.1007/978-3-030-89340-8_9

24. Das S., Doss C.G.P, Fletcher J., Kannangai R., Abraham P., Ramanathan G. The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review. J Med Virol. 2023;95(4):e28697. DOI: 10.1002/jmv.28697

25. Garolla A., Graziani A., Grande G., Ortolani C., Ferlin A. HPV-relateddiseases in male patients: an underestimated conundrum. J Endocrinol Invest. 2024;47(2):261-274. DOI: 10.1007/s40618-023-02192-3

26. Sucato A., Buttà M., Bosco L., Di Gregorio L., Perino A., Capra G. Human Papillomavirus and Male Infertility: What Do We Know? Int J Mol Sci. 2023;24(24):17562. DOI: 10.3390/ijms242417562

27. Wu H., Wang F., Tang D., Han D. Mumps Orchitis: Clinical Aspects and Mechanisms. Front Immunol. 2021;12:582946. DOI: 10.3389/fimmu.2021.582946

28. Guo X., Xu J., Zhao Y., Wang J., Fu T., Richard M.L., Sokol H., Wang M., Li Y., Liu Y., Wang H., Wang C., Wang X., He H., Wang Y., Ma B., Peng S. Melatonin alleviates heat stress-induced spermatogenesis dysfunction in male dairy goats by regulating arachidonic acid metabolism mediated by remodeling the gut microbiota. Microbiome. 2024;12(1):233. DOI: 10.1186/s40168-024-01942-6

29. Zhang M., Wen T., Wang D. The association between COVID-19 and infertility: Mendelian randomization analysis. Medicine (Baltimore). 2024;103(10):e37346. DOI: 10.1097/MD.0000000000037346

30. Chen L., Huang X., Yi Z., Deng Q., Jiang N., Feng C., Zhou Q., Sun B., Chen W., Guo R. Ultrasound Imaging Findings of Acute Testicular Infection in Patients With Coronavirus Disease 2019: A Single-Center-Based Study in Wuhan, China. J Ultrasound Med. 2021;40(9):1787-1794. DOI: 10.1002/jum.15558

31. Araújo A.L.M., Almeida V.L.L., Costa T.M.L., Mendonça A.C.G., Penna M.L.F., Santos A.D., Ramos M.G. Evaluation of the effects of COVID-19 on semen parameters and male infertility. JBRA Assist Reprod. 2024;28(1):90-95. DOI: 10.5935/1518-0557.20230067

32. Koç E., Keseroğlu B.B. Does COVID-19 Worsen the Semen Parameters? Early Results of a Tertiary Healthcare Center. Urol Int. 2021;105(9-10):743-748. DOI: 10.1159/000517276

33. Li H., Xiao X., Zhang J., Zafar M.I., Wu C., Long Y., Lu W., Pan F., Meng T., Zhao K., Zhou L., Shen S., Liu L., Liu Q., Xiong C. Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine. 2020;28:100604. DOI: 10.1016/j.eclinm.2020.100604

34. Wang Z., Xu X. scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020;9(4):920. DOI: 10.3390/cells9040920

35. Kul'chenko N.G. The main types of antioxidant therapy of pathospermia. Vestnik medicinskogo instituta "REAVIZ": reabilitacija, vrach i zdorov'e. 2018;1(31):41-48. (In Russian). eLIBRARY ID: 32823966; EDN: YWLXMB

36. Chen J., Chen J., Fang Y., Shen Q., Zhao K., Liu C., Zhang H. Microbiology and immune mechanisms associated with male infertility. Front Immunol. 2023;14:1139450. DOI: 10.3389/fimmu.2023.1139450

37. Melnyk O., Kovalenko I., Vorobets M., Onufrovych O., Borzhievsky A., Fafula R. Infectious factors detectin in azoospermia on infertile men. German International Journal of Modern Science. 2021;14:29-31. DOI: 10.24412/2701-8369-2021-14-29-31

