urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2022-10-2-99-108urovest-551Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS ARTICLEФакторы риска, антибиотикопрофилактика и лечение инфекции мочевых путей при трансуретральной хирургии гиперплазии простатыRisk factors, antibiotic prophylaxis, and treatment of urinary tract infection in transurethral surgery for benign prostatic hyperplasiahttps://orcid.org/0000-0002-1710-0169КоганМ. И.KoganM. I.

Михаил Иосифович Коган – доктор медицинских наук, профессор, заслуженный деятель науки РФ; заведующий кафедрой урологии и репродуктивного здоровья человека (с курсом детской урологии-андрологии)

344022, г. Ростов-на-Дону, пер. Нахичеванский, д. 29

Mikhail I. Kogan – M.D., Dr.Sc.(Med), Full Prof., Honored Scientist of the Russian Federation; Head, Dept. of Urology and Human Reproductive Health (with Pediatric Urology and Andrology Course) 

29 Nakhichevanskiy Ln., Rostov-on-Don, 344022

dept_kogan@mail.ruhttps://orcid.org/0000-0002-0937-4573НабокаЮ. Л.NabokaYu. L.

Юлия Лазаревна Набока – доктор медицинских наук, профессор; заведующая кафедрой микробиологии и вирусологии №1

344022, г. Ростов-на-Дону, пер. Нахичеванский, д. 29

Yulia L. Naboka – M.D., Dr.Sc. (Med), Full Prof., Head, Dept. of Microbiology and Virology №1 

29 Nakhichevanskiy Ln., Rostov-on-Don, 344022

nula33@mail.ruhttps://orcid.org/0000-0002-9772-937XИвановС. Н.IvanovS. N.

Сергей Никитич Иванов – ординатор кафедры урологии и репродуктивного здоровья человека (с курсом детской урологии-андрологии)

344022, г. Ростов-на-Дону, пер. Нахичеванский, д. 29

Sergey N. Ivanov – Resident, Dept. of Urology and Human Reproductive Health (with Pediatric Urology and Andrology Course) 

29 Nakhichevanskiy Ln., Rostov-on-Don, 344022

ivanovsergey19@gmail.comФБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation20222606202210299108Copyright © Коган М.И., Набока Ю.Л., Иванов С.Н., 20222022Коган М.И., Набока Ю.Л., Иванов С.Н.Kogan M.I., Naboka Y.L., Ivanov S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/551

Обсуждение факторов риска инфекционных осложнений в общей популяции больных, перенесших трансуретральную резекцию простаты, вопросов антибиотикопрофилактики и терапии ведётся на протяжении десятилетий. Сегодня представляется малообсуждаемой проблема манифестации бактериурии в клинические инфекционные процессы в различные сроки послеоперационного периода, а также факторы проникновения бактериальных агентов с их дальнейшей субклинической циркуляцией в мочевой и половой системах. Недостаточная изученность данных вопросов подтверждается небольшим числом исследований, охватывающих в основном электрохирургические моно- и биполярные технологии как наиболее распространённые и изученные за долгий срок своего существования. Данные обзор поднимает проблему недостаточной изученности клинической структуры инфекций при трансуретральной хирургии, оценке их факторов риска, режимов антибиотикопрофилактики и терапии.

Discussion of risk factors for infectious complications in the general population of patients undergoing transurethral resection of the prostate, antibiotic prophylaxis and therapy has been going on for decades. Up to date, the problem of the manifestation of bacteriuria in clinical infectious processes at various periods, as well as the factors of the introduction of bacterial agents with their further subclinical circulation in the urinary and reproductive systems, seems to be little discussed. The insufficient knowledge of these issues is confirmed by a small number of studies covering mainly electrosurgical mono and bipolar technologies as the most common and studied over a long period of their existence. This review raises the problem of insufficient knowledge of the clinical structure of infections during transurethral surgery, assessment of their risk factors, antibiotic prophylaxis regimens and therapy.

