Inflammatory myofibroblastic tumor: a rare clinical case of bladder pathology
https://doi.org/10.21886/2308-6424-2025-13-6-132-141
Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm characterized by proliferation of spindle‑shaped cells with prominent inflammatory cell infiltration. IMT is also referred to as an inflammatory pseudotumor or pseudosarcomatous myofibroblastic tumor. Although it accounts for less than 1% of all bladder tumors, the bladder is the most frequent site of IMT within the genitourinary tract. In this report, we present the case of patient M., a 1‑year‑7‑month‑old child with a 2‑month history of dysuria and painful voiding. Following a diagnostic work‑up, including ultrasound, voiding cystography, abdominal and pelvic CT, cystourethroscopy, and pelvic MRI, the child underwent surgical excision (enucleation) of the mass with negative margins. Histopathological examination confirmed the diagnosis of IMT. During 2 years of follow‑up with ultrasound, CT, and MRI, no evidence of local recurrence was detected, which is consistent with published data indicating low recurrence rates after organ‑sparing surgical management without adjuvant chemotherapy.
About the Authors
D. A. Dobroserdov
Children's City Multidisciplinary Clinical Specialized Centre of High Medical Technologies, Mechnikov North-Western State Medical University
Россия
Россия
Dmitrii A. Dobroserdov – Cand.Sc.(Med)
Saint Petersburg
M. P. Kuchinsky
Children's City Multidisciplinary Clinical Specialized Centre of High Medical Technologies
Россия
Россия
Mikhail P. Kuchinskii
Saint Petersburg
N. A. Filatova
Children's City Multidisciplinary Clinical Specialized Centre of High Medical Technologies
Россия
Россия
Natalia A. Filatova
Saint Petersburg
M. M. Kardanov
Pavlov First Saint Petersburg State Medical University
Россия
Россия
Marat M. Kardanov
Saint Petersburg
References
1. Song D, Jiao W, Gao Z, Liu N, Zhang S, Zong Y, Fang Z, Fan Y. Inflammatory myofibroblastic tumor of urinary bladder with severe hematuria: A Case report and literature review. Medicine (Baltimore). 2019;98(1):e13987. DOI: 10.1097/MD.0000000000013987
2. Gass J, Beaghler M, Kwon M. Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report. J Endourol Case Rep. 2019;5(2):31-33. DOI: 10.1089/cren.2018.0096
3. Jo VY, Fletcher CD. WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology. 2014;46(2):95-104. DOI: 10.1097/PAT.0000000000000050
4. Brunn H: Two interesting benign lung tumors of contradictory histopathology: Remarks on the Necessity for Maintaining the Chest Tumor Registry. J Thorac Surg. 1939;9(2):119-131. DOI: 10.1016/S0096-5588(20)32030-4
5. Lane JD, Krohn S, Kolozsi W, Whitehead RE. Plasma cell granuloma of lung. Dis Chest. 1955;27(2):216-221. DOI: 10.1378/chest.27.2.216
6. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol. 1991;15(12):1146-1156. DOI: 10.1097/00000478-199112000-00005
7. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19(8):859-872. DOI: 10.1097/00000478-199508000-00001
8. Harik LR, Merino C, Coindre JM, Amin MB, Pedeutour F, Weiss SW. Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases. Am J Surg Pathol. 2006;30(7):787-794. DOI: 10.1097/01.pas.0000208903.46354.6f
9. Janik JS, Janik JP, Lovell MA, Hendrickson RJ, Bensard DD, Greffe BS. Recurrent inflammatory pseudotumors in children. J Pediatr Surg. 2003;38(10):1491-1495. DOI: 10.1016/s0022-3468(03)00501-3
10. Roth JA. Reactive pseudosarcomatous response in urinary bladder. Urology. 1980;16(6):635-637. DOI: 10.1016/0090-4295(80)90578-6
11. Proppe KH, Scully RE, Rosai J. Postoperative spindle cell nodules of genitourinary tract resembling sarcomas. A report of eight cases. Am J Surg Pathol. 1984;8(2):101-8. DOI: 10.1097/00000478-198402000-00003
12. Netto JM, Pérez LM, Kelly DR, Joseph DB. Pediatric inflammatory bladder tumors: myofibroblastic and eosinophilic subtypes. J Urol. 1999;162(4):1424-9 PMID: 10492229
13. Cheng L, Foster SR, MacLennan GT, Lopez-Beltran A, Zhang S, Montironi R. Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum? J Urol. 2008;180(4):1235-1240. DOI: 10.1016/j.juro.2008.06.049
14. Horn LC, Reuter S, Biesold M. Inflammatory pseudotumor of the ureter and the urinary bladder. Pathol Res Pract. 1997;193(9):607-612. DOI: 10.1016/S0344-0338(97)80037-4
15. Mergan F, Jaubert F, Sauvat F, Hartmann O, Lortat-Jacob S, Révillon Y, Nihoul-Fékété C, Sarnacki S. Inflammatory myofibroblastic tumor in children: clinical review with anaplastic lymphoma kinase, Epstein-Barr virus, and human herpesvirus 8 detection analysis. J Pediatr Surg. 2005;40(10):1581-1586. DOI: 10.1016/j.jpedsurg.2005.06.021
16. Williamson SR, Lopez-Beltran A, MacLennan GT, Montironi R, Cheng L. Unique clinicopathologic and molecular characteristics of urinary bladder tumors in children and young adults. Urol Oncol. 2013;31(4):414-426. DOI: 10.1016/j.urolonc.2010.08.003
17. Lecuona AT, Van Wyk AC, Smit SG, Zarrabi AD, Heyns CF. Inflammatory myofibroblastic tumor of the bladder in a 3-year-old boy. Urology. 2012;79(1):215-218. DOI: 10.1016/j.urology.2011.04.052
18. Coffin CM, Alaggio R. Fibroblastic and myofibroblastic tumors in children and adolescents. Pediatr Dev Pathol. 2012;15(1 Suppl):127-180. DOI: 10.2350/10-12-0944-PB.1
19. Lopez-Nunez O, John I, Panasiti RN, Ranganathan S, Santoro L, Grélaud D, Wu T, Buccoliero AM, Casanova M, Alaggio R, Surrey LF. Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases. Mod Pathol. 2020;33(4):576-590. DOI: 10.1038/s41379-019-0406-6
20. Coffin CM, Dehner LP, Meis-Kindblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations. Semin Diagn Pathol. 1998;15(2):102-110. PMID: 9606802.
