Efficacy of combined phytotherapy (NefroBest® and UroBest®) in female patients with urolithiasis and preoperative drainage of upper urinary tract before ureteroscopy

Introduction. In most cases, double-J stent placement is the initial method of drainage in patients with urolithiasis. Until ureteroscopic intervention, most patients report «stent-related symptoms» that reduce the quality of life.

Objective. To improve the results of treatment in female patients with urinary stone disease (USD) and preoperative drainage of the upper urinary tract using double-J stent by assessing the effect of the NefroBest® and UroBest® complexes on the prevention of the development of «stent-related symptoms» and inflammatory processes.

Materials & methods. The study group included 90 female patients with USD, who were performed ureteroscopic interventions with preoperative stent placement from March to September 2023 in the Yudin City Clinical Hospital. Patients were divided into two groups: the main group 1 (n = 30) — patients who received phytotherapy with NefroBest® (30 days) and UroBest® (7 days) complexes after placement of an internal ureteral stent; the control group 2 (n = 60) — patients who did not receive specific therapy postoperatively.

Results. According to the USSQ, in group 1 the median score due to urinary symptoms was 22 points, and in group 2 — 28 points (p = 0.001), when assessing symptoms associated with pain — 12 and 18 points (p < 0.001), general health — 17 points both and work performance — 9 and 11 points, respectively. Among patients in group 1, stonefree rate was observed in 90.0%, and among patients in group 2 — in 93.3%. In group 1, antibacterial therapy in the postoperative period was in 37.0% of patients, and in group 2 – among 53.0%.

Conclusion. The co-use of the NefroBest® and UroBest® complexes in female patients with USD and preoperative drainage of the upper urinary tract using double-J stent can reduce the severity of symptoms associated with urination and pain, and postoperatively resulted in a lower incidence of infectious-inflammatory complications.

1. Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y. Epidemiology of stone disease across the world. World J Urol. 2017;35(9):1301-1320. DOI: 10.1007/s00345-017-2008-6

2. Tundo G, Khaleel S, Pais VM Jr. Gender Equivalence in the Prevalence of Nephrolithiasis among Adults Younger than 50 Years in the United States. J Urol. 2018;200(6):1273-1277. DOI: 10.1016/j.juro.2018.07.048

3. Beara-Lasic L, Goldfarb DS. Nephrolithiasis in women: how different from men? Curr Opin Nephrol Hypertens. 2020;29(2):201-206. DOI: 10.1097/MNH.0000000000000577

4. Kittanamongkolchai W, Vaughan LE, Enders FT, Dhondup T, Mehta RA, Krambeck AE, McCollough CH, Vrtiska TJ, Lieske JC, Rule AD. The Changing Incidence and Presentation of Urinary Stones Over 3 Decades. Mayo Clin Proc. 2018;93(3):291-299. DOI: 10.1016/j.mayocp.2017.11.018

5. Ho CH, Liu SP, Wang CW, Liao PW. Complete intraureteral stent placement reduces stent-related symptoms: Systemic review and meta-analysis. J Formos Med Assoc. 2022;121(11):2308-2316. DOI: 10.1016/j.jfma.2022.06.014

6. Dorfman M, Chan SB, Hayek K, Hill C. Pyuria and Urine Cultures in Patients with Acute Renal Colic. J Emerg Med. 2016;51(4):358-364. DOI: 10.1016/j.jemermed.2015.10.043

7. Boeykens M, Keller EX, Bosio A, Wiseman OJ, Contreras P, Ventimiglia E, Talso M, Pietropaolo A, Tailly T, De Coninck V. Impact of Ureteral Stent Material on Stent-related Symptoms: A Systematic Review of the Literature. Eur Urol Open Sci. 2022;45:108-117. DOI: 10.1016/j.euros.2022.09.005

8. Martov A.G., Ergakov D.V., Novikov A.B., Mantsaev A.B. Stent-related symptoms: prevention and treatment. Moscow urologist, 2020;(3):13–15 (In Russian).

9. Pecoraro A, Peretti D, Tian Z, Aimar R, Niculescu G, Alleva G, Piana A, Granato S, Sica M, Amparore D, Checcucci E, Manfredi M, Karakiewicz P, Fiori C, Porpiglia F. Treatment of Ureteral Stent-Related Symptoms. Urol Int. 2023;107(3):288-303. DOI: 10.1159/000518387

10. Kolpacinidi F.G., Sergeev V.P., Kyzlasov P.S., Volokitin E.V., Abuev G.G., Mustafaev A.T., Korobov A.A. Experience of using «NefroBest-N» for rehabilitation of patients undergoing radical laparoscopic cystectomy. Urologiia. 2023;(4):62-68. (In Russian). DOI: 10.18565/urology.2023.4.62-68

11. Prosyannikov M.Yu., Sivkov A.V., Konstantinova O.V., Voytko D.A., Anokhin N.V., Golovanov S.A., Apolikhin O.I., Kaprin A.D. Adherence of patients to metaphylaxis of urolithiasis. Experimental and Clinical Urology. 2022;15(2)54-65. (In Russian). DOI: 10.29188/2222-8543-2022-15-2-54-65

12. Kotov S.V., Nemenov A.A., Perov R.A., Sokolov N.M. Genderrelated differences and its effects on ureteroscopy success. Urology Herald. 2023;11(3):35-43. (In Russian). DOI: 10.21886/2308-6424-2023-11-3-35-43