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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urovest</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник урологии</journal-title><trans-title-group xml:lang="en"><trans-title>Urology Herald</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2308-6424</issn><publisher><publisher-name>Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2308-6424-2024-12-1-143-151</article-id><article-id custom-type="elpub" pub-id-type="custom">urovest-838</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБМЕН ПРАКТИЧЕСКИМ ОПЫТОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXCHANGE OF PRACTICAL EXPERIENCE</subject></subj-group></article-categories><title-group><article-title>Гангрена Fournier у больных туберкулёзом</article-title><trans-title-group xml:lang="en"><trans-title>Fournier gangrene in tuberculosis patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8060-6691</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корчагин</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Korchagin</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Михаил Павлович Корчагин — ординатор кафедры урологии; сотрудник</p><p>Москва</p></bio><bio xml:lang="en"><p>Mikhail P. Korchagin — Resident, Dept. of Urology; Employee</p><p>Moscow</p></bio><email xlink:type="simple">mihailsun@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8035-3206</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прокопович</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokopovich</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максим Александрович Прокопович — канд. мед. наук; заведующий туберкулезным внелегочным отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Maxim A. Prokopovich — M.D., Cand.Sc.(Med); Head, Tuberculosis Extrapulmonary Division</p><p>Moscow</p><p>   </p></bio><email xlink:type="simple">maximprokopovich@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский городской научно-практический центр борьбы с туберкулёзом; Российский университет медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine; Moscow Research Clinical Centre for Tuberculosis Control</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский городской научно-практический центр борьбы с туберкулёзом</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Research Clinical Centre for Tuberculosis Control</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2024</year></pub-date><volume>12</volume><issue>1</issue><fpage>143</fpage><lpage>151</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Корчагин М.П., Прокопович М.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Корчагин М.П., Прокопович М.А.</copyright-holder><copyright-holder xml:lang="en">Korchagin M.P., Prokopovich M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.urovest.ru/jour/article/view/838">https://www.urovest.ru/jour/article/view/838</self-uri><abstract><sec><title>Введение</title><p>Введение. Гангрена Fournier является опасной для жизни формой некротизирующей инфекции промежности, характеризующейся поражением пациентов с ослабленным иммунитетом, в том числе лиц с туберкулёзом.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Оценить результаты лечения пациентов с гангреной Fournier на фоне туберкулёзного процесса.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Ретроспективно сплошным методом проанализированы пять историй болезни пациентов туберкулёзного внелёгочного отделения Клиники №2 ГБУЗ «МНПЦ борьбы с туберкулёзом ДЗМ» в период с 2012 по 2022 годы с диагнозом «Гангрена Fournier». В работе применяли Шкалу оценки индекса тяжести гангрены Fournier / The Fournier’s Gangrene Severity Index (FGSI).</p></sec><sec><title>Результаты</title><p>Результаты. Анализ историй болезней раскрыл главные нюансы и особенности ведения пациентов с гангреной Fournier, фоновым процессом для которых стала туберкулёзная инфекция. Наш клинический опыт подтверждает роль Mycobacterium tuberculosis как специфического агента, а также фактора иммуносупрессии в развитии гангрены Fournier. Следует иметь насторожённость в отношении данной патологии у пациентов с туберкулёзом. Агрессивный характер инфекционного процесса диктует необходимость раннего выявления данного заболевания для проведения грамотного комплексного лечения, включающего в себя санацию хронических очагов инфекции у пациентов с урогенитальной патологией и реконструктивно-пластические методики оперативного лечения.