<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urovest</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник урологии</journal-title><trans-title-group xml:lang="en"><trans-title>Urology Herald</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2308-6424</issn><publisher><publisher-name>Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2308-6424-2018-6-4-21-26</article-id><article-id custom-type="elpub" pub-id-type="custom">urovest-232</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Результаты лечения эректильной дисфункции у пациентов после трансплантации почки в зависимости от вида сосудистого анастомоза</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of erectile dysfunction in patients after kidney transplantation depending on type of vascular anastomosis: results of short-term follow up study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6359-5932</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загитов</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagitov</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загитов Артур Раусович – д.м.н., профессор; профессор кафедры урологии.</p></bio><bio xml:lang="en"><p>Arthur R. Zagitov – M.D., Ph.D., Full Professor; Professor, Department of Urology.</p></bio><email xlink:type="simple">artur.zagitov@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5164-985X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухамедьянов</surname><given-names>Ф. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhamedyanov</surname><given-names>F. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухамедьянов Фаил Низаметдинович – аспирант кафедры урологии.</p></bio><bio xml:lang="en"><p>Fail N. Mukhamedyanov – Postgraduate Student, Department of Urology.</p></bio><email xlink:type="simple">muchamedianov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8461-9243</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Измайлов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Izmailov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Измайлов Адель Альбертович – д.м.н.; профессор кафедры урологии.</p></bio><bio xml:lang="en"><p>Adel A. Izmailov – M.D., Ph.D., Full Professor; Professor, Department of Urology.</p></bio><email xlink:type="simple">izmailov75@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кутлияров</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kutliyarov</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кутлияров Линат Миниханович – к.м.н., ассистент кафедры урологии.</p></bio><bio xml:lang="en"><p>Linat M. Kutliyarov – assistant of the department of Urology.</p><p>Ufa.</p></bio><email xlink:type="simple">lkutliyarov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2125-4897</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павлов Валентин Николаевич – Член-корр. РАН, д.м.н., профессор; ректор, заведующий кафедрой урологии.</p></bio><bio xml:lang="en"><p>Valentin N. Pavlov – M.D., Ph.D., Corresponding Member of Russian Academy of Sciences, Full Professor; Chancellor, Head of the Department of Urology.</p></bio><email xlink:type="simple">vpavlov3@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Башкирский государственный медицинский университет» МЗ РФ.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>21</day><month>02</month><year>2019</year></pub-date><volume>6</volume><issue>4</issue><fpage>21</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Загитов А.Р., Мухамедьянов Ф.Н., Измайлов А.А., Кутлияров Л.М., Павлов В.Н., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Загитов А.Р., Мухамедьянов Ф.Н., Измайлов А.А., Кутлияров Л.М., Павлов В.Н.</copyright-holder><copyright-holder xml:lang="en">Zagitov A.R., Mukhamedyanov F.N., Izmailov A.A., Kutliyarov L.M., Pavlov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.urovest.ru/jour/article/view/232">https://www.urovest.ru/jour/article/view/232</self-uri><abstract><p>Введение. Распространённость эректильной дисфункции (ЭД) у мужчин с хронической болезнью почек (ХБП) V стадии составляет от 60 до 80%. В тоже время распространённость ЭД у пациентов после трансплантации почек (ТП) сохраняется на высоком уровне до 60%. Одной из возможных причин развития ЭД после ТП, считают снижение артериального притока к кавернозным телам полового члена.Цель исследования. Оценить результаты лечения ЭД у пациентов после ТП в зависимости от вида сосудистого анастомоза.Материалы и методы. Обследовано 84 пациента с функционирующим трансплантатом почки. Все пациенты были разделены на 3 группы: I группа – 38 пациентов перенёсших ТП с анастомозом с внутренней подвздошной артерией (ВПА); II группа – 46 пациентов перенёсших ТП артериальным анастомозом с наружной подвздошной артерией (НПА); III группа – 35 здоровых добровольцев (контрольная группа), не имеющих в анамнезе урологических заболеваний и хирургических вмешательств на органах малого таза. Для оценки эректильной функции (ЭФ) применяли шкалу Международного индекса эректильной функции (МИЭФ-5). Ультразвуковое исследование с допплерографией артерий полового члена выполняли до и после интракавернозной фармакологической нагрузки. В лечении ЭД у пациентов после ТП использовали ингибиторы ФДЭ-5 (Тадалафил (Tadalafil) 5 мг ежедневно в течение 3-х месяцев, далее в дозе 20 мг «по требованию»), специальный комплекс упражнений для мышц дна таза, вакуум-терапию и физиолечение аппаратом «Андрогин».