urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2013-0-2-3-9urovest-9Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОТДАЛЕННЫЕ РЕЗУЛЬТАТЫ ИММУНОПРОФИЛАКТИКИ РЕЦИДИВОВ ИНФЕКЦИЙ УРОГЕНИТАЛЬНОГО ТРАКТАLONG-TERM RESULTS OF IMMUNOPROPHYLAXIS RECURRENT INFECTION OF THE UROGENITAL TRACTКульчавеняЕ. В.KulchavenyaE. V.БреусовА. А.BreusovA. A.urotub@yandex.ruФГБУ Новосибирский НИИ туберкулеза Минздрава России, г.Новосибирск ГБОУ ВПО Новосибирский государственный медицинский университет Минздрава России, г.НовосибирскРоссияNovosibirsk Research Institute of Tuberculosis, Novosibirsk Novosibirsk State Medical University, NovosibirskRussian FederationМедицинский центр «БИОВЭР»РоссияMedical center «BIOVER», NovosibirskRussian Federation2013200620130239Copyright © Кульчавеня Е.В., Бреусов А.А., 20132013Кульчавеня Е.В., Бреусов А.А.Kulchavenya E.V., Breusov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/9

В наше исследование включено 48 пациентов, получивших первый курс Уро-Ваксома в 2007-2008 годах: 19 мужчин с хроническим бактериальным простатитом/уретро- простатитом, и 29 женщин, страдающих рецидивирующим циститом. Всего за пять лет было отмечено 125 рецидивов урогенитальной инфекции; при этом 88 случаев (70,4%) по- требовали наряду с Уро-Ваксомом приема антибиотиков или уросептиков в сочетании с фитопрепаратами, а в остальных 37-и случаях (29,6%) монотерапии Уро-Ваксомом ока- залось достаточно для купирования воспаления. За пять лет проведено 254 месячных кур- са Уро-Ваксома; из них 125 (49,2%) с лечебной целью по поводу рецидива урогенитальной инфекции, а 129 (50,8%) – с профилактической, вне обострения основного заболевания. Основные показания – интеркуррентная инфекция, преимущественно респираторная (86 случаев – 66,7%), стресс (14 случаев – 10,8%), в 29-и случаях (22,5%) пациенты прини- мали Уро-Ваксом самостоятельно, без назначения врача, ориентируясь на свои ощущения.

Our study included 48 patients who received a first course of Uro-Vaxom in 2007-2008, 19 men with chronic prostatitis/urethroprostatitis, and 29 women with recurrent cystitis. In just five years, it was noted 125 recurrences of urogenital infections, of which 88 cases (70,4%) is required in addition to Uro-Vaxom antibiotics in combination with herbal medicine, and in the remaining 37 cases, and (29,6%), Uro-Vaxom alone was enough to relieve inflammation. In five years there were 254 monthly rate of Uro-Vaxom, of whom 125 (49,2%) with curative intent for recurrent urogenital infections, and 129 (50,8%) – from preventive, without exacerbation of underlying disease. Key for Punishment - intercurrent infection, mainly respiratory (86 cases – 66,7%), stress (14 cases – 10,8%) in the 29 and the cases (22,5%) patients received Uro-Vaxom alone, without a doctor's prescription , focusing on the sensations.

