urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2021-9-1-95-104urovest-419Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS ARTICLEСТАТЬЯ ОТОЗВАНА: Структурные нарушения хроматина сперматозоидов. Патофизиологические аспекты. Клиническая значимостьRETRACTED: Structural disorders of the sperm chromatin. Pathophysiological aspects. Clinical relevancehttps://orcid.org/0000-0001-9355-2872КоршуновМ. Н.KorshunovM. N.

Максим Николаевич Коршунов — кандидат медицинских наук; доцент кафедры урологии.

121359, Москва, ул. Маршала Тимошенко, д. 19, стр. 1А; тел.: +7 (905) 749-64-57

Maxim N. Korshunov — M.D., Cand.Sc.(M); Assoc. Prof. (Docent), Dept. of Urology, Central State Medical Academy.

121359, Moscow, 19 bldg. 1A Marshal Tymoshenko st. ; tel.: +7 (905) 749 64-57

m_korshunov@bk.ruhttps://orcid.org/0000-0003-1492-934XКоршуноваЕ. С.KorshunovaE. S.

Екатерина Сергеевна Коршунова — кандидат медицинских наук; доцент кафедры урологии ФГБУ ДПО «ЦГМА» УД Президента РФ; врач ФГБНУ НЦН; врач ФГБОУ ВО МГМСУ им. А.И. Евдокимова Минздрава России.

121359, Москва, ул. Маршала Тимошенко, д. 19, стр. 1А; 125367, Москва, Волоколамское шоссе, д. 80; 127473, Москва, ул. Делегатская, д. 20, стр. 1

Ekaterina S. Korshunova — M.D., Cand.Sc.(M); Assoc. Prof. (Docent), Central Medical Academy Administration of the President of Russian Federation; Physician, Research Center of Neurology; Physician, A.I. Yevdokimov MSUMD.

121359, Moscow, 19 bldg. 1A Marshal Tymoshenko st.; 125367, Moscow, 80 Volokolamskoe hwy; 127473, Moscow, 20 bldg. 1 Delegatskaya st.

e_korshunova@mail.ruhttps://orcid.org/0000-0003-1050-6198КызласовП. С.KyzlasovP. S.

Павел Сергеевич Кызласов — доктор медицинских наук; профессор кафедры урологии и андрологии.

123098, Москва, ул. Маршала Новикова, д. 23

PavelS. Kyzlasov — M.D., Dr.Sc.(M); Prof., Dept. of Urology and Andrology.

123098, Moscow, 23 Marshal Novikov st.

dr.kyzlasov@mail.ruhttps://orcid.org/0000-0003-4266-2830КоршуновД. М.KorshunovD. M.

Данила Максимович Коршунов — студент.

127473, Москва, ул. Делегатская, д. 20, стр. 1; тел.: +7 (905) 749-64-57

Danila M. Korshunov — Student.

127473, Moscow, 20 bldg. 1 Delegatskaya st.

korshunovdanila2001@mail.ruhttps://orcid.org/0000-0002-3797-7160ДаренковС. П.DarenkovS. P.

Сергей Петрович Даренков —доктор медицинских наук, профессор; заведующий кафедрой урологии.

121359, Москва, ул. Маршала Тимошенко, д. 19, стр. 1А

Sergey P. Darenkov — M.D., Dr.Sc.(M); Full Prof.; Head, Dept. of Urology.

121359, Moscow, 19 bldg. 1A Marshal Tymoshenko st.

darenkov@list.ruФГБУ ДПО Центральная государственная медицинская академия Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy, The Administrative Directorate of the President of the Russian FederationRussian FederationФГБУ ДПО Центральная государственная медицинская академия Управления делами Президента Российской Федерации ФГБНУ Научный центр неврологии; ФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РоссииРоссияCentral State Medical Academy, The Administrative Directorate of the President of the Russian Federation; Research Center of Neurology; A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian FederationФГБУ Государственный научный центр Российской Федерации — Федеральный медицинский биофизический центр им. А.И. Бурназяна ФМБА РоссииРоссияState Research Center of the Russian Federation - A. I. Burnazyan Federal Medical Biophysical CenterRussian FederationФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РоссииРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation2021160320219195104Copyright © Коршунов М.Н., Коршунова Е.С., Кызласов П.С., Коршунов Д.М., Даренков С.П., 20212021Коршунов М.Н., Коршунова Е.С., Кызласов П.С., Коршунов Д.М., Даренков С.П.Korshunov M.N., Korshunova E.S., Kyzlasov P.S., Korshunov D.M., Darenkov S.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/419

СТАТЬЯ ОТОЗВАНА

В обзоре приведен анализ отечественных и зарубежных литературных источников по изучению структуры хроматина сперматозоидов. Описаны патогенетические пути формирования ДНК-фрагментации гамет. Представлены данные о взаимосвязи между нарушениями целостности генома сперматозоидов c частотой наступления беременности и родов при лечении методами вспомогательных репродуктивных технологий, рисками привычных потерь беременности. Оценена диагностическая значимость фрагментации ДНК сперматозоидов при мужском факторе бесплодия.

RETRACTED ARTICLE

The review provides an analysis of domestic and foreign sources devoted to the study of the sperm chromatin structure. The pathogenetic pathways of the sperm DNA fragmentation formation are described. The relationship between sperm DNA damage in pregnancy, live birth rate and the recurrent pregnancy losses in the assisted reproductive technique are presented. The prognostic determination's value of the sperm DNA fragmentation in male infertility cases is noted.

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The authors declare that there are no conflicts of interest present.