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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urovest</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник урологии</journal-title><trans-title-group xml:lang="en"><trans-title>Urology Herald</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2308-6424</issn><publisher><publisher-name>Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2308-6424-2023-11-2-171-180</article-id><article-id custom-type="elpub" pub-id-type="custom">urovest-732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Коралловидный нефролитиаз и плоскоклеточный рак лоханки: клиническое наблюдение и обзор литературных данных</article-title><trans-title-group xml:lang="en"><trans-title>Staghorn stone and squamous cell carcinoma of the renal pelvis: a clinical case and literature review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7558-589X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзитиев</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzitiev</surname><given-names>V. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виталий Казиханович Дзитиев — кандидат медицинских наук; заведующий урологическим отделением, научный сотрудник отдела урологии и андрологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Vitaly K. Dzitiev — M.D., Сand.Sc.(Med); Head, Urology Division, Researcher, Urology and Andrology Unit.</p><p>Moscow</p></bio><email xlink:type="simple">vitdok@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9466-7567</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокин</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokin</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Иванович Сорокин — доктор медицинских наук; профессор кафедры урологии и андрологии факультета фундаментальной медицины, ведущий научный сотрудник отдела урологии и андрологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Nikolay I. Sorokin — M.D., Dr.Sc.(Med), Full Prof.; Prof., Dept. of Urology and Andrology, Faculty of Fundamental Medicine; Leading Researcher, Urology and Andrology Unit, Medical Research and Education Centre.</p><p>Moscow</p></bio><email xlink:type="simple">nisorokin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5649-2193</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синицын</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinitsyn</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валентин Евгеньевич Синицын — доктор медицинских наук, профессор; заведующий кафедрой лучевой диагностики и терапии факультета фундаментальной медицины.</p><p>Москва</p></bio><bio xml:lang="en"><p>Valentin E. Sinitsyn — M.D., Dr.Sc.(Med), Full Prof.; Head, Dept. of Radiology, Faculty of Fundamental Medicine.</p><p>Moscow</p></bio><email xlink:type="simple">vsini@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3355-4547</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нестерова</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesterova</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Юрьевна Нестерова — кандидат медицинских наук; врач-уролог общеклинического отделения, научный сотрудник отдела урологии и андрологии МНОЦ, старший преподаватель кафедры урологии и андрологии факультета фундаментальной медицины.</p><p>Москва</p></bio><bio xml:lang="en"><p>Olga Yu. Nesterova — M.D., Сand.Sc.(Med); Urologist – General Clinical Division, Researcher – Urology and Andrology Unit, Medical Research and Education Centre; Senior Lecturer, Dept. of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University</p><p>Moscow</p></bio><email xlink:type="simple">oy.nesterova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7848-6707</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Владимировна Данилова — кандидат медицинских наук; старший научный сотрудник отдела клинической патологии МНОЦ, ассистент кафедры физиологии и общей патологии факультета фундаментальной медицины.</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalya V. Danilova — M.D., Cand.Sc.(Med); Senior Researcher, Clinical Pathology Unit, Medical Research and Educational Centre; Assist.Prof., Dept. of Physiology and General Pathology, Faculty of Fundamental Medicine.</p><p>Moscow</p></bio><email xlink:type="simple">natalyadanilova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4014-2359</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бадмаева</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Badmaeva</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Михайловна Бадмаева — ординатор кафедры урологии и андрологии факультета фундаментальной медицины.</p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina M. Badmaeva — Resident, Dept. of Urology and Andrology, Faculty of Fundamental Medicine.</p><p>Moscow</p></bio><email xlink:type="simple">kbadmaeva98@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4518-634X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стригунов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Strigunov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Алексеевич Стригунов — врач уролог общеклинического отделения, стажёр-исследователь отдела урологии и андрологии МНОЦ, аспирант кафедры урологии и андрологии факультета фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова»</p><p>Москва</p></bio><bio xml:lang="en"><p>Andrey A. Strigunov — M.D.; Urologist – General Clinical Division, Trainee Researcher  – Urology and Andrology Unit, Medical Research and Education Centre; Postgrad. Student, Dept. of Urology and Andrology, Faculty of Fundamental Medicine.