MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY
https://doi.org/10.21886/2308-6424-2013-0-2-43-51
Abstract
There is presentation of paths of the pathogenesis of renal scaring from vesico-ureteral reflux at this article. Author demonstrated the role of macrophage and tissue monocyte in process of the inflammatory remodeling of interstitial renal tissue. Different cell signals affects interstitial tissue and activates fibroblast ploliferation and interstitial volume increasing. Cytokines such us monocyte chemotactic peptide-1, epidermal growth factor, macrophage colony stimulating factor, transforming growth factor-β1plays important role within process renal scaring and remodeling. Urinary tract infection causes expressed medullar renal scaring by toxins and inductive endogenic cytokines.
About the Author
M. M. Batyushin
Department of Internal Disease with Physiotherapy №2, Problematic Science Laboratory of Experimental Nephrology Rostov State Medical University, Rostov-on-Don South Federal University, Science Institution of Biology
Russian Federation
Russian Federation
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For citations:
Batyushin M.M. MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY. Urology Herald. 2013;(2):43-51. (In Russ.) https://doi.org/10.21886/2308-6424-2013-0-2-43-51
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