инфекцииурогенитальныеиммунопрофилактикаinfectionurogenitalimmunoprophylaxisReferencesImmunoactive prophylaxis of recurrent urinary tract infections: a metaanalysis. / K.G. Naber, Y.H. Cho, T. Matsumoto, A.S. Schaeffer // Int. J. Antimicrob. Agents. – 2009. – Feb; Vol.33(2). – P.111-119.Immunoactive prophylaxis of recurrent urinary tract infections: a metaanalysis. / K.G. Naber, Y.H. Cho, T. Matsumoto, A.S. Schaeffer // Int. J. Antimicrob. Agents. – 2009. – Feb; Vol.33(2). – P.111-119.Krieger, J.N. Urinary tract infections: what’s new? / J.N. Krieger // J. Urol. – 2002.– Vol.168. – P.2351-2358.Krieger, J.N. Urinary tract infections: what’s new? / J.N. Krieger // J. Urol. – 2002.– Vol.168. – P.2351-2358.Nicolle, L.E. Asymptomatic bacteriuria in the elderly / L.E. Nicolle // Infect. Dis. Clin. North. Am. – 1997. – Vol.11. – P.647-662.Nicolle, L.E. Asymptomatic bacteriuria in the elderly / L.E. Nicolle // Infect. Dis. Clin. North. Am. – 1997. – Vol.11. – P.647-662.A prospective Multi-center Trial of Escherichia coli extract for the prophylactic treatment of patients with chronically recurrent cystitis / Kun Suk Kim, JiYoon Kim, In Gab Jeong et al. // J. Korean Med. Sci. – 2010. – Vol.25. – P.435-439.A prospective Multi-center Trial of Escherichia coli extract for the prophylactic treatment of patients with chronically recurrent cystitis / Kun Suk Kim, JiYoon Kim, In Gab Jeong et al. // J. Korean Med. Sci. – 2010. – Vol.25. – P.435-439.Immunostimulation by bacterial components: II. Efficacy studies and meta-analysis of the bacterial extract OM-89 / M. Huber, K. Krauter, G. Winkelmann et al. // Int. J. of Immunopharmacology 2000. – Vol.22. – P.1103-1111.Immunostimulation by bacterial components: II. Efficacy studies and meta-analysis of the bacterial extract OM-89 / M. Huber, K. Krauter, G. Winkelmann et al. // Int. J. of Immunopharmacology 2000. – Vol.22. – P.1103-1111.Prevention of recurrent urinary tract infections with immuno-active E.Coli fractions: a meta-analysis of five placebocontrolled double-blind studies / H.W. Bauer, W. Rahls, P.A. Lauener, G.S. Plessmann // Int. J. Antimicrob. Agents. – 2002. – June; Vol.19(6). – P.451-456.Prevention of recurrent urinary tract infections with immuno-active E.Coli fractions: a meta-analysis of five placebocontrolled double-blind studies / H.W. Bauer, W. Rahls, P.A. Lauener, G.S. Plessmann // Int. J. Antimicrob. Agents. – 2002. – June; Vol.19(6). – P.451-456.Oral immunotherapy of recurrent urinary tract infections: a double-blind placebo-controlled multicenter study / C.C. Schulman, A. Corbusier, H. Michiels, H.J. Taenzer // J. Urol. – 1993. – Vol.150. – P.917-921.Oral immunotherapy of recurrent urinary tract infections: a double-blind placebo-controlled multicenter study / C.C. Schulman, A. Corbusier, H. Michiels, H.J. Taenzer // J. Urol. – 1993. – Vol.150. – P.917-921.Uro-Vaxom and the management of recurrent urinary tract infection in adults: a randomizes multicenter double-blind trial / P. Magasi, J. Panovics, A. Illes, M. Nagy // Europ. Urol. – 1994. Vol.26. – P.137-140.Uro-Vaxom and the management of recurrent urinary tract infection in adults: a randomizes multicenter double-blind trial / P. Magasi, J. Panovics, A. Illes, M. Nagy // Europ. Urol. – 1994. Vol.26. – P.137-140.Hachen, H.J. Oral immunotherapy in paraplegic patients with chronic urinary tract infections: a double-blind, placebo-controlled trial / H.J. Hachen // J. Urol. – 1990. – Vol.143 – P.759-763.Hachen, H.J. Oral immunotherapy in paraplegic patients with chronic urinary