38. Mazzilli R., Petrucci S., Zamponi V., Golisano B., Pecora G., Mancini C., Salerno G., Alesi L., De Santis I., Libi F., Rossi C., Borro M., Raffa S., Visco V., Defeudis G., Piane M., Faggiano A. Seminological, Hormonal and Ultrasonographic Features of Male Factor Infertility Due to Genetic Causes: Results from a Large Monocentric Retrospective Study. J Clin Med. 2024;13(15):4399. DOI: 10.3390/jcm13154399

39. Kuroda S., Usui K., Sanjo H., Takeshima T., Kawahara T., Uemura H., Yumura Y. Genetic disorders and male infertility. Reprod Med Biol. 2020;19(4):314-322. DOI: 10.1002/rmb2.12336

40. Witherspoon L., Dergham A,. Flannigan R. Y-microdeletions: a review of the genetic basis for this common cause of male infertility. Transl Androl Urol. 2021;10(3):1383-1390. DOI: 10.21037/tau-19-599

41. Joseph S., Mahale S.D. Male Infertility Knowledgebase: Decoding the genetic and disease landscape. Database (Oxford). 2021;baab049. DOI: 10.1093/database/baab049

42. Panchenko I.A., Panchenko R.I., Naumov V.K. The effect of surgical treatment of varicocele on the pathospermia and the level of fragmentation of sperm DNA. Andrologija i genital'naja hirurgija. 2024;25(2):104-109. (In Russian). eLIBRARY ID: 68483123; EDN: FQGERE

43. Agrucz R.V., Yakovecz E.A. Evaluation of the effectiveness of surgical treatment of varicocele in men with infertility. Nauchnoe obozrenie. Medicinskie nauki. 2020;2:35-39. (In Russian). DOI: 10.17513/srms.1102

44. Persad E., O'Loughlin C.A., Kaur S., Wagner G., Matyas N., Hassler-Di Fratta M.R., Nussbaumer-Streit B. Surgical or radiological treatment for varicoceles in subfertile men. Cochrane Database Syst Rev. 2021;4(4):CD000479. DOI: 10.1002/14651858.CD000479.pub6

45. Wang L.H., Zheng L., Jiang H., Jiang T. Research advances in inflammation and oxidative stress in varicocele-induced male infertility: a narrative review. Asian J Androl. 2025;27(2):177-184. DOI: 10.4103/aja202488

46. Su J.S., Farber N.J., Vij S.C. Pathophysiology and treatment options of varicocele: An overview. Andrologia. 2021;53(1):e13576. DOI: 10.1111/and.13576

47. Lisovskaya T.V., Dubrovina O.S., Treshchilov I.M., Senturina L.B., Sevostyanova O.Y., Mayasina E.N., Buev Y.E., Salimov D.F. Thyroid disorders and pathospermia in the ART clinic patients. Gynecol Endocrinol. 2021;37(sup1):4-7. DOI: 10.1080/09513590.2021.2006439

48. Huang R., Chen J., Guo B., Jiang C., Sun W. Diabetes-induced male infertility: potential mechanisms and treatment options. Mol Med. 2024;30(1):11. DOI: 10.1186/s10020-023-00771-x

49. Łakoma K., Kukharuk O., Śliż D. The Influence of Metabolic Factors and Diet on Fertility. Nutrients. 2023;15(5):1180. DOI: 10.3390/nu15051180

50. Lyons H.E., Gyawali P., Mathews N., Castleton P., Mutuku S.M., McPherson N.O. The influence of lifestyle and biological factors on semen variability. J Assist Reprod Genet. 2024;41(4):1097-1109. DOI: 10.1007/s10815-024-03030-y

51. Efremov E.A., Kasatonova E.V. Current and promising methods of treatment of idiopathic male infertility. Andrologiya i genital`naya xirurgiya. 2022;23(3):48-53. (In Russian). eLIBRARY ID: 49391348; EDN: AXMIRE

52. Kaltsas A. Oxidative Stress and Male Infertility: The Protective Role of Antioxidants. Medicina (Kaunas). 2023;59(10):1769. DOI: 10.3390/medicina59101769