гиперплазия простатытрансуретральная хирургияинфекции мочевых путейосложнениябактериурияbenign prostatic hyperplasiatransurethral surgeryurinary tract infectionscomplicationsbacteriuriaReferencesGrabe M. Antimicrobial agents in transurethral prostatic resection. J Urol. 1987;138(2):245-52. DOI: 10.1016/s0022-5347(17)43109-0.Grabe M. Antimicrobial agents in transurethral prostatic resection. J Urol. 1987;138(2):245-52. DOI: 10.1016/s0022-5347(17)43109-0.Wagenlehner FM, Wagenlehner C, Schinzel S, Naber KG. Prospective, randomized, multicentric, open, comparative study on the efficacy of a prophylactic single dose of 500 mg levofloxacin versus 1920 mg trimethoprim/ sulfamethoxazole versus a control group in patients undergoing TUR of the prostate. Eur Urol. 2005;47(4):549-56. DOI: 10.1016/j.eururo.2005.01.004.Wagenlehner FM, Wagenlehner C, Schinzel S, Naber KG. Prospective, randomized, multicentric, open, comparative study on the efficacy of a prophylactic single dose of 500 mg levofloxacin versus 1920 mg trimethoprim/ sulfamethoxazole versus a control group in patients undergoing TUR of the prostate. Eur Urol. 2005;47(4):549-56. DOI: 10.1016/j.eururo.2005.01.004.Girou E, Rioux C, Brun-Buisson C, Lobel B. Infection Committee of the French Association of Urology. The postoperative bacteriuria score: a new way to predict nosocomial infection after prostate surgery. Infect Control Hosp Epidemiol. 2006;27(8):847-54. DOI: 10.1086/506398.Girou E, Rioux C, Brun-Buisson C, Lobel B. Infection Committee of the French Association of Urology. The postoperative bacteriuria score: a new way to predict nosocomial infection after prostate surgery. Infect Control Hosp Epidemiol. 2006;27(8):847-54. DOI: 10.1086/506398.Osman T, ElSaeed KO, Youssef HA, Shabayek M, Emam A, Hussein MS. Evaluation of the risk factors associated with the development of post-transurethral resection of the prostate persistent bacteriuria. Arab J Urol. 2017;15(3):260- 6. DOI: 10.1016/j.aju.2017.05.004.Osman T, ElSaeed KO, Youssef HA, Shabayek M, Emam A, Hussein MS. Evaluation of the risk factors associated with the development of post-transurethral resection of the prostate persistent bacteriuria. Arab J Urol. 2017;15(3):260- 6. DOI: 10.1016/j.aju.2017.05.004.Colau A, Lucet JC, Rufat P, Botto H, Benoit G, Jardin A. Incidence and risk factors of bacteriuria after transurethral resection of the prostate. Eur Urol. 2001;39(3):272-6. DOI: 10.1159/000052452.Colau A, Lucet JC, Rufat P, Botto H, Benoit G, Jardin A. Incidence and risk factors of bacteriuria after transurethral resection of the prostate. Eur Urol. 2001;39(3):272-6. DOI: 10.1159/000052452.Huang X, Shi HB, Wang XH, Zhang XJ, Chen B, Men XW, Yu ZY. Bacteriuria after bipolar transurethral resection of the prostate: risk factors and correlation with leukocyturia. Urology. 2011;77(5):1183-7. DOI: 10.1016/j.urology.2010.08.013.Huang X, Shi HB, Wang XH, Zhang XJ, Chen B, Men XW, Yu ZY. Bacteriuria after bipolar transurethral resection of the prostate: risk factors and correlation with leukocyturia. Urology. 2011;77(5):1183-7. DOI: 10.1016/j.urology.2010.08.013.Evan Botti F, Oleszak M, Likhtshteyn A, Maryniak M. Rahman Infective Endocarditis Following TURP Procedures: A Case Report and Review of Literature. American Journal of Medical Case Reports. 2020;8(10):370-3. DOI: 10.12691/ajmcr-8-10-14.Evan Botti F, Oleszak M, Likhtshteyn A, Maryniak M. Rahman Infective Endocarditis Following TURP Procedures: A Case Report and Review of Literature. American Journal of Medical Case Reports. 2020;8(10):370-3. DOI: 10.12691/ajmcr-8-10-14.Schneidewind L, Kranz J, Schlager D. Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P. Cent European J Urol. 2017;70(1):112- 7. DOI: 10.5173/ceju.2017.941.Schneidewind L, Kranz J, Schlager D. Mulitcenter study on antibiotic prophylaxis, infectious complications and risk assessment in TUR-P. Cent European J Urol. 2017;70(1):112- 7. DOI: 10.5173/ceju.2017.941.El Basri A, Petrolekas A, Cariou G, Doublet JD, Hoznek A, Bruyere F. Clinical Significance of Routine Urinary Bacterial Culture After Transurethral Surgery: Results of a Prospective Multicenter Study. Urology. 2011;79(3):564-9. DOI: 10.1016/j.urology.2011.11.018.El Basri A, Petrolekas A, Cariou G, Doublet JD, Hoznek A, Bruyere F. Clinical Significance of Routine Urinary Bacterial Culture After Transurethral Surgery: Results of a Prospective Multicenter Study. Urology. 2011;79(3):564-9. DOI: 10.1016/j.urology.2011.11.018.Guo RQ, Yu W, Meng Y. Correlation of benign prostatic obstruction-related complications with clinical outcomes in patients after transurethral resection of the prostate. The Kaohsiung Journal of Medical Sciences. 2017;33(3):144-151. DOI: 10.1016/j.kjms.2017.01.002.Guo RQ, Yu W, Meng Y. Correlation of benign prostatic obstruction-related complications with clinical outcomes in patients after transurethral resection of the prostate. The Kaohsiung Journal of Medical Sciences. 2017;33(3):144-151. DOI: 10.1016/j.kjms.2017.01.002.Rassweiler J, Teber D, Kuntz R, Hofmann R. Complications of transurethral resection of the prostate (TURP)– incidence, management, and prevention. Eur Urol. 2006;50(5):969-79; discussion 980. DOI: 10.1016/j.eururo.2005.12.042.Rassweiler J, Teber D, Kuntz R, Hofmann R. Complications of transurethral resection of the prostate (TURP)– incidence, management, and prevention. Eur Urol. 2006;50(5):969-79; discussion 980. DOI: 10.1016/j.eururo.2005.12.042.Vivien A, Lazard T, Rauss A, Laisné MJ, Bonnet F. Infection after transurethral resection of the prostate: variation among centers and correlation with a long-lasting surgical procedure. Association pour la Recherche en Anesthésie-Réanimation. Eur Urol. 1998;33(4):365-9. DOI: 10.1159/000019617.Vivien A, Lazard T, Rauss A, Laisné MJ, Bonnet F. Infection after transurethral resection of the prostate: variation among centers and correlation with a long-lasting surgical procedure. Association pour la Recherche en Anesthésie-Réanimation. Eur Urol. 1998;33(4):365-9. DOI: 10.1159/000019617.Kikuchi M, Kameyama K, Yasuda M, Yokoi S, Deguchi T, Miwa K. Postoperative infectious complications in patients undergoing holmium laser enucleation of the prostate: Risk factors and microbiological analysis. Int J Urol. 2016;23(9):791-6. DOI: 10.1111/iju.13139.Kikuchi M, Kameyama K, Yasuda M, Yokoi S, Deguchi T, Miwa K. Postoperative infectious complications in patients undergoing holmium laser enucleation of the prostate: Risk factors and microbiological analysis. Int J Urol. 2016;23(9):791-6. DOI: 10.1111/iju.13139.Hwang EC, Yu SH, Kim JB, Jung SI, Kang TW, Kwon DD, Park K. Risk Factors of Infectious Complications after Transurethral Prostate Surgery in Patients with Preoperative Sterile Urine. The Korean Journal of Urogenital Tract Infection and Inflammation. 2013;8(1):27. DOI: 10.14777/kjutii.2013.8.1.27.Hwang EC, Yu SH, Kim JB, Jung SI, Kang TW, Kwon DD, Park K. Risk Factors of Infectious Complications after Transurethral Prostate Surgery in Patients with Preoperative Sterile Urine. The Korean Journal of Urogenital Tract Infection and Inflammation. 