urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2020-8-2-67-77urovest-332Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS ARTICLEАутологичная плазма обогащённая тромбоцитами: что это и для чего?Platelet-rich autologous plasma: what is it and for what?https://orcid.org/0000-0001-8335-2578МедведевВ. Л.MedvedevV. L.

Владимир Леонидович Медведев ‒ д.м.н., профессор; заведующий кафедрой урологии 

профессор кафедры урологии и репродуктивного здоровья человека (с курсом детской урологии-андрологии)

заместитель главного врача по урологии, руководитель уронефрологического центра

Vladimir L. Medvedev – M.D., Dr.Sc.(M), Full Prof.; Head, Dept. of Urology, Kuban State Medical University; Prof., Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology course)

Head, Urology & Nephrology Center and Urology

Division No. 2, Deputy Chief Medical Officer for the Urological Service

medvedev_vl@mail.ruhttps://orcid.org/0000-0002-1710-0169КоганМ. И.KoganM. I.

Михаил Иосифович Коган – Заслуженный деятель науки РФ, д.м.н., профессор; заведующий кафедрой урологии и репродуктивного здоровья человека (с курсом детской урологии-андрологии)

Mikhail I. Kogan – Honored Scientist of Russian Federation, M.D., Dr.Sc.(M), Full Prof.; Head, Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology course)

dept_kogan@mail.ruhttps://orcid.org/0000-0003-3724-2794МихайловИ. В.MihailovI. V.

Игорь Валерьевич Михайлов ‒ д.м.н., профессор; профессор кафедры урологии

Igor V. Mihailov – M.D., Dr.Sc.(M), Full Prof.; Prof., Dept. of Urology

miv67@yandex.ruhttps://orcid.org/0000-0001-6657-1496ЛепетуновС. Н.LepetunovS. N.

Сергей Николаевич Лепетунов – ассистент кафедры урологии 

врач-уролог 

тел.: +7 (918) 414-64-62

Sergey N. Lepetunov – M.D.; Assist., Dept. of Urology,

Urologist, Urology Division No. 2,

lepetunov@gmail.comФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница №1 им. проф. С.В. Очаповского» Минздрава Краснодарского края; ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияKuban State Medical University; Prof. S.V. Ochapovsky Scientific and Research Institute – Krasnodar Regional Clinical Hospital No. 1; Rostov State Medical UniversityRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian FederationФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница №1 им. проф. С.В. Очаповского» Минздрава Краснодарского краяРоссияKuban State Medical University; Prof. S.V. Ochapovsky Scientific and Research Institute – Krasnodar Regional Clinical Hospital No. 1Russian Federation202030062020826777Copyright © Медведев В.Л., Коган М.И., Михайлов И.В., Лепетунов С.Н., 20202020Медведев В.Л., Коган М.И., Михайлов И.В., Лепетунов С.Н.Medvedev V.L., Kogan M.I., Mihailov I.V., Lepetunov S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/332

Аутологичная плазма обогащённая тромбоцитами (АПОТ/PRP) часто используется в различных отраслях медицины. Сфера применения PRP-терапии расширилась от стимуляции регенерации костей, заживления ран и язв, скелетно-мышечных травм до повышения возможностей в приживлении различных видов трансплантатов. Благодаря природным свойствам плазмы обогащённой тромбоцитами введение её в организм человека является одной из перспективных процедур в восстановлении тканей. После разрушения тромбоцитов АПОТ содержит α-гранулы, из которых после активации высвобождается множество факторов, таких как трансформирующий фактор роста-бета (TGF-β), фактор роста эндотелия сосудов (VGFF) и эпидермальный фактор роста (EGF). Нынешнее состояние проблемы использования АПОТ несёт в себе огромную перспективу по развитию методологии, которая обусловлена многими аспектами, делающими эту процедуру простой. АПОТ может улучшить течение множества урологических заболеваний, таких как эректильная дисфункция, болезнь Пейрони, стриктурная болезнь уретры, пузырно-влагалищные свищи, интерстициальный цистит и стрессовое недержание мочи. Существует множество протоколов для подготовки АПОТ, каждый из которых имеет свои стандартизированные параметры и заявленные результаты. В статье представлен обзор литературы по применению плазмы обогащённой тромбоцитами в урологии, фокусируется внимание на определении АПОТ, различных методах подготовки и активации, а также концентрации факторов роста.

Platelet-rich autologous plasma (PRP) is often used in various branches of medicine. The scope of PRP therapy has expanded from stimulating bone regeneration, healing wounds and ulcers, and musculoskeletal injuries to improving the ability to engrave various types of grafts. Due to the natural properties of platelet-rich plasma, its introduction into the human body is one of the most promising procedures for tissue restoration. After the destruction of platelets, PRP contains α-granules, from which many factors are released after activation, such as transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VGFF) and epidermal growth factor (EGF). The current state of the problem of using APOT has a huge perspective on the development of the methodology, which is due to many aspects that make this procedure simple. PRP can improve the course of many urological diseases, such as erectile dysfunction, Peyronie’s disease, urethral stricture, vesicovaginal fistulas, interstitial cystitis, and stress urinary incontinence. There are many protocols for preparing PRP, each of which has its standardized parameters and stated results. The article presents a review of the literature on the use of platelet-rich plasma in urology, focuses on the definition of PRP, various methods of preparation and activation, as well as the concentration of growth factors.

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The authors declare that there are no conflicts of interest present.