«URAT-INDEX» – NON-INVASIVE TOOL FOR PREDICTION OF URIC ACID CONTAINING STONES
N. K. Gadzhiev,
M. M. Iziev,
D. S. Gorelov,
G. S. Akopyan,
A. N. Arsenyev,
P. M. Rubin,
A. S. Chislov,
S. B. Petrov https://doi.org/10.21886/2308-6424-2017-5-4-22-28
Abstract
Background. Nowadays dissolution of uric acid kidney stones is the first line treatment according to existing clinical guidelines. Besides dual-energy CT, which is costly, there is no non-invasive tool to predict uric acid stone composition.
Aim. To develop a new tool for uric acid stones prediction which will improve patient selection for oral stone dissolution therapy.
Materials and methods. We retrospectively analyzed treatment results of 189 patients which were distributed to two groups: with pure uric acid stones - 59 patients and with other composition - 130 patients. Demographic data, results of 24 hour urine analysis and CT scans were analyzed.
Results. Among above mentioned parameters the following had the highest significance: body mass, body mass index, urine pH and stone density in Hounsfield Units (p<0.01). Product of multiplication of urine pH and CT-stone density called «Urate index» yielded highest AUC (0.96) which permitted with high accuracy diagnose uric acid stones.
Conclusion. «Urate-index» is simple to obtain and has high predictive value which might help choosing target population for kidney stone dissolution.
About the Authors
N. K. Gadzhiev
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of the Department of SWL and Endovideosurgery. Research Center of Urology,
Saint-Petersburg
M. M. Iziev
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
postgraduate student of the Department of Urology,
Saint-Petersburg
D. S. Gorelov
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
a urologist of the Department of SWL and Endovideosurgery of the Research Center of Urology,
Saint-Petersburg
G. S. Akopyan
The First Moscow State Medical University. I. M. Sechenov
Russian Federation
Russian Federation
MD, associate professor of the Department of Urology,
MoscowA. N. Arsenyev
Tver State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor of Hospital Surgery with a course of urology,
Tver
P. M. Rubin
Tver State Medical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Assistant of the Department of Hospital Surgery with a course of urology,
Tver
A. S. Chislov
Tver State Medical University
Russian Federation
Russian Federation
clinical resident of the Department of Hospital Surgery with a course of urology,
Tver
S. B. Petrov
The Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of the Department of Urology,
Saint-Petersburg
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Review
For citations:
Gadzhiev N.K., Iziev M.M., Gorelov D.S., Akopyan G.S., Arsenyev A.N., Rubin P.M., Chislov A.S., Petrov S.B. «URAT-INDEX» – NON-INVASIVE TOOL FOR PREDICTION OF URIC ACID CONTAINING STONES. Urology Herald. 2017;5(4):22-28. (In Russ.) https://doi.org/10.21886/2308-6424-2017-5-4-22-28
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