2013;8(1):27. DOI: 10.14777/kjutii.2013.8.1.27.Peterson MD, Matlaga BR, Kim SC, Kuo RL, Soergel TM, Watkins SL, Lingeman JE. Holmium laser enucleation of the prostate for men with urinary retention. J Urol. 2005;174(3):998-1001; discussion 1001. DOI: 10.1097/01.ju.0000170230.26743.e4.Peterson MD, Matlaga BR, Kim SC, Kuo RL, Soergel TM, Watkins SL, Lingeman JE. Holmium laser enucleation of the prostate for men with urinary retention. J Urol. 2005;174(3):998-1001; discussion 1001. DOI: 10.1097/01.ju.0000170230.26743.e4.Netsch C, Tiburtius C, Bach T, Knipper S, Gross AJ. Association of Prostate Size and Perioperative Morbidity in Thulium: yAG Vapoenucleation of the Prostate. Urologia Internationalis. 2014;93(1):22-8. DOI: 10.1159/000355105.Netsch C, Tiburtius C, Bach T, Knipper S, Gross AJ. Association of Prostate Size and Perioperative Morbidity in Thulium: yAG Vapoenucleation of the Prostate. Urologia Internationalis. 2014;93(1):22-8. DOI: 10.1159/000355105.Sun Q, Guo W, Cui D, Wang X, Ruan y, Zhao F, Xia S, Han B, Jing Y. Thulium laser enucleation versus thulium laser resection of the prostate for prevention of bladder neck contracture in a small prostate: a prospective randomized trial. World J Urol. 2019;37(5):853-859. DOI: 10.1007/s00345-018-2463-8.Sun Q, Guo W, Cui D, Wang X, Ruan y, Zhao F, Xia S, Han B, Jing Y. Thulium laser enucleation versus thulium laser resection of the prostate for prevention of bladder neck contracture in a small prostate: a prospective randomized trial. World J Urol. 2019;37(5):853-859. DOI: 10.1007/s00345-018-2463-8.Gross AJ, Netsch C, Knipper S, Hölzel J, Bach T. Complications and Early Postoperative Outcome in 1080 Patients After Thulium Vapoenucleation of the Prostate: Results at a Single Institution. European Urology. 2013;63(5):859-67. DOI: 10.1016/j.eururo.2012.11.048.Gross AJ, Netsch C, Knipper S, Hölzel J, Bach T. Complications and Early Postoperative Outcome in 1080 Patients After Thulium Vapoenucleation of the Prostate: Results at a Single Institution. European Urology. 2013;63(5):859-67. DOI: 10.1016/j.eururo.2012.11.048.Pokrzywa CJ, Papageorge CM, Kennedy GD. Preoperative urinary tract infection increases postoperative morbidity. J Surg Res. 2016;205(1):213-20. DOI: 10.1016/j.jss.2016.06.025.Pokrzywa CJ, Papageorge CM, Kennedy GD. Preoperative urinary tract infection increases postoperative morbidity. J Surg Res. 2016;205(1):213-20. DOI: 10.1016/j.jss.2016.06.025.Berry A, Barratt A. Prophylactic antibiotic use in transurethral prostatic resection: a meta-analysis. J Urol. 2002;167(2 Pt 1):571-7. PMID: 11792921.Berry A, Barratt A. Prophylactic antibiotic use in transurethral prostatic resection: a meta-analysis. J Urol. 2002;167(2 Pt 1):571-7. PMID: 11792921.Rodrigues P, Hering F, Meller A, Campagnari JC, D’Império M. A randomized and prospective study on the value of antibiotic prophylaxis administration in transurethral resection of the prostate. Sao Paulo Med J. 2004;122(1):4-7. DOI: 10.1590/s1516-31802004000100002.Rodrigues P, Hering F, Meller A, Campagnari JC, D’Império M. A randomized and prospective study on the value of antibiotic prophylaxis administration in transurethral resection of the prostate. Sao Paulo Med J. 2004;122(1):4-7. DOI: 10.1590/s1516-31802004000100002.Qiang W, Jianchen W, MacDonald R, Monga M, Wilt TJ. Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100,000 bacteria per ml: a systematic review. J Urol. 2005;173(4):1175-81. DOI: 10.1097/01.ju.0000149676.15561.cb.Qiang W, Jianchen W, MacDonald R, Monga M, Wilt TJ. Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100,000 bacteria per ml: a systematic review. J Urol. 2005;173(4):1175-81. DOI: 10.1097/01.ju.0000149676.15561.cb.May A, Broggi E, Lorphelin H, Tabchouri N, Giretti G, Pereira H, Bruyere F. Comparison of the risk of postoperative infection between transurethral vaporesection and transurethral resection of the prostate. Lasers Surg Med. 2014;46(5):405-11. DOI: 10.1002/lsm.22240.May A, Broggi E, Lorphelin H, Tabchouri N, Giretti G, Pereira H, Bruyere F. Comparison of the risk of postoperative infection between transurethral vaporesection and transurethral resection of the prostate. Lasers Surg Med. 2014;46(5):405-11. DOI: 10.1002/lsm.22240.Mohee AR, West R, Baig W, Eardley I, Sandoe JA. A casecontrol study: are urological procedures risk factors for the development of infective endocarditis? BJU Int. 2014;114(1):118-24. DOI: 10.1111/bju.12550.Mohee AR, West R, Baig W, Eardley I, Sandoe JA. A casecontrol study: are urological procedures risk factors for the development of infective endocarditis? BJU Int. 2014;114(1):118-24. DOI: 10.1111/bju.12550.Yuan R, Boyu Y, Fujun Z, Chengyi J, Yifeng J, Xiaohai W, Di C, Shujie X, Bangmin H. Transurethral thulium laser enucleation versus resection of the prostate for treating benign prostatic hyperplasia: a retrospective study. Lasers Med Sci. 2019;34(2):329-334. DOI: 10.1007/s10103-018-2597-3.Yuan R, Boyu Y, Fujun Z, Chengyi J, Yifeng J, Xiaohai W, Di C, Shujie X, Bangmin H. Transurethral thulium laser enucleation versus resection of the prostate for treating benign prostatic hyperplasia: a retrospective study. Lasers Med Sci. 2019;34(2):329-334. DOI: 10.1007/s10103-018-2597-3.EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3.EAU Guidelines. Edn. presented at the EAU Annual Congress Amsterdam 2020. ISBN 978-94-92671-07-3.Cai T, Verze P, Palmieri A, Gacci M, Lanzafame P, Malossini G, Johansen TEB. Is Preoperative Assessment and Treatment of Asymptomatic Bacteriuria Necessary for Reducing the Risk of Postoperative Symptomatic Urinary Tract Infections After Urologic Surgical Procedures? Urology. 2017;99:100-105. DOI: 10.1016/j.urology.2016.10.016.Cai T, Verze P, Palmieri A, Gacci M, Lanzafame P, Malossini G, Johansen TEB. Is Preoperative Assessment and Treatment of Asymptomatic Bacteriuria Necessary for Reducing the Risk of Postoperative Symptomatic Urinary Tract Infections After Urologic Surgical Procedures? Urology. 2017;99:100-105. DOI: 10.1016/j.urology.2016.10.016.Moussa Y, Moussa M, Chakra MA. Enterococcal prosthetic valve endocarditis secondary to transurethral prostatic resection. IDCases. 2020;19:e00708. DOI: 10.1016/j.idcr.2020. e00708.Moussa Y, Moussa M, Chakra MA. Enterococcal prosthetic valve endocarditis secondary to transurethral prostatic resection. IDCases. 2020;19:e00708. DOI: 10.1016/j.idcr.2020. e00708.Matlaga BR, Kim SC, Kuo RL, Watkins SL, Lingeman JE. Holmium laser enucleation of the prostate for prostates of >125 mL. BJU International, 2006;97(1):81-84. DOI: 10.1111/j.1464-410x.2006.05898.x.Matlaga BR, Kim SC, Kuo RL, Watkins SL, Lingeman JE. Holmium laser enucleation of the prostate for prostates of >125 mL. BJU International, 2006;97(1):81-84. DOI: 10.1111/j.1464-410x.2006.05898.x.Naboka YL, Mavzyiutov AR, Kogan MI, Gudima IA, Ivanov SN, Naber KG. Does Escherichia coli have pathogenic potential at a low level of bacteriuria in recurrent, uncomplicated urinary tract infection? Int J Antimicrob Agents. 2020;56(1):105983. DOI: 10.1016/j.ijantimicag.2020.105983.Naboka YL, Mavzyiutov AR, Kogan MI, Gudima IA, Ivanov SN, Naber KG. Does Escherichia coli have pathogenic potential at a low level of bacteriuria in recurrent, uncomplicated urinary tract infection? Int J Antimicrob Agents. 2020;56(1):105983. DOI: 10.1016/j.ijantimicag.2020.105983.

The authors declare that there are no conflicts of interest present.