МЕХАНИЗМЫ ПОВРЕЖДЕНИЯ ПОЧЕЧНОЙ ПАРЕНХИМЫ ПРИ РЕФЛЮКС-НЕФРОПАТИИ
https://doi.org/10.21886/2308-6424-2013-0-2-43-51
Аннотация
В статье представлены пути патогенеза повреждения почечной ткани в результате везико-уретерального рефлюкса. Автором показана роль макрофагов и тканевых моноци- тов в процессе воспалительного ремоделирования интерстициальной почечной ткани. Клеточные сигналы, воздействуя на интерстициальную ткань, активизируют пролифи- рацию фибробластов и приводят к увеличению интерстициального объема. Цитокины, такие как моноцитарный хемотаксический пептид-1, эпидермальный фактор роста, макрофагальный колониестимулирующий фактор, трансформирующий фактор роста β играют важную роль в процессах повреждения и перестройки почечной ткани. Инфекции мочевых путей приводят к выраженным медуллярным почечным повреждениям путем воздействия токсинов и индуктивных эндогенных цитокинов.
Об авторе
М. М. Батюшин
Кафедра внутренних болезней с основами физиотерапии №2,
Проблемная научная лаборатория экспериментальной нефрологии
ГБОУ ВПО РостГМУ Минздрава России, г.Ростов-на-Дону
ФГАОУ ВПО «Южный федеральный университет»,
Научно-исследовательский институт биологии
Россия
Россия
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Рецензия
Для цитирования:
Батюшин М.М. МЕХАНИЗМЫ ПОВРЕЖДЕНИЯ ПОЧЕЧНОЙ ПАРЕНХИМЫ ПРИ РЕФЛЮКС-НЕФРОПАТИИ. Вестник урологии. 2013;(2):43-51. https://doi.org/10.21886/2308-6424-2013-0-2-43-51
For citation:
Batyushin M.M. MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY. Urology Herald. 2013;(2):43-51. (In Russ.) https://doi.org/10.21886/2308-6424-2013-0-2-43-51
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