urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2018-6-1-65-75urovest-193Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL CASESЛЕЧЕНИЕ МЕТАСТАТИЧЕСКОГО РАКА ПРОСТАТЫ С ПОМОЩЬЮ ЛЮТЕЦИЙ-177-ПСМА — ПРИМЕРЫ СЛУЧАЕВ УДИВИТЕЛЬНЫХ РЕАКЦИЙLU-177-PSMA TREATMENT FOR METASTATIC PROSTATE CANCER – CASE EXAMPLES OF MIRACLE RESPONSEShttps://orcid.org/0000-0002-5194-746XКайремоК.KairemoK.

отделение ядерной медицины и молекулярной радиотерапии,

Хельсинки

Department of Molecular Radiotherapy and Nuclear Medicine,

Helsinki

kalevi.kairemo@docrates.comhttps://orcid.org/0000-0002-0455-8031ЙоэнсууТ.JoensuuT.

отделение медицинской онкологии и радиотерапии, 

Хельсинки

Department of Medical Oncology and Clinical Radiotherapy,

Helsinki

Онкологическая клиника ДократесФинляндияDocrates Cancer CenterFinland201831032018616575Copyright © Кайремо К., Йоэнсуу Т., 20182018Кайремо К., Йоэнсуу Т.Kairemo K., Joensuu T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/193

Простат специфическиймембранный антиген (ПСМА) экспрессируется при неблагоприятномтечении рака простаты. ПСМА является основой для новых методов диагностики и тераностики. Терапия радиолигандом 177Lu-ПСМА в основномиспользуется у пациентов с распространённой формой рака простаты. Это сообщение описывает двух пациентов: первый — с обширным метастатическим поражением, выявленным на первом визите, второй — с множественными рецидивами. Оба пациента были пролечены радиолигандом 177Lu-ПСМА с существенным ответом, то есть полной реакцией, подтверждённой методами визуализации и значительным снижением уровня ПСА. Терапия радиолигандом 177Lu-ПСМА имеет умеренные побочные эффекты. Пациенты с метастатическим раком простаты, подвергнутые терапии радиолигандом 177Lu-ПСМА-617 имели благоприятный терапевтический профиль, который был скорректирован в соответствии с потребностями пациента.

Prostate specific membrane antigen (PSMA) is expressed in unfavorable prostate cancer. PSMA is basis for new diagnostics and theranostics. 177Lu-PSMA radioligand therapy is mainly used for patients with endstage prostate cancer. This report describes two patients: one patient with a multiple recurrences and one with extensive metastastic disease during the first visit. Both these patients were treated with 177Lu-PSMA radioligand therapy with major response, i.e. complete response by imaging and substantial reduction of PSA. 177Lu-PSMA radioligand therapy gave only mild adverse effects. In conclusion, patients with metastatic prostate cancer, 177Lu-PSMA-617 radioligand therapy had an attractive therapeutic profile which had to be adjusted according to the patient´s need.

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The authors declare that there are no conflicts of interest present.