References

urovest

Вестник урологии

Urology Herald

2308-6424

Rostov State Medical University

10.21886/2308-6424-2013-0-2-43-51

urovest-46

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

REVIEWS ARTICLE

МЕХАНИЗМЫ ПОВРЕЖДЕНИЯ ПОЧЕЧНОЙ ПАРЕНХИМЫ ПРИ РЕФЛЮКС-НЕФРОПАТИИ

MECHANISMS OF RENAL SCARING FROM REFLUX-NEPHROPATHY

Батюшин

М. М.

Batyushin

M. M.

batjushin-m@rambler.ru

Кафедра внутренних болезней с основами физиотерапии №2, Проблемная научная лаборатория экспериментальной нефрологии ГБОУ ВПО РостГМУ Минздрава России, г.Ростов-на-Дону ФГАОУ ВПО «Южный федеральный университет», Научно-исследовательский институт биологииРоссияDepartment of Internal Disease with Physiotherapy №2, Problematic Science Laboratory of Experimental Nephrology Rostov State Medical University, Rostov-on-Don South Federal University, Science Institution of BiologyRussian Federation

2013

20062013

024351

2013

Батюшин М.М.

Batyushin M.M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.urovest.ru/jour/article/view/46

В статье представлены пути патогенеза повреждения почечной ткани в результате везико-уретерального рефлюкса. Автором показана роль макрофагов и тканевых моноци- тов в процессе воспалительного ремоделирования интерстициальной почечной ткани. Клеточные сигналы, воздействуя на интерстициальную ткань, активизируют пролифи- рацию фибробластов и приводят к увеличению интерстициального объема. Цитокины, такие как моноцитарный хемотаксический пептид-1, эпидермальный фактор роста, макрофагальный колониестимулирующий фактор, трансформирующий фактор роста β играют важную роль в процессах повреждения и перестройки почечной ткани. Инфекции мочевых путей приводят к выраженным медуллярным почечным повреждениям путем воздействия токсинов и индуктивных эндогенных цитокинов.

There is presentation of paths of the pathogenesis of renal scaring from vesico-ureteral reflux at this article. Author demonstrated the role of macrophage and tissue monocyte in process of the inflammatory remodeling of interstitial renal tissue. Different cell signals affects interstitial tissue and activates fibroblast ploliferation and interstitial volume increasing. Cytokines such us monocyte chemotactic peptide-1, epidermal growth factor, macrophage colony stimulating factor, transforming growth factor-β1plays important role within process renal scaring and remodeling. Urinary tract infection causes expressed medullar renal scaring by toxins and inductive endogenic cytokines.

везико-уретеральный рефлюксрефлюкс-нефропатияцитокиныповреждение почечной тканиинфекция мочевых путей

vesico-ureteral refluxreflux-nephropathycytokinesrenal scaringurinary tract infection

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The authors declare that there are no conflicts of interest present.