The problem of recurrent infection of the lower urinary tract remains one of the most acute issues in urology [1]. 1 out of 3 women by the age of 24 had a minimum of one episode of acute cystitis according to statistical data, and in half of them, this process becomes recurrent [1][2][3]. Postcoital cystitis is observed in 60% of cases of recurrent infections of the lower urinary tract [4].

Female hypospadias and urethral hypermobility, presence of urethral-hymenal adhesions, and a degree of sexual activity are some of the most frequent causes of postcoital dysuria [5][6][7]. Urethral-hymenal adhesions are congenital adhesions or fusions between the residuals of the hymen of different shapes and sizes and the walls of the external urethral orifice [8].

Postcoital dysuria is a psychological problem often rather than medical [9][10]. Low efficacy of conservative therapy and long-term course of the disease lead to emotional and psychic disorders. Some patients who have a recurrence and dyspareunia after each sexual intercourse have to refuse sexual life. There are different modifications of surgical treatment for female hypospadias. The methods aim to limit the mobility of the urethra during intercourse, maximally transposition the urethral orifice from the vaginal opening to the clitoris [10]. Low traumatic isolated removal of urethral-hymenal adhesions is low effective [11][12]. Traditional urethral transposition has such significant disadvantages as traumatization of the vaginal opening, paraurethral, and paraclitoral tissues during the mobilization and distal urethral transposition [13][14]. The invasiveness of these surgeries can result in the appearance of cicatricle changes in the vaginal opening, dyspareunia, and anorgasmia [14][15]. It is necessary to search for new low invasive and less traumatic methods that are as effective as urethral transposition. The study aimed to evaluate the effectiveness and safety of the combined minimally invasive method of treatment for female hypospadias and urethral hypermobility ― removal of urethral-hymenal adhesions and paraurethral implantation of a filler.

83 patients aged 17 ‒ 40 years old with female hypospadias and urethral hypermobility complicated by postcoital dysuria have been treated since 2015. The disease onset was registered with the beginning of sexual life in 60 (80%) women out of 83, with the beginning of regular sexual life ― in 15 (20%) women. The examination showed that all women had urethral-hymenal adhesions, positive O᾽Donnell-Hirschhorn test, and vaginal dystopia of the urethra. One patient had a previous urethral transposition that had a temporary effect. All women underwent surgical treatment. They had urethral-hymenal adhesions dissected and received a suburethral injection of hyaluronic acid filler according to the patented method (patent for invention No. 2660993 dated July 11, 2018).

The method consists of 2 stages. The first stage includes a dissection of urethral-hymenal adhesions. For this, the residuals of the hymen and urethral-hymenal adhesions were removed (Fig. 1A, 1B). The wound was sutured with two continuous absorbable sutures Vicryl 5 – 6/0 (Fig. 2).

The disease onset was registered with the beginning of regular sexual life in 50 patients. Cystitis manifested right after the first sexual intercourse in 32 patients.

The quality of life, evaluated through a survey (questionnaires UDI-6 + PISQ-12 (Sexual Questionnaire), improved in 74 patients (89%) (p < 0.05) (Fig. 4, 5).

Hirschhorn described urethral-hymenal adhesions (residuals of the hymen) as the cause of postcoital cystitis in 1965 [10]. The urethra involved in the sclerotic process forms a common adhesion with the residuals of the hymen. Significant hymenal adhesions are closely connected with the distal urethra. They contribute to the urethral invagination during intercourse due to their sizes and lead to painful sexual intercourse, which reduces the quality of life of patients. Transposition of the urethral outer orifice into the vagina occurs during frictions. This leads to a retrograde penetration of the vaginal microflora into the urethra, which is a constant source of infection of the lower urinary tract [10]. Besides, excessive (hypertrophied) residuals of the hymen tightly close the vaginal opening, which can provoke the development of chronic vulvovaginitis because of the lack of oxygen [11]. Taking into account a common lymphatic collector, such conditions aggravate the risks of persisting inflammation of the lower urinary duct. As a result, persistent chronic “postcoital cystitis” develops [12].

O’Donnel, who connected the disease with ectopia of the urethra, proposed a surgical technique on the urethral outer orifice transposition in the case of its ectopia from the vagina to the paraclitoral area in 1968. The method was called a urethral transposition [13].

Several modifications of the urethral transposition have been developed. The main techniques include extravaginal urethral transposition [6], distal urethral transposition [14], and urethral meatus transposition [15][16]. The proposed methods are based on the outer urethral orifice transposition from the vaginal opening towards the clitoris. However, these techniques are associated with excessive tissue traumatization, which can lead to the formation of cicatrices in the vaginal opening, innervation impairment, tunnel syndromes, strictures, tension, and urethral detachment [17]. According to other authors, surgical intervention in the paraclitoral area is also associated with the development of chronic pelvic pain syndrome, dyspareunia, and anorgasmia [18][19].

Complications after reconstructive and esthetic surgeries on the vaginal opening and paraclitoral areas in adults and adolescents raise concern in the American Association of Obstetricians and Gynecologists [20]. There are presently not enough studies on long-term results that show the satisfaction of patients in the postoperative period, safety, and rate of complications [20].

Ampt (2013) performed a 10-year analysis of complications after surgeries on the vaginal opening. The rate of complications was 7.2%. The most frequent complications included non-specific inflammatory changes of the lower urinary tract, dyspareunia, and long-term pain syndrome in the area of postoperative wounds. Each 23rd observation required repeated surgical intervention because of poor wound regeneration or unsatisfactory treatment results [21].

The proposed method included 2 components: dissection of urethral-hymenal adhesions and restoration of normal anatomy of the urethra through the injection of the filler (bulk gel). Atraumatic distal urethral meatus transposition is provided by the formation of a gel pad. The mobility of the distal urethra decreases and the distance from the vaginal opening to the urethra orifice increases. The separation of the meatus and the vaginal opening by dissection of urethral-hymenal adhesions and residuals of the hymen and the injection of the filler leads to a significant decrease in the degree of urethral invagination during coitus.

Additional therapeutic mechanism during the formation of a gel pad includes a stop (limitation) of lymphogenic exchange between the vagina and the lower urinary tract, which decreases the risk and degree of postcoital inflammation of the urinary tract.

The results of the present study demonstrate the high effectiveness of the treatment for female hypospadias and hypermobility of the urethra complicated by postcoital dysuria. The recurrence was observed only after natural biodegradation of the filler. The questionnaires UDI-6 and PISQ-12 provided evidence of subjective improvement in the condition of patients after surgery.

The main drawback of the proposed method is the natural biodegradation of the bulk gel, which may require repeated injection. It was observed in eight patients in the present study (12.7%). Still, the repeated manipulation can be made under local anesthesia in outpatient conditions. The method is characterized by the lack of intra- and postoperative complications. The worsening of the quality of life and sexual function was not registered.

The proprietary method improves the results of the treatment of patients with hypospadias and hypermobility of the urethra, complicated by postcoital dysuria, with a minimum risk of complications. Taking into account the lack of complications and minimally invasive character, the dissection of the urethral-hymenal adhesion and injection of the filler can become the method of first-line in women with postcoital cystitis. The method is not associated with significant tissue fibrosis, and as a result, does not increase the technical complexity and risks of traditional urethral transposition if it is required in the future. The drawback of the method is the natural biodegradation of the filler (bulk gel), which may require its re-implantation.