Результаты. По данные анкеты МИЭФ-5 значимые нарушения ЭФ выявлены у 26 (68,4%) пациентов I группы, и у 31 (73,9%) пациента II группы. К концу года лечения в I группе половой жизнью были удовлетворены 27 (71,1%) пациентов, во II группе – 39 (84,8%). По данным ультразвуковой допплерографии через 12 месяцев у пациентов I группы, максимальная систолическая скорость кровотока в правой и левой кавернозной артерии полового члена составила 25,0±3,44 см/с и 33,0±3,56 см/с соответственно. Разница артериального притока на 8 см/с говорит о выраженной артериальной недостаточности перфузии полового члена у пациентов I группы. При этом у пациентов II группы максимальная систолическая скорость оказалась достоверно выше, чем в I группе и составила 40,1±2,66см/с и 40,0±2,77 см/с соответственно.Выводы. Полученные данные свидетельствуют о снижении артериального притока к половому члену по правой кавернозной артерии у пациентов I группы, артериальный анастомоз трансплантата которым произведён с внутренней подвздошной артерией.</p></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The prevalence of erectile dysfunction in men with chronic kidney disease stage V is from 60 to 80%. At the same time, the prevalence of erectile dysfunction in patients after kidney transplantation remains high at up to 60%. One of the possible causes of erectile dysfunction after kidney transplantation is considered a decrease in arterial inflow to the cavernous bodies of the penis.</p></sec><sec><title>Objectives</title><p>Objectives. Тo evaluate the results of treatment of ED in patients after KT, depending on the vascular anastomosis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. 84 patients with a functioning kidney after transplantation were examined. All patients were divided into 3 groups: Group I – 38 patients undergoing KT with arterial vascular anastomosis with an internal iliac artery; Group II – 46 patients undergoing kidney transplantation with arterial vascular anastomosis to external iliac artery; Group III – 35 healthy volunteers (control group) with no history of urological diseases or surgical interventions on the pelvic organs. International Index of Erectile Function Index (IIEF-5) was used to assess erectile function. An ultrasound study with dopplerography of the penile arteries was performed before and after intracavernous pharmacological stress. For treating patients with erectile dysfunction after kidney transplantation were used PDE-5 inhibitors (Tadalafil® 5 mg daily for 3 months, then at a dose of 20 mg “on demand”), a special set of exercises for the muscles of the pelvic floor, vacuum therapy and physiotherapy with the device “Androgyne”.</p></sec><sec><title>Results</title><p>Results. Significant erectile function disorders were detected in 26 (68.4%) patients of group I, and in 31 (73.9%) patients of group II, according to data from the IIEF-5 questionnaire. Group I 27 (71.1%) patients were satisfied with sex life, group II – 39 (84.8%) by the end of the year. According to the Doppler ultrasound, after 12 months in patients of group I, the maximum systolic velocity of blood flow in the right and left cavernous artery of the penis was 25.0 ± 3.44 cm / s and 33.0 ± 3.56 cm / s, respectively. The difference in arterial inflow of 8 cm / s indicates a pronounced arterial perfusion of the penis in group I patients. At the same time, in patients of group II, the maximum systolic velocity was significantly higher than in group I and amounted to 40.1 ± 2.66 cm/s and 40.0 ± 2.77 cm/s, respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. The data obtained indicate a decrease in the arterial inflow to the penis along the right cavernous artery in patients from group I, who underwent an arterial vascular anastomosis with an internal iliac artery during kidney transplantation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эректильная дисфункция</kwd><kwd>хроническая болезнь почек</kwd><kwd>трансплантация почки</kwd><kwd>ультразвуковая допплерография сосудов полового члена</kwd></kwd-group><kwd-group xml:lang="en"><kwd>erectile disfunction</kwd><kwd>chronic kidney disease</kwd><kwd>kidney transplantation</kwd><kwd>doppler ultrasound of penile vessels</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki E, Nishimatsu H, Oba S, Takahashi M, Homma Y. Chronic kidney disease and erectile dysfunction. World J Nephrol. 2014;3(4):220-229. DOI: 10.5527/wjn.v3.i4.220</mixed-citation><mixed-citation xml:lang="en">Suzuki E, Nishimatsu H, Oba S, Takahashi M, Homma Y. Chronic kidney disease and erectile dysfunction. World J Nephrol. 2014;3(4):220-229. DOI: 10.5527/wjn.v3.i4.220</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mekki MO, El Hassan KA, El Mahdi EM, Haroun HH, Mohammed MA, Khamis KH, Ismail MO, Yousif ME, El Sanousi H. Prevalence and associated risk factors of male erectile dysfunction among patients on hemodialysis and kidney transplant recipients: a cross-sectional survey from Sudan. Saudi J Kidney Dis Transpl. 