</p><p>Moscow</p></bio><email xlink:type="simple">an-strigunov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7732-4093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цурская</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsurskaya</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дарья Дмитриевна Цурская — врач-рентгенолог МНОЦ.</p><p>Москва</p></bio><bio xml:lang="en"><p>Daria D. Tsurskaya — M.D.; Radiologist, Medical Research and Educational Centre.</p><p>Moscow</p></bio><email xlink:type="simple">dashnom03@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4251-7545</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камалов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamalov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Армаис Альбертович Камалов — доктор медицинских наук, профессор, академик РАН; директор МНОЦ, заведующий кафедрой урологии и андрологии факультета фундаментальной медицины.</p><p>Москва</p></bio><bio xml:lang="en"><p>Armais A. Kamalov — M.D., Dr.Sc.(Med), Full Prof., Acad. of the RAS; Headmaster, Medical Research and Educational Centre; Head, Dept. of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University</p><p>Moscow</p></bio><email xlink:type="simple">armais.kamalov@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный университет им. М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University (Lomonosov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2023</year></pub-date><volume>11</volume><issue>2</issue><fpage>171</fpage><lpage>180</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дзитиев В.К., Сорокин Н.И., Синицын В.Е., Нестерова О.Ю., Данилова Н.В., Бадмаева Е.М., Стригунов А.А., Цурская Д.Д., Камалов А.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Дзитиев В.К., Сорокин Н.И., Синицын В.Е., Нестерова О.Ю., Данилова Н.В., Бадмаева Е.М., Стригунов А.А., Цурская Д.Д., Камалов А.А.</copyright-holder><copyright-holder xml:lang="en">Dzitiev V.K., Sorokin N.I., Sinitsyn V.E., Nesterova O.Y., Danilova N.V., Badmaeva E.M., Strigunov A.A., Tsurskaya D.D., Kamalov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.urovest.ru/jour/article/view/732">https://www.urovest.ru/jour/article/view/732</self-uri><abstract><p>Плоскоклеточный рак почечной лоханки является крайне редким новообразованием, частота встречаемости которого не превышает 1% от всех новообразований данной локализации. В общей популяции до 90% всех новообразований почечной лоханки представлено уротелиальной карциномой, в то время как от 0,7% до 7% случаев приходится на плоскоклеточный рак. Камни чашечно-лоханочной системы встречаются у 14 – 50% пациентов с плоскоклеточным раком лоханки. В качестве возможного этиопатогенетического механизма рассматривается хроническое воспаление на фоне камня, приводящее к плоскоклеточной метаплазии уротелия с последующим ороговением и малигнизацией. Клиническая манифестация плоскоклеточного рака лоханки, как правило, неспецифическая и связана, в первую очередь, с проявлениями мочекаменной болезни. Плоскоклеточный рак лоханки отличается высокой агрессивностью, нечувствительностью к химио- и лучевой терапии и, соответственно, неблагоприятным прогнозом. Выживаемость большинства пациентов составляет менее 1 года с момента постановки диагноза, в то время как 5-летняя выживаемость не превышает 10%. Мы представляем собственное клиническое наблюдение случая пациента с коралловидным камнем почки и плоскоклеточным раком почечной лоханки.</p></abstract><trans-abstract xml:lang="en"><p>Squamous cell carcinoma of the renal pelvis is a rare neoplasm. The incidence does not exceed 1% of all neoplasms of this localization. In the general population, up to 90% of all neoplasms of the renal pelvis are represented by urothelial carcinoma, while from 0.7% to 7.0% of cases are squamous cell carcinoma. Stones of the renal collecting system are found in 14 – 50% of patients with squamous cell carcinoma of the pelvis. As a possible etiopathogenetic mechanism, chronic inflammation on the background of a stone is considered, leading to squamous urothelial metaplasia with subsequent keratinization and malignization. Clinical manifestation of squamous cell carcinoma of the renal pelvis is nonspecific and is primarily associated with manifestations of urolithiasis. Squamous cell carcinoma of the renal pelvis is characterised by high aggressiveness, insensitivity to chemotherapy and radiation therapy, and consequently an unfavourable prognosis. The survival rate of most patients is less than one year from the diagnosis, while the 5-year survival rate does not exceed 10%. We present our own clinical case of a patient with a staghorn stone and squamous cell carcinoma of the renal pelvis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>плоскоклеточный рак лоханки</kwd><kwd>коралловидный нефролитиаз</kwd><kwd>мочекаменная болезнь</kwd><kwd>нефрэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>squamous cell carcinoma</kwd><kwd>renal pelvis</kwd><kwd>staghorn stone</kwd><kwd>urolithiasis</kwd><kwd>nephrectomy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The study was not sponsored</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kalayci OT, Bozdag Z, Sonmezgoz F, Sahin N. 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