</p></sec><sec><title>Заключение</title><p>Заключение. Гангрена Fournier у больных туберкулёзом является редким заболеванием, трудно поддающимся лечению, сопровождающийся в большинстве случаев септическим шоком и высоким риском летальности. Насторожённость в отношении гангрены Fournier у пациентов с туберкулёзом, правильно выбранная тактика лечения уменьшает риск летальных исходов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Fournier gangrene is a life-threatening form of perineal necrotizing infection characterised by affecting immucompromised patients, including those with tuberculosis.</p></sec><sec><title>Objective</title><p>Objective. To evaluate the treatment results of patients with Fournier gangrene and tuberculosis process.</p></sec><sec><title>Materials &amp; methods</title><p>Materials &amp; methods. Five case histories of patients diagnosed with "Fournier gangrene" at the Tuberculosis Extrapulmonary Division of Clinic No. 2, Moscow Research Clinical Centre for Tuberculosis Control from 2012 to 2022 were analysed retrospectively using the continuous method. The Fournier's Gangrene Severity Index (FGSI) was used for assessment.</p></sec><sec><title>Results</title><p>Results. The analysis of case histories revealed the main features of management in patients with Fournier gangrene whose underlying process was tuberculosis. Our clinical experience confirms the role of Mycobacterium tuberculosis as a specific agent, as well as an immunosuppression factor in the development of Fournier’s gangrene. One should be wary of this pathology in patients with tuberculosis. The aggressive nature of the infectious process dictates the need for early detection of this disease for competent comprehensive treatment, including early rehabilitation of chronic foci of infection in patients with urogenital pathology and reconstructive-plastic methods of surgical treatment.</p></sec><sec><title>Conclusion</title><p>Conclusion. Fournier gangrene in tuberculosis patients is a rare difficult-to-treat disease accompanied in most cases by septic shock and a high mortality risk. Alertness towards Fournier gangrene in patients with tuberculosis, correctly chosen treatment tactics reduces the risk of lethal outcomes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гангрена Fournier</kwd><kwd>урогенитальный туберкулёз</kwd><kwd>урология</kwd><kwd>флегмона промежности</kwd><kwd>реконструктивно-пластические операции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Fournier gangrene</kwd><kwd>urogenital tuberculosis</kwd><kwd>urology</kwd><kwd>perineal cellulitis</kwd><kwd>reconstructive plastic surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Giuliano A, Lewis F Jr, Hadley K, Blaisdell FW. Bacteriology of necrotizing fasciitis. Am J Surg. 1977;134(1):52-57. DOI: 10.1016/0002-9610(77)90283-5</mixed-citation><mixed-citation xml:lang="en">Giuliano A, Lewis F Jr, Hadley K, Blaisdell FW. Bacteriology of necrotizing fasciitis. Am J Surg. 1977;134(1):52-57. DOI: 10.1016/0002-9610(77)90283-5</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Vaz I. Fournier gangrene. Trop Doct. 2006;36(4):203-204. DOI: 10.1258/004947506778604724</mixed-citation><mixed-citation xml:lang="en">Vaz I. Fournier gangrene. Trop Doct. 2006;36(4):203-204. DOI: 10.1258/004947506778604724</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fournier JA. Jean-Alfred Fournier 1832-1914. Gangrène foudroyante de la verge (overwhelming gangrene). Sem Med 1883. Dis Colon Rectum. 1988;31(12):984-8. DOI: 10.1007/BF02554904</mixed-citation><mixed-citation xml:lang="en">Fournier JA. Jean-Alfred Fournier 1832-1914. Gangrène foudroyante de la verge (overwhelming gangrene). Sem Med 1883. Dis Colon Rectum. 