Efficacy and safety of antibiotic therapy and prophylaxis of urinary tract infections in children with vesicoureteral reflux
https://doi.org/10.21886/2308-6424-2026-14-1-93-105
Abstract
Vesicoureteral reflux (VUR) is a common condition in paediatric urology that increases the risk of urinary tract infection (UTI), which in turn may result in renal scarring and the development of chronic kidney disease in children. A first episode of UTI is often the trigger for the diagnosis of VUR. Antibiotic therapy remains the mainstay of UTI management, while continuous antibiotic prophylaxis is used to prevent recurrence and infectious complications in children with VUR. However, prolonged antibiotic use is associated with important risks, including the development of antimicrobial resistance. This review evaluates the efficacy and safety of contemporary antibiotic treatment and prophylactic strategies in children with VUR. Particular emphasis is placed on optimizing patient management and on current guideline-based recommendations aimed at reducing recurrence rates and improving clinical outcomes.
Supporting agencies: The study was not sponsored.
About the Authors
Yu. L. Naboka
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Yulia L. Naboka — Dr.Sc.(Med), Full Prof.
Rostov-on-Don
Competing Interests:
Authors Yulia L. Naboka, Vladimir V. Sizonov, and Mikhail I. Kogan are members of the Editorial Board of Urology Herald. The article underwent the journal's standard peer-review process by independent experts. The authors declare no other conflicts of interest
E. M. Kotieva
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elizaveta M. Kotieva
Rostov-on-Don
Competing Interests:
Authors Yulia L. Naboka, Vladimir V. Sizonov, and Mikhail I. Kogan are members of the Editorial Board of Urology Herald. The article underwent the journal's standard peer-review process by independent experts. The authors declare no other conflicts of interest
V. V. Sizonov
Rostov State Medical University; Rostov Regional Children's Clinical Hospital
Russian Federation
Competing Interests:
Russian Federation
Vladimir V. Sizonov — Dr.Sc.(Med.); Full Prof.
Rostov-on-Don
Competing Interests:
Authors Yulia L. Naboka, Vladimir V. Sizonov, and Mikhail I. Kogan are members of the Editorial Board of Urology Herald. The article underwent the journal's standard peer-review process by independent experts. The authors declare no other conflicts of interest
R. A. Rodina
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Roza A. Rodina
Rostov-on-Don
Competing Interests:
Authors Yulia L. Naboka, Vladimir V. Sizonov, and Mikhail I. Kogan are members of the Editorial Board of Urology Herald. The article underwent the journal's standard peer-review process by independent experts. The authors declare no other conflicts of interest
M. I. Kogan
Rostov State Medical University
Russian Federation
Competing Interests:
Russian Federation
Mikhail I. Kogan — Dr.Sc.(Med), Full Prof., Hons. Sci. of the Russian Federation
Rostov-on-Don
Competing Interests:
Authors Yulia L. Naboka, Vladimir V. Sizonov, and Mikhail I. Kogan are members of the Editorial Board of Urology Herald. The article underwent the journal's standard peer-review process by independent experts. The authors declare no other conflicts of interest
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Naboka Yu.L., Kotieva E.M., Sizonov V.V., Rodina R.A., Kogan M.I. Efficacy and safety of antibiotic therapy and prophylaxis of urinary tract infections in children with vesicoureteral reflux. Urology Herald. 2026;14(1):93-105. (In Russ.) https://doi.org/10.21886/2308-6424-2026-14-1-93-105
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