Preview

Urology Herald

Advanced search

LONG-TERM RESULTS OF EXTERNAL BEAM RADIATION THERAPY IN MEN WITH NEWLY DIAGNOSED PROSTATE CANCER WITH DIFFERENT RISK OF PROGRESSION

https://doi.org/10.21886/2308-6424-2015-0-3-42-53

Abstract

The goal of the study was to evaluate cancer-specific survival in men with newly diagnosed prostate cancer after external beam radiotherapy. The long-term results of 178 patients treated with 3D-confirmal radiotherapy at N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus in 2005-2008 were analyzed. According to prostate-specific antigen level, clinical stage and Gleason sum patients were stratified into four groups of progression. 9-years cancerspecific survival in patients with low, intermediate, high and very high risk was 81,3±0,1%, 94,3±0,04%, 63,4±0,1% and 49,1±0,09%, respectively (р < 0,005).

About the Authors

P. D. Demeshko
N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
Belarus


S. A. Krasny
N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
Belarus


References

1. Океанов, А.Е. Статистика онкологических заболеваний в Республике Беларусь (2003-2012) / А.Е. Океанов, П.И. Моисеев, Л.Ф. Левин ; Под редакцией О.Г. Суконко. – Минск : РНПЦ ОМР им. Н.Н. Александрова, 2013. – 373 с.

2. Biochemical outcome after radical prostatec- tomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. / A.V.D’Amico R.Whittington, S.B. Malkowicz et al. // JAMA – 1998. – Vol. 280. – P. 969-974.

3. Prostate cancer, version 2.2014 / J.L. Mohler, P.W. Kantoff, A.J. Armstrong et al. // J. Natl. Compr. Canc. Netw. – 2014. – Vol. 12 (5). – P. 686-718.

4. Predicting recurrence after radical prostatectomy for patients with high risk prostate cancer / G.D. Grossfeld, D.M. Latini, D.P. Lubeck et al. // J Urol. – 2003. – Vol. 169. – P.157–163.

5. Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy / O. Yossepowitch, S.E. Eggener, A.M. Serio et al. // Eur. Urol. – 2008. – Vol. 53. – P. 950–959.

6. Cooperberg, M.R. Time trends and local variation in primary treatment of localized prostate cancer / M.R. Cooperberg, J.M. Broering, P.R. Carroll // J Clin. Oncol. – 2010. – Vol. 28. – P.1117–1123.

7. Multimodal treatment for high-risk prostate cancer with high-dose intensitymodulated radiation therapy preceded or not by radical prostatectomy, concurrent intensified-dose docetaxel and long-term androgen deprivation therapy: results of a prospective phase II trial / A. Guttilla, R. Bortolus, G. Giannarini et al. // Radiation Oncology – 2014. – Vol. 9. – P. 24-34.

8. Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group / P. Grimm, I. Billiet, D. Bostwick et al. // BJU Int. – 2012. – Vol. 109 (Suppl. 1). – P. 22-29.

9. Natural history of progression after PSA elevation following radical prostatectomy / C.R. Pound, A.W. Partin, M.A. Eisenberger et al. // J.A.M.A. – 1999. – Vol. 281 (17). – P. 1591–1597.

10. Comparative effectiveness of radical prostatectomy and radiotherapy in prostate cancer: observational study of mortality outcomes / P. Sooriakumaran, T. Nyberg, O. Akre et al. // B.M.J. – 2014. – Vol. 26. – P. 348.

11. High-dose-rate brachytherapy as monotherapy for prostate cancer: technique, rationale and perspective / Y. Yoshioka, O. Suzuki, Y. Otani et al.// J. Contemp. Brachytherapy. – 2014. – Vol. 6. – P. 91-98.

12. Long-term results of the Dutch randomized prostate cancer trial: Impact of dose-escalation on local, biochemical, clinical failure, and survival / W.D. Heemsbergena, A. Al-Mamganib, A. Slotc et al. // Lebesque Radiotherapy and Oncology. – 2014. – Vol. 110. – P. 104–109.

13. Escalated dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial / D.P. Dearnaley, G. Jovic, I. Syndikus et al. // Lancet Oncol. – 2014. – Vol. 15. – P. 464–473.

14. Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes / M.J. Zelefsky, Y. Yamada, Z. Fuks et al. // Int. J. Radiat. Oncol. Biol. Phys. – 2008. – Vol. 71. – P. 1028-1033.


Review

For citations:


Demeshko P.D., Krasny S.A. LONG-TERM RESULTS OF EXTERNAL BEAM RADIATION THERAPY IN MEN WITH NEWLY DIAGNOSED PROSTATE CANCER WITH DIFFERENT RISK OF PROGRESSION. Urology Herald. 2015;(3):42-53. (In Russ.) https://doi.org/10.21886/2308-6424-2015-0-3-42-53

Views: 1659


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2308-6424 (Online)