Surgical technique for preventing lymphatic complications during robot-assisted radical prostatectomy
https://doi.org/10.21886/2308-6424-2024-12-3-88-96
Abstract
Introduction. Radical prostatectomy (RP) stands the gold standard method of treatment for localised prostate cancer. Pelvic lymph node dissection (PLND) is a common surgical procedure that can be used for both diagnostic and therapeutic purposes. Lymphocele is the most common complication after robot-assisted radical prostatectomy (RARP) and PLND.
Objective. To develop a surgical technique aimed at reducing the incidence of lymphocele in patients who underwent RARP with TL and to evaluate its efficacy and safety.
Materials & methods. The study included 49 patients who underwent RARP and PLND. The patients were divided into 2 groups: group 1 — patients with free peritoneal flap fixed to the pubic bone after RARP and PLND (n = 25) and group 2 — control group «without peritoneal flap fixation» (n = 24). The average follow-up period was 3 months.
Results. No significant differences in clinical parameters were observed between the groups in perioperative period. In postoperative period lymphocele was diagnosed in 5 (10.2%) patients: group 1 — 1 (4%) patients, group 2 — 4 (16.7%). There were no significant differences in lymphocele volume between the groups. In group 1 lymphocele had no clinical manifestation. Symptomatic lymphocele was diagnosed in 1 patient (4.2%) from the control group.
Conclusion. The surgical technique of a free peritoneal flap fixation to the pubic bone combined with PLND after RARP may reduce the incidence of lymphocele if compared to the standard technique.
About the Authors
K. S. SkrupskiyRussian Federation
Konstantin S. Skrupskiy
Moscow
K. B. Kolontarev
Russian Federation
Konstantin B. Kolontarev — Dr.Sc.(Med), Full Prof.
Moscow
A. V. Govorov
Russian Federation
Aleksandr V. Govorov — Dr.Sc.(Med)
Moscow
V. V. Dyakov
Russian Federation
Vladimir V. Dyakov — Cand.Sc.(Med)
Moscow
A. L. Sarukhanian
Russian Federation
Arman L. Sarukhanian
Moscow
I. O. Gritskov
Russian Federation
Igor O. Gritskov
Moscow
D. Yu. Pushkar
Russian Federation
Dmitry Yu. Pushkar — Dr.Sc.(Med), Full Prof., Acad. of the RAS
Moscow
References
1. Ramazanov K.K., Kolontarev K.B., Ter-Ovanesov M.D., Govorov A.V., Vasilyev A.O., Kazakov A.S., Pushkar D.Yu. Comparative analysis of 10-year functional outcomes of robot-assisted radical prostatectomy and radical retropubic prostatectomy. Experience of the Urology Clinic of the A.I. Evdokimov Moscow State University of Medicine and Dentistry. Cancer Urology. 2023;19(2):56-65. (In Russian). DOI: 10.17650/1726-9776-2023-19-2-56-65
2. Ramazanov K.K., Kolontarev K.B., Gens G.P., Govorov A.V., Vasilyev A.O., Sadcheko А.V., Alaverdyan A.I., Stroganov R.V., Skrupskiy K.S., Kim Yu.A., Shiryaev A.А., Pushkar D.Yu. Long-term oncological and functional results of robot-assisted radical prostatectomy. Cancer Urology. 2021;17(3):121-128. (In Russian). DOI: 10.17650/1726-9776-2021-17-3-121-128
3. Ryabov M.A., Kotov S.V. Comparative assessment of the learning curve of retropubic, laparoscopic, perineal, and robot-assisted radical prostatectomy. Urology Herald. 2022;10(2):63-71. (In Russian). DOI: 10.21886/2308-6424-2022-10-2-63-71
4. Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol. 2021;79(2):243-262. DOI: 10.1016/j.eururo.2020.09.042