53. Rashki Ghaleno L., Alizadeh A., Drevet J.R., Shahverdi A., Valojerdi M.R. Oxidation of Sperm DNA and Male Infertility. Antioxidants (Basel). 2021;10(1):97. DOI: 10.3390/antiox10010097

54. Dimitriadis F., Borgmann H., Struck J.P., Salem J., Kuru T.H. Antioxidant Supplementation on Male Fertility-A Systematic Review. Antioxidants (Basel). 2023;12(4):83. DOI: 10.3390/antiox12040836

55. Abouelgreed T.A., Amer M.A., Mamdouh H., El-Sherbiny A.F., Aboelwafa H., Fahmy S.F., Omar O.A., Abdelshakour M., Elesawy M., Sonbol M., Maawad A.N., Elsayed O.K. The influence of oral antioxidants on men with infertility: a systemic review. Arch Ital Urol Androl. 2024;96(2):12323. DOI: 10.4081/aiua.2024.12323

56. Kallinikas G., Tsoporis J.N., Haronis G., Zarkadas A., Bozios D., Konstantinopoulos V., Kozyrakis D., Mitiliniou D., Rodinos E., Filios A., Filios P., Vlassopoulos G. The role of oral antioxidants in the improvement of sperm parameters in infertile men. World J Urol. 2024;42(1):71. DOI: 10.1007/s00345-023-04766-5

57. Soleimani Mehranjani M., Azizi M., Sadeghzadeh F. The effect of melatonin on testis histological changes and spermatogenesis indexes in mice following treatment with dexamethasone. Drug Chem Toxicol. 2022;45(3):1140-1149. DOI: 10.1080/01480545.2020.1809672

58. Frungieri M.B., Calandra R.S., Rossi S.P. Local Actions of Melatonin in Somatic Cells of the Testis. Int J Mol Sci. 2017;18(6):1170. DOI: 10.3390/ijms18061170

59. Wang Y., Zhao T.T., Zhao H.Y., Wang H. Melatonin protects methotrexateinduced testicular injury in rats. Eur Rev Med Pharmacol Sci. 2018;22(21):7517-7525. DOI: 10.26355/eurrev_201811_16293

60. Yang M., Guan S., Tao J., Zhu K., Lv D., Wang J, Li G., Gao Y., Wu H., Liu J, Cao L., Fu Y., Ji P., Lian Z., Zhang L., Liu G. Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells†. Biol Reprod. 2021;104(6):1322-1336. DOI: 10.1093/biolre/ioab046

61. Lu X.L., Liu J.J., Li J.T., Yang Q.A., Zhang J.M. Melatonin therapy adds extra benefit to varicecelectomy in terms of sperm parameters, hormonal profile and total antioxidant capacity: A placebo-controlled, doubleblind trial. Andrologia. 2018;50(6):e13033. DOI: 10.1111/and.13033

62. Zhao F., Whiting S., Lambourne S., Aitken R.J., Sun Y.P. Melatonin alleviates heat stress-induced oxidative stress and apoptosis in human spermatozoa. Free Radic Biol Med. 2021;164:410-416. DOI: 10.1016/j.freeradbiomed.2021.01.014


Рецензия

Для цитирования:


Неймарк А.И., Яковлев А.В., Каблова И.В., Манасова З.Ш., Андриуца Н.С., Ершов А.В. Патоспермия и актуальные методы её лечения. Вестник урологии. 2025;13(4):89-96. https://doi.org/10.21886/2308-6424-2025-13-4-89-96

For citation:


Neymark A.I., Yakovlev A.V., Kablova I.V., Manasova Z.Sh., Andriutsa N.S., Yershov A.V. Semen parameter disorders and methods of correction. Urology Herald. 2025;13(4):89-96. (In Russ.) https://doi.org/10.21886/2308-6424-2025-13-4-89-96

Просмотров: 11


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2308-6424 (Online)