1988;31(12):984-8. DOI: 10.1007/BF02554904</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Eke N. Fournier's gangrene: a review of 1726 cases. Br J Surg. 2000;87(6):718-728. DOI: 10.1046/j.1365-2168.2000.01497.x</mixed-citation><mixed-citation xml:lang="en">Eke N. Fournier's gangrene: a review of 1726 cases. Br J Surg. 2000;87(6):718-728. DOI: 10.1046/j.1365-2168.2000.01497.x</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sorensen MD, Krieger JN, Rivara FP, Broghammer JA, Klein MB, Mack CD, Wessells H. Fournier's Gangrene: population based epidemiology and outcomes. J Urol. 2009;181(5):2120-2126. DOI: 10.1016/j.juro.2009.01.034</mixed-citation><mixed-citation xml:lang="en">Sorensen MD, Krieger JN, Rivara FP, Broghammer JA, Klein MB, Mack CD, Wessells H. Fournier's Gangrene: population based epidemiology and outcomes. J Urol. 2009;181(5):2120-2126. DOI: 10.1016/j.juro.2009.01.034</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wang YK, Li YH, Wu ST, Meng E. Fournier's gangrene. QJM. 2017;110(10):671-672. DOI: 10.1093/qjmed/hcx124</mixed-citation><mixed-citation xml:lang="en">Wang YK, Li YH, Wu ST, Meng E. Fournier's gangrene. QJM. 2017;110(10):671-672. DOI: 10.1093/qjmed/hcx124</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, Mahmoud MU, Bin-Jumah M, Alkahtani S, Abdel-Daim MM. Fournier's gangrene mortality: A 17-year systematic review and meta-analysis. Int J Infect Dis. 2020;92:218-225. DOI: 10.1016/j.ijid.2019.12.030</mixed-citation><mixed-citation xml:lang="en">El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, Mahmoud MU, Bin-Jumah M, Alkahtani S, Abdel-Daim MM. Fournier's gangrene mortality: A 17-year systematic review and meta-analysis. Int J Infect Dis. 2020;92:218-225. DOI: 10.1016/j.ijid.2019.12.030</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bispen AV, Zuban' ON, Iagafarova RK. Bolezn' Furn'e i tuberkulez polovykh organov [Fournier disease and genital tuberculosis]. Probl Tuberk. 1999;(6):57-58. (In Russian). PMID: 10715966</mixed-citation><mixed-citation xml:lang="en">Bispen AV, Zuban' ON, Iagafarova RK. Bolezn' Furn'e i tuberkulez polovykh organov [Fournier disease and genital tuberculosis]. Probl Tuberk. 1999;(6):57-58. (In Russian). PMID: 10715966</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Schnack J, Mittal A, Chang CF. Prostatic Tuberculosis: A Rare Cause of Fournier Gangrene. Chest infections. 2014;145(3S):128A. DOI: 10.1378/chest.1825237</mixed-citation><mixed-citation xml:lang="en">Schnack J, Mittal A, Chang CF. Prostatic Tuberculosis: A Rare Cause of Fournier Gangrene. Chest infections. 2014;145(3S):128A. DOI: 10.1378/chest.1825237</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wetterauer C, Ebbing J, Halla A, Kuehl R, Erb S, Egli A, Schaefer DJ, Seifert HH. A contemporary case series of Fournier's gangrene at a Swiss tertiary care center-can scoring systems accurately predict mortality and morbidity? World J Emerg Surg. 2018;13:25. DOI: 10.1186/s13017-018-0187-0</mixed-citation><mixed-citation xml:lang="en">Wetterauer C, Ebbing J, Halla A, Kuehl R, Erb S, Egli A, Schaefer DJ, Seifert HH. A contemporary case series of Fournier's gangrene at a Swiss tertiary care center-can scoring systems accurately predict mortality and morbidity? World J Emerg Surg. 2018;13:25. DOI: 10.1186/s13017-018-0187-0</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hagedorn JC, Wessells H. A contemporary update on Fournier's gangrene. Nat Rev Urol. 2017;14(4):205-214. DOI: 10.1038/nrurol.2016.243</mixed-citation><mixed-citation xml:lang="en">Hagedorn JC, Wessells H. A contemporary update on Fournier's gangrene. Nat Rev Urol. 2017;14(4):205-214. DOI: 10.1038/nrurol.2016.243</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chernyadyev SA, Ufimtseva MA, Vishnevskaya IF, Bochkarev YM, Ushakov AA, Beresneva TA, Galimzyanov FV, Khodakov VV. Fournier's Gangrene: Literature Review and Clinical Cases. Urol Int. 2018;101(1):91-97. DOI: 10.1159/000490108</mixed-citation><mixed-citation xml:lang="en">Chernyadyev SA, Ufimtseva MA, Vishnevskaya IF, Bochkarev YM, Ushakov AA, Beresneva TA, Galimzyanov FV, Khodakov VV. Fournier's Gangrene: Literature Review and Clinical Cases. Urol Int. 2018;101(1):91-97. DOI: 10.1159/000490108</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Misiakos EP, Bagias G, Patapis P, Sotiropoulos D, Kanavidis P, Machairas A. Current concepts in the management of necrotizing fasciitis. Front Surg. 2014;1:36. DOI: 10.3389/fsurg.2014.00036</mixed-citation><mixed-citation xml:lang="en">Misiakos EP, Bagias G, Patapis P, Sotiropoulos D, Kanavidis P, Machairas A. Current concepts in the management of necrotizing fasciitis. Front Surg. 