5. Cacciamani GE, Maas M, Nassiri N, Ortega D, Gill K, Dell'Oglio P, Thalmann GN, Heidenreich A, Eastham JA, Evans CP, Karnes RJ, De Castro Abreu AL, Briganti A, Artibani W, Gill I, Montorsi F. Impact of Pelvic Lymph Node Dissection and Its Extent on Perioperative Morbidity in Patients Undergoing Radical Prostatectomy for Prostate Cancer: A Comprehensive Systematic Review and Meta-analysis. Eur Urol Oncol. 2021;4(2):134-149. DOI: 10.1016/j.euo.2021.02.001
6. Fujimoto N, Shiota M, Tomisaki I, Minato A, Yahara K. Reconsideration on Clinical Benefit of Pelvic Lymph Node Dissection during Radical Prostatectomy for Clinically Localized Prostate Cancer. Urol Int. 2019;103(2):125-136. DOI: 10.1159/000497280
7. Fossati N, Willemse PM, Van den Broeck T, van den Bergh RCN, Yuan CY, Briers E, Bellmunt J, Bolla M, Cornford P, De Santis M, MacPepple E, Henry AM, Mason MD, Matveev VB, van der Poel HG, van der Kwast TH, Rouvière O, Schoots IG, Wiegel T, Lam TB, Mottet N, Joniau S. The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review. Eur Urol. 2017;72(1):84-109. DOI: 10.1016/j.eururo.2016.12.003
8. Sarkar RR, Bryant AK, Parsons JK, Ryan ST, Karim Kader A, Kane CJ, McKay RR, Sandhu A, Murphy JD, Rose BS. Association between Radical Prostatectomy and Survival in Men with Clinically Node-positive Prostate Cancer. Eur Urol Oncol. 2019;2(5):584-588. DOI: 10.1016/j.euo.2018.09.015
9. Ploussard G, Briganti A, de la Taille A, Haese A, Heidenreich A, Menon M, Sulser T, Tewari AK, Eastham JA. Pelvic lymph node dissection during robot-assisted radical prostatectomy: efficacy, limitations, and complications-a systematic review of the literature. Eur Urol. 2014;65(1):7-16. DOI: 10.1016/j.eururo.2013.03.057
10. Kolontarev K.B., Pushkar D.Yu. Robot-assisted urology: national handbook. Moscow: GEOTAR-Media; 2023. (In Russiaan). ISBN: 978-5-9704-7511-9
11. Briganti A, Chun FK, Salonia A, Suardi N, Gallina A, Da Pozzo LF, Roscigno M, Zanni G, Valiquette L, Rigatti P, Montorsi F, Karakiewicz PI. Complications and other surgical outcomes associated with extended pelvic lymphadenectomy in men with localized prostate cancer. Eur Urol. 2006;50(5):1006-1013. DOI: 10.1016/j.eururo.2006.08.015
12. Grande P, Di Pierro GB, Mordasini L, Ferrari M, Würnschimmel C, Danuser H, Mattei A. Prospective Randomized Trial Comparing Titanium Clips to Bipolar Coagulation in Sealing Lymphatic Vessels During Pelvic Lymph Node Dissection at the Time of Robot-assisted Radical Prostatectomy. Eur Urol. 2017;71(2):155-158. DOI: 10.1016/j.eururo.2016.08.006
13. Epstein JI, Zelefsky MJ, Sjoberg DD, Nelson JB, Egevad L, Magi-Galluzzi C, Vickers AJ, Parwani AV, Reuter VE, Fine SW, Eastham JA, Wiklund P, Han M, Reddy CA, Ciezki JP, Nyberg T, Klein EA. A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. Eur Urol. 2016;69(3):428-435. DOI: 10.1016/j.eururo.2015.06.046
14. Mottrie A, Van Migem P, De Naeyer G, Schatteman P, Carpentier P, Fonteyne E. Robot-assisted laparoscopic radical prostatectomy: oncologic and functional results of 184 cases. Eur Urol. 2007;52(3):746-750. DOI: 10.1016/j.eururo.2007.02.029
15. Lestingi JFP, Guglielmetti GB, Trinh QD, Coelho RF, Pontes J Jr, Bastos DA, Cordeiro MD, Sarkis AS, Faraj SF, Mitre AI, Srougi M, Nahas WC. Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial. Eur Urol. 2021;79(5):595-604. DOI: 10.1016/j.eururo.2020.11.040