21. Souid AK, Ziemba MC, Dubansky AS, Mazur M, Oliphant M, Thomas FD, Ratner M, Sadowitz PD. Inflammatory myofibroblastic tumor in children. Cancer. 1993;72(6):2042-2048. DOI : 10 .1002/1097-0142 (19930915) 72 : 6<2042 : : a i d - cncr2820720641>3.0.co;2-i
22. Gardner MP, Lowichik A, Cartwright PC. Inflammatory (pseudosarcomatous) myofibroblastic tumor of the urinary bladder causing acute abdominal pain. J Pediatr Surg. 1999;34(9):1417-1419. DOI: 10.1016/s0022-3468(99)90025-8
23. Houben CH, Chan A, Lee KH, Tam YH, To KF, Cheng W, Yeung CK. Inflammatory myofibroblastic tumor of the bladder in children: what can be expected? Pediatr Surg Int. 2007;23(8):815-9. DOI: 10.1007/s00383-007-1885-y
24. Al-Ahmadie H, Gomez AM, Trane N, Bove KE. Giant botryoid fibroepithelial polyp of bladder with myofibroblastic stroma and cystitis cystica et glandularis. Pediatr Dev Pathol. 2003;6(2):179-181. DOI: 10.1007/s10024-002-8817-6
25. Li YP, Han WW, Yang Y, He LJ, Zhang WP. Inflammatory Myofibroblastic Tumor of the Urinary Bladder and Ureter in Children: Experience of a Tertiary Referral Center. Urology. 2020;145:229-235. DOI: 10.1016/j.urology.2020.07.050
26. Reinhart S, Trachsel Y, Fritz C, Wagner U, Bode-Lesniewska B, John H, Pless M. Inflammatory Myofibroblastic Tumor of the Bladder With FN1-ALK Gene Fusion: Different Response to ALK Inhibition. Urology. 2020;146:32-35. DOI: 10.1016/j.urology.2020.09.026
27. Fletcher SG, Galgano MT, Michalsky MP, Roth JA. Regression of inflammatory pseudotumor of the bladder in a child with medical management. Urology. 2007;69(5):982.e11-2. DOI: 10.1016/j.urology.2007.02.034
28. Xu H, He B, Tu X, Bao Y, Yang L, Zhuo H, Wei Q. Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports. Medicine (Baltimore). 2018;97(49):e13474. DOI: 10.1097/MD.0000000000013474
29. Tsuma Y, Miyachi M, Ouchi K, Tsuchiya K, Iehara T, Naitoh Y, Konishi E, Yanagisawa A, Hosoi H. Neoadjuvant Treatment With Cyclooxygenase-2 Inhibitor and Prednisolone Allows Conservative Surgery for Inflammatory Myofibroblastic Tumor of the Bladder. J Pediatr Hematol Oncol. 2016;38(8):e283-e285. DOI: 10.1097/MPH.0000000000000604
30. Raja NS, Lee T, Kaffenberger S, Kraft K, Udager A, Ivancic V. Localized Inflammatory Myofibroblastic Tumor Involving the Genitourinary System: Adolescent Case Series and Review. Urology. 2018;122:162-164. DOI: 10.1016/j.urology.2018.07.002
31. Libby EK, Ellis LT, Weinstein S, Hammer RD, Murray KS. Metastatic inflammatory myofibroblastic tumor of the bladder. Urol Case Rep. 2018;23:10-12. DOI: 10.1016/j.eucr.2018.11.007
32. Yi XL, Lu HY, Wu YX, Li WH, Meng QG, Cheng JW, Tang Y, Liu Y, Bai XZ. Inflammatory myofibroblastic tumor with extensive involvement of the bladder in an adolescent: a case report. World J Surg Oncol. 2013;11:206. DOI: 10.1186/1477-7819-11-206
33. Wang X, Xu S, Tang D, Gu W, Shu Q. Malignant Inflammatory Myofibroblastic Tumor of the Urinary Bladder in a 14-Year-Old Boy. J Pediatr Hematol Oncol. 2015;37(7):e402-e404. DOI: 10.1097/MPH.0000000000000398
Review
For citations:
Dobroserdov D.A., Kuchinsky M.P., Filatova N.A., Kardanov M.M. Inflammatory myofibroblastic tumor: a rare clinical case of bladder pathology. Urology Herald. 2025;13(6):132-141. (In Russ.) https://doi.org/10.21886/2308-6424-2025-13-6-132-141
Views:
40
JATS XML
Email this article 