2014;1:36. DOI: 10.3389/fsurg.2014.00036</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Laor E, Palmer LS, Tolia BM, Reid RE, Winter HI. Outcome prediction in patients with Fournier's gangrene. J Urol. 1995;154(1):89-92. PMID: 7776464</mixed-citation><mixed-citation xml:lang="en">Laor E, Palmer LS, Tolia BM, Reid RE, Winter HI. Outcome prediction in patients with Fournier's gangrene. J Urol. 1995;154(1):89-92. PMID: 7776464</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yilmazlar T, Ozturk E, Ozguc H, Ercan I, Vuruskan H, Oktay B. Fournier's gangrene: an analysis of 80 patients and a novel scoring system. Tech Coloproctol. 2010;14(3):217-223. DOI: 10.1007/s10151-010-0592-1</mixed-citation><mixed-citation xml:lang="en">Yilmazlar T, Ozturk E, Ozguc H, Ercan I, Vuruskan H, Oktay B. Fournier's gangrene: an analysis of 80 patients and a novel scoring system. Tech Coloproctol. 2010;14(3):217-223. DOI: 10.1007/s10151-010-0592-1</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira PC, Reis JC, Amarante JM, Silva ÁC, Pinho CJ, Oliveira IC, da Silva PN. Fournier's gangrene: a review of 43 reconstructive cases. Plast Reconstr Surg. 2007;119(1):175-184. DOI: 10.1097/01.prs.0000244925.80290.57</mixed-citation><mixed-citation xml:lang="en">Ferreira PC, Reis JC, Amarante JM, Silva ÁC, Pinho CJ, Oliveira IC, da Silva PN. Fournier's gangrene: a review of 43 reconstructive cases. Plast Reconstr Surg. 2007;119(1):175-184. DOI: 10.1097/01.prs.0000244925.80290.57</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuura H, Iwasa K. Fournier gangrene. Cleve Clin J Med. 2018;85(9):664-665. DOI: 10.3949/ccjm.85a.18036</mixed-citation><mixed-citation xml:lang="en">Matsuura H, Iwasa K. Fournier gangrene. Cleve Clin J Med. 2018;85(9):664-665. DOI: 10.3949/ccjm.85a.18036</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Eron LJ, Lipsky BA, Low DE, Nathwani D, Tice AD, Volturo GA; Expert panel on managing skin and soft tissue infections. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother. 2003;52 Suppl 1:i3-17. DOI: 10.1093/jac/dkg466</mixed-citation><mixed-citation xml:lang="en">Eron LJ, Lipsky BA, Low DE, Nathwani D, Tice AD, Volturo GA; Expert panel on managing skin and soft tissue infections. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother. 2003;52 Suppl 1:i3-17. DOI: 10.1093/jac/dkg466</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Levenson RB, Singh AK, Novelline RA. Fournier gangrene: role of imaging. Radiographics. 2008;28(2):519-528. DOI: 10.1148/rg.282075048</mixed-citation><mixed-citation xml:lang="en">Levenson RB, Singh AK, Novelline RA. Fournier gangrene: role of imaging. Radiographics. 2008;28(2):519-528. DOI: 10.1148/rg.282075048</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Louro JM, Albano M, Baltazar J, Vaz M, Diogo C, Ramos S, Cabral L. Fournier's Gangrene: 10-Year Experience of a Plastic Surgery and Burns Department at a Tertiary Hospital. Acta Med Port. 2019;32(5):368-374. DOI: 10.20344/amp.11003</mixed-citation><mixed-citation xml:lang="en">Louro JM, Albano M, Baltazar J, Vaz M, Diogo C, Ramos S, Cabral L. Fournier's Gangrene: 10-Year Experience of a Plastic Surgery and Burns Department at a Tertiary Hospital. Acta Med Port. 2019;32(5):368-374. DOI: 10.20344/amp.11003</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Insua-Pereira I, Ferreira PC, Teixeira S, Barreiro D, Silva Á. Fournier's gangrene: a review of reconstructive options. Cent European J Urol. 2020;73(1):74-79. DOI: 10.5173/ceju.2020.0060</mixed-citation><mixed-citation xml:lang="en">Insua-Pereira I, Ferreira PC, Teixeira S, Barreiro D, Silva Á. Fournier's gangrene: a review of reconstructive options. Cent European J Urol. 2020;73(1):74-79. DOI: 10.5173/ceju.2020.0060</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis GD, Majeed M, Olang CA, Patel A, Gorantla VR, Davis N, Gluschitz S. Fournier's Gangrene Diagnosis and Treatment: A Systematic Review. Cureus. 2021;13(10):e18948. DOI: 10.7759/cureus.18948</mixed-citation><mixed-citation xml:lang="en">Lewis GD, Majeed M, Olang CA, Patel A, Gorantla VR, Davis N, Gluschitz S. Fournier's Gangrene Diagnosis and Treatment: A Systematic Review. Cureus. 2021;13(10):e18948. DOI: 10.7759/cureus.18948</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