16. Touijer KA, Sjoberg DD, Benfante N, Laudone VP, Ehdaie B, Eastham JA, Scardino PT, Vickers A. Limited versus Extended Pelvic Lymph Node Dissection for Prostate Cancer: A Randomized Clinical Trial. Eur Urol Oncol. 2021;4(4):532-539. DOI: 10.1016/j.euo.2021.03.006
17. Stolzenburg JU, Wasserscheid J, Rabenalt R, Do M, Schwalenberg T, McNeill A, Constantinides C, Kallidonis P, Ganzer R, Liatsikos E. Reduction in incidence of lymphocele following extraperitoneal radical prostatectomy and pelvic lymph node dissection by bilateral peritoneal fenestration. World J Urol. 2008;26(6):581-586. DOI: 10.1007/s00345-008-0327-3
18. Lebeis C, Canes D, Sorcini A, Moinzadeh A. Novel Technique Prevents Lymphoceles After Transperitoneal Robotic-assisted Pelvic Lymph Node Dissection: Peritoneal Flap Interposition. Urology. 2015;85(6):1505-1509. DOI: 10.1016/j.urology.2015.02.034
19. Lee M, Lee Z, Eun DD. Utilization of a Peritoneal Interposition Flap to Prevent Symptomatic Lymphoceles After Robotic Radical Prostatectomy and Bilateral Pelvic Lymph Node Dissection. J Endourol. 2020;34(8):821-827. DOI: 10.1089/end.2020.0073
20. Bründl J, Lenart S, Stojanoski G, Gilfrich C, Rosenhammer B, Stolzlechner M, Ponholzer A, Dreissig C, Weikert S, Burger M, May M. Peritoneal Flap in Robot-Assisted Radical Prostatectomy. Dtsch Arztebl Int. 2020;117(14):243-250. DOI: 10.3238/arztebl.2020.0243
21. Stolzenburg JU, Arthanareeswaran VKA, Dietel A, Franz T, Liatsikos E, Kyriazis I, Ganzer R, Yaney K, Do HM. Four-point Peritoneal Flap Fixation in Preventing Lymphocele Formation Following Radical Prostatectomy. Eur Urol Oncol. 2018;1(5):443-448. DOI: 10.1016/j.euo.2018.03.004
22. Dal Moro F, Zattoni F. P.L.E.A.T.-Preventing Lymphocele Ensuring Absorption Transperitoneally: A Robotic Technique. Urology. 2017;110:244-247. DOI: 10.1016/j.urology.2017.05.031
23. Boğa MS, Sönmez MG, Karamık K, Yılmaz K, Savaş M, Ateş M. The effect of peritoneal re-approximation on lymphocele formation in transperitoneal robot-assisted radical prostatectomy and extended pelvic lymphadenectomy. Turk J Urol. 2020;46(6):460-467. DOI: 10.5152/tud.2020.20255
24. Student V Jr, Tudos Z, Studentova Z, Cesak O, Studentova H, Repa V, Purova D, Student V. Effect of Peritoneal Fixation (PerFix) on Lymphocele Formation in Robot-assisted Radical Prostatectomy with Pelvic Lymphadenectomy: Results of a Randomized Prospective Trial. Eur Urol. 2023;83(2):154-162. Erratum in: Eur Urol. 2024;85(3):e95. DOI: 10.1016/j.eururo.2022.07.027
25. Gloger S, Ubrig B, Boy A, Leyh-Bannurah SR, Siemer S, Arndt M, Stolzenburg JU, Franz T, Oelke M, Witt JH. Bilateral Peritoneal Flaps Reduce Incidence and Complications of Lymphoceles after Robotic Radical Prostatectomy with Pelvic Lymph Node Dissection-Results of the Prospective Randomized Multicenter Trial ProLy. J Urol. 2022;208(2):333-340. DOI: 10.1097/JU.0000000000002693
26. Kotov S.V., Prostomolotov A.O., Nemenov A.A. Risk factors of developing lymphogenic complications after radical prostatectomy with lymph node dissection. Urologiia. 2021;(3):114-121. (In Russian). DOI: 10.18565/urology.2021.3.114-121
Review
For citations:
Skrupskiy K.S., Kolontarev K.B., Govorov A.V., Dyakov V.V., Sarukhanian A.L., Gritskov I.O., Pushkar D.Yu. Surgical technique for preventing lymphatic complications during robot-assisted radical prostatectomy. Urology Herald. 2024;12(3):88-96. (In Russ.) https://doi.org/10.21886/2308-6424-2024-12-3-88-96