tract infections: a double-blind, placebo-controlled trial / H.J. Hachen // J. Urol. – 1990. – Vol.143 – P.759-763.Tammen, H. German urinary tract infection study group. Immunobiotherapy with Uro-Vaxom in recurrent urinary tract infection / H. Tammen // Br. J. Urol. – 1990. – Vol.65. – P.6-9.Tammen, H. German urinary tract infection study group. Immunobiotherapy with Uro-Vaxom in recurrent urinary tract infection / H. Tammen // Br. J. Urol. – 1990. – Vol.65. – P.6-9.Schneider, H.J. New therapeutic approach for recurrent urinary tract infections. Marked reduction in recurrence rate in women with uncomplicated cystitis – few side effects, high compliance / H.J. Schneider // Der Allgemeinarzt – 1990. – Vol.12. – P.626-633.Schneider, H.J. New therapeutic approach for recurrent urinary tract infections. Marked reduction in recurrence rate in women with uncomplicated cystitis – few side effects, high compliance / H.J. Schneider // Der Allgemeinarzt – 1990. – Vol.12. – P.626-633.Rezidivierende Harnwegsinfektionen in der Postmenopause. Wirksamkeit einer oralen Immuntherapie mit E. Colifraktionen / G. Popa, K.D. Lauber, H. Rothe, E. Rugendorff // Munch. Med. Wschr. – 1996. – Vol.138. P.713-716.Rezidivierende Harnwegsinfektionen in der Postmenopause. Wirksamkeit einer oralen Immuntherapie mit E. Colifraktionen / G. Popa, K.D. Lauber, H. Rothe, E. Rugendorff // Munch. Med. Wschr. – 1996. – Vol.138. P.713-716.An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells / S. Schmidhammer, R. Ramoner, L. Holtl et al. / /Urology. – 2002. – Vol.(3)606. – P.521-526.An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells / S. Schmidhammer, R. Ramoner, L. Holtl et al. / /Urology. – 2002. – Vol.(3)606. – P.521-526.Thilagarajah, R. Quantitative hystopathology can aid diagnosis in painful bladder syndrome / R. Thilagarajah, R.O. Witherow, M.M. Walker // J. Clin. Pathol. – 1998. – Vol.51. – P.211-214.Thilagarajah, R. Quantitative hystopathology can aid diagnosis in painful bladder syndrome / R. Thilagarajah, R.O. Witherow, M.M. Walker // J. Clin. Pathol. – 1998. – Vol.51. – P.211-214.Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo / W.G, Bessler, U. vor dem Esche, A. Zgaga-Griesz, R. Ataullakhanov // Arzneimittelforschung. – 2010. – Vol.60(6). – P.324-329.Immunostimulatory properties of the bacterial extract OM-89 in vitro and in vivo / W.G, Bessler, U. vor dem Esche, A. Zgaga-Griesz, R. Ataullakhanov // Arzneimittelforschung. – 2010. – Vol.60(6). – P.324-329.Multicenter UTI Study Group. A long-term, multicenter, double-blind study of an Escherichia coli extract (OM- 89) in female patients with recurrent urinary tract infections / H.W. Bauer, S. Alloussi, G. Egger et al. // Eur. Urol. – 2005. – Apr, Vol.47(4). – P.542-548, discussion 548. (Epub 2005 Jan 21).Multicenter UTI Study Group. A long-term, multicenter, double-blind study of an Escherichia coli extract (OM- 89) in female patients with recurrent urinary tract infections / H.W. Bauer, S. Alloussi, G. Egger et al. // Eur. Urol. – 2005. – Apr, Vol.47(4). – P.542-548, discussion 548. (Epub 2005 Jan 21).Кульчавеня, Е.В. Эффективность уроваксома при рецидивирующих инфекционно-воспалительных заболеваниях мочеполовой системы / Е.В. Кульчавеня, А.А. Бреусов // Урология. – 2011. – №4. – С.7-11.Кульчавеня, Е.В. Эффективность уроваксома при рецидивирующих инфекционно-воспалительных заболеваниях мочеполовой системы / Е.В. Кульчавеня, А.А. Бреусов // Урология. – 2011. – №4. – С.7-11.

The authors declare that there are no conflicts of interest present.