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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urovest</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник урологии</journal-title><trans-title-group xml:lang="en"><trans-title>Urology Herald</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2308-6424</issn><publisher><publisher-name>Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2308-6424-2023-11-4-100-107</article-id><article-id custom-type="elpub" pub-id-type="custom">urovest-801</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Многофакторный анализ осложнённой суправезикальной  обструкции у пациентов с мочекаменной болезнью</article-title><trans-title-group xml:lang="en"><trans-title>Complicated supravesical obstruction in patients with urolithiasis: multifactorial analysis of risk factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2061-1522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanov</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мардон Мухаммадикулович Хасанов — д-р философии, заведующий научной лабораторией </p><p> Ташкент</p></bio><bio xml:lang="en"><p>Mardon M. Khasanov — M.D., Ph.D.(Med); Head, Research Laboratory No. 2</p><p>Tashkent</p></bio><email xlink:type="simple">mardon.khasanov.1984@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4123-2695</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуфаттаев</surname><given-names>У. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdufattaev</surname><given-names>U. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Улугбек Авазжонович Абдуфаттаев — заведующий отделением ультразвуковой диагностики </p><p> Ташкент</p></bio><bio xml:lang="en"><p>Ulugbek A. Abdufattaev — M.D.; Head, Ultrasound Diagnostics Division</p><p>Tashkent</p></bio><email xlink:type="simple">abdufattaev@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-1681-5860</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Номанов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nomanov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анвар Абдукаримович Номанов — младший научный сотрудник научной лаборатории №2 </p><p> Ташкент</p></bio><bio xml:lang="en"><p> Anvar A. Nomanov — M.D.; Junior Researcher, Research Laboratory No. 2</p><p>Tashkent</p></bio><email xlink:type="simple">nomanov044@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4352-2111</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухтаров</surname><given-names>Ш. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhtarov</surname><given-names>Sh. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шухрат Турсунович Мухтаров — д-р мед. наук, доцент; директор </p><p> Ташкент</p></bio><bio xml:lang="en"><p>Shukhrat T. Mukhtarov — M.D., Dr.Sc.(Med), Assoc.Prof.(Docent); Director</p><p>Tashkent</p></bio><email xlink:type="simple">msht_doc@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский специализированный научно-практический медицинский центр урологии</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent Republican Specialised Scientific and Practical Medical Centre of Urology</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>26</day><month>12</month><year>2023</year></pub-date><volume>11</volume><issue>4</issue><fpage>100</fpage><lpage>107</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хасанов М.М., Абдуфаттаев У.А., Номанов А.А., Мухтаров Ш.Т., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Хасанов М.М., Абдуфаттаев У.А., Номанов А.А., Мухтаров Ш.Т.</copyright-holder><copyright-holder xml:lang="en">Khasanov M.M., Abdufattaev U.A., Nomanov A.A., Mukhtarov S.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.urovest.ru/jour/article/view/801">https://www.urovest.ru/jour/article/view/801</self-uri><abstract><sec><title>Введение</title><p>Введение. Мочекаменная болезнь (МКБ) — распространённое заболевание, наблюдающееся у значительного числа людей во всем мире. Суправезикальная обструкция (СВО) — явление менее распространённое, но потенциально опасное, возникающее при блокаде мочевыводящих путей над мочевым пузырём, часто приводящее к ухудшению пассажа мочи и требующее в большинстве случаев хирургического вмешательства.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Определить факторы риска осложнённой суправезикальной обструкции у пациентов с мочекаменной болезнью.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено ретроспективное исследование результатов диагностики и лечения пациентов с СВО, страдающих МКБ. С 2017 по 2019 годы в ГУ «РСНПМЦУ» обследованы и пролечены 6 250 больных с СВО. Критерии отбора — пациенты с установленной МКБ и СВО. Критерии исключения — наличие онкологического заболевания и / или специфической инфекции, привёдшей к СВО. После оценки соответствия критериям включения и исключения для исследования были отобраны 1106 пациентов, у которых были изучены факторы риска, привёдшие к осложнённому течению СВО.</p></sec><sec><title>Результаты</title><p>Результаты. Нами были оценены факторы риска развития осложнённой СВО у пациентов с МКБ. Все результаты представлены EXP(B), с 95%-ным доверительным интервалом в квадратных скобках: cложные камни почки — 5,326 [2,247 – 9,296], камни мочеточника — 12,251 [7,256 – 21,226], двусторонняя локализация камней — 7,256 [2,158 – 9,255], длительность заболевания — 4,324 [1,782 – 8,256], наличие инфекции мочевых путей — 19,258 [4,258 – 26,248], лейкоцитоз крови — 15,116 [3,985 – 21,256], высокий уровень креатинина — 10,244 [5,269 – 16,254], высокий уровень глюкозы — 5,226 [3,145 – 11,254].</p></sec><sec><title>Заключение</title><p>Заключение. Результаты исследования позволяют установить, что блокирующие камни почек и мочеточников, вовлечённость в патологический процесс обеих почек, наличие инфекции верхних мочевых путей, низкий клиренс почек, наличие сахарного диабета и длительность заболевания являются значимыми факторами риска осложнённого течения суправезикальной обструкции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Urolithiasis (UL) is a common disease observed in a huge number of people around the world. Supravesical obstruction (SVO) is a less frequent but potentially dangerous phenomenon that occurs when the urinary tract is blocked above the bladder, often resulting in impaired urinary passage and requiring surgery in most cases.</p></sec><sec><title>Objective</title><p>Objective. To determine the risk factors of complicated supravesical obstruction in patients with urolithiasis.</p></sec><sec><title>Materials &amp; methods</title><p>Materials &amp; methods. We have conducted a retrospective study of diagnostic and treatment results of patients with SVO suffering from UL. Inclusion criteria: patients with established UL and SVO. Exclusion criteria: cancer and/or specific infection leading to SVO. From 2017 to 2019, 6250 patients with SVO were screened and treated at our centre. After assessing compliance with the inclusion and exclusion criteria, 1106 patients were selected for the study. We studied the risk factors leading to complicated course of SVO.</p></sec><sec><title>Results</title><p>Results. We evaluated the risk factors for the development of complicated SVO in patients with UL. All results are presented by EXP(B), with a 95% confidence interval in square brackets: complex kidney stones — 5,326 [2,247 – 9,296], ureteral stones — 12,251 [7,256 – 21,226], double-sided stones — 7,256 [2,158 – 9,255], disease length — 4,324 [1,782 – 8,256], urinary tract infection — 19,258 [4,258 – 26,248], blood leukocytosis — 15,116 [3,985 – 21,256], high serum creatinine — 10,244 [5,269 – 16,254], high serum glucose — 5,226 [3,145 – 11,254].</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of the study suggest that blocking renal and ureteral stones, double-side stones, upper urinary tract infection, low creatinine clearance, diabetes mellitus and disease length are significant risk factors for complicated course of SVO.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>мочекаменная болезнь</kwd><kwd>обструкция мочевыводящих путей</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urolithiasis</kwd><kwd>upper urinary tract obstruction</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Scales CD, Jr., Smith AC, Hanley JM, Saigal CS, Urologic Diseases in America P. Prevalence of kidney stones in the United States. Eur Urol. 2012;62(1):160-5. DOI: 10.1016/j.eururo.2012.03.052</mixed-citation><mixed-citation xml:lang="en">Scales CD, Jr., Smith AC, Hanley JM, Saigal CS, Urologic Diseases in America P. 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