2013; 24(3):500-506. PMID: 23640621</mixed-citation><mixed-citation xml:lang="en">Mekki MO, El Hassan KA, El Mahdi EM, Haroun HH, Mohammed MA, Khamis KH, Ismail MO, Yousif ME, El Sanousi H. Prevalence and associated risk factors of male erectile dysfunction among patients on hemodialysis and kidney transplant recipients: a cross-sectional survey from Sudan. Saudi J Kidney Dis Transpl. 2013; 24(3):500-506. PMID: 23640621</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lasaponara F, Sedigh O, Pasquale G, Bosio A, Rolle L, Ceruti C, Timpano M, Negro CL, Paradiso M, Abbona A, Segoloni GP, Fontana D. Phosphodiesterase type 5 inhibitor treatment for erectile dysfunction in patients with end-stage renal disease receiving dialysis or after renal transplantation. J Sex Med. 2013;10(11):2798-2814. DOI: 10.1111/jsm.12038</mixed-citation><mixed-citation xml:lang="en">Lasaponara F, Sedigh O, Pasquale G, Bosio A, Rolle L, Ceruti C, Timpano M, Negro CL, Paradiso M, Abbona A, Segoloni GP, Fontana D. Phosphodiesterase type 5 inhibitor treatment for erectile dysfunction in patients with end-stage renal disease receiving dialysis or after renal transplantation. J Sex Med. 2013;10(11):2798-2814. DOI: 10.1111/jsm.12038</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Iglesias P, Carrero JJ, Díez JJ. Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options. J Nephrol. 2012;25(1):31-42. DOI: 10.5301/JN.2011.8481</mixed-citation><mixed-citation xml:lang="en">Iglesias P, Carrero JJ, Díez JJ. Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options. J Nephrol. 2012;25(1):31-42. DOI: 10.5301/JN.2011.8481</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, Lucisano G, Craig JC, Ruospo M, Gentile G, Manfreda VM, Querques M, Stroumza P, Torok M, Celia E, Gelfman R, Ferrari JN, Bednarek-Skublewska A, Dulawa J, Bonifati C, Hegbrant J, Wollheim C, Jannini EA, Strippoli GF. Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis. 2010;56(4):670-85. DOI: 10.1053/j.ajkd.2010.06.016</mixed-citation><mixed-citation xml:lang="en">Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, Lucisano G, Craig JC, Ruospo M, Gentile G, Manfreda VM, Querques M, Stroumza P, Torok M, Celia E, Gelfman R, Ferrari JN, Bednarek-Skublewska A, Dulawa J, Bonifati C, Hegbrant J, Wollheim C, Jannini EA, Strippoli GF. Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis. 2010;56(4):670-85. DOI: 10.1053/j.ajkd.2010.06.016</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Barroso LV, Miranda EP, Cruz NI, Medeiros MA, Araújo AC, Mota Filho FH, Medeiros FC. Analysis of sexual function in kidney transplanted men. Transplant Proc. 2008;40(10):3489-3491. DOI: 10.1016/j.transproceed.2008.07.141</mixed-citation><mixed-citation xml:lang="en">Barroso LV, Miranda EP, Cruz NI, Medeiros MA, Araújo AC, Mota Filho FH, Medeiros FC. Analysis of sexual function in kidney transplanted men. Transplant Proc. 2008;40(10):3489-3491. DOI: 10.1016/j.transproceed.2008.07.141</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer BF, Clegg DJ. Gonadal dysfunction in chronic kidney disease. Rev Endocr Metab Disord. 2017;18(1):117-130. DOI: 10.1007/s11154-016-9385-</mixed-citation><mixed-citation xml:lang="en">Palmer BF, Clegg DJ. Gonadal dysfunction in chronic kidney disease. Rev Endocr Metab Disord. 2017;18(1):117-130. DOI: 10.1007/s11154-016-9385-</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Antonucci M, Palermo G, Recupero SM, Bientinesi R, Presicce F, Foschi N, Bassi P, Gulino G. Male sexual dysfunction in patients with chronic end-stage renal insufficiency and in renal transplant recipients. Arch Ital Urol Androl. 2016;87(4):299-305. DOI: 10.4081/aiua.2015.4.299</mixed-citation><mixed-citation xml:lang="en">Antonucci M, Palermo G, Recupero SM, Bientinesi R, Presicce F, Foschi N, Bassi P, Gulino G. Male sexual dysfunction in patients with chronic end-stage renal insufficiency and in renal transplant recipients. Arch Ital Urol Androl. 2016;87(4):299-305. DOI: 10.4081/aiua.2015.4.299</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">El-Bahnasawy MS, El-Assmy A, Dawood A, Abobieh E, Dein BA, El-Din AB, El-Hamady Sel-D. Eff ect of the use of internal iliac artery for renal transplanta???? on of penile vascularity and erec???? le func???? on: a prospec???? ve study. J Urol. 2004;172(6 Pt 1):2335-2339. PMID: 15538261</mixed-citation><mixed-citation xml:lang="en">El-Bahnasawy MS, El-Assmy A, Dawood A, Abobieh E, Dein BA, El-Din AB, El-Hamady Sel-D. Eff ect of the use of internal iliac artery for renal transplanta???? on of penile vascularity and erec???? le func???? on: a prospec???? ve study. J Urol. 2004;172(6 Pt 1):2335-2339. PMID: 15538261</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shamsa A, Motavalli SM, Aghdam B. Erectile function in endstage renal disease before and after renal transplantation. Transplant Proc 2005;37(7):3087-3089. DOI: 10.1016/j.transproceed.2005.08.067</mixed-citation><mixed-citation xml:lang="en">Shamsa A, Motavalli SM, Aghdam B. Erectile function in endstage renal disease before and after renal transplantation. Transplant Proc 2005;37(7):3087-3089. DOI: 10.1016/j.transproceed.2005.08.067</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
