urovestВестник урологииUrology Herald2308-6424Rostov State Medical University10.21886/2308-6424-2017-5-4-69-78urovest-180Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS ARTICLEПРОСТАТИТ: ЧТО НОВОГО И ПОЛЕЗНОГО В ФУНДАМЕНТАЛЬНЫХ И КЛИНИЧЕСКИХ ИССЛЕДОВАНИЯХ?PROSTATITIS: WHAT’S NEW IN BASIC SCIENCE AND CLINICAL STUDIES?https://orcid.org/0000-0002-0657-5601ЛокшинК. Л.LokshinK. L.

доктор медицинских наук, заведующий отделением урологии,

Москва

MD, Head of Urology Department, 

Moscow

k_lokshin@hotmail.comКлинический госпиталь Лапино, ГК «Мать и дитя»РоссияClinical Hospital Lapino, Mother and Child Group of CompaniesRussian Federation201731122017546978Copyright © Локшин К.Л., 20182018Локшин К.Л.Lokshin K.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.urovest.ru/jour/article/view/180

В основу данного обзора литературы лег анализ более 600 работ, опубликованных в базе данных Pubmed в период с 2014 по 2016 гг. и посвященных исследованию простатита и синдрома хронической тазовой боли у мужчин. Представлены современные данные по эпидемиологии и патофизиологии хронического простатита/синдрома хронической тазовой боли (ХП/СХТБ). Продемонстрированы возможные взаимосвязи развития заболевания с образом жизни, с уровнем тестостерона крови, с генетическими факторами и с наличием атипических возбудителей (хламидий, гениальной микоплазмы). Ряд исследований показал изменения микробиоты у пациентов с ХП/СХТБ. Определены взаимосвязи ХП/СХТБ и патоспермии, ХП/СХТБ и сексуальной дисфункции. Ряд рассматриваемых работ посвящен фенотипированню пациентов с ХП/СХТБ по системе UPOINT, особенностям антибактериальной терапии в условяих растущей антибиотикорезистентности, возможностям нетрадиционных/немедикаментозных методов лечения и принципам мультимодальной терапии.

This review is based on analysis of more than 600 studies on prostatitis/chronic pelvic pain syndrome in males published in PubMed from Jan 2014 till December 2016. We present current data on epidemiology and pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Strong relationships have been shown between CP/CPPS and life style, blood testosterone, genetic factors and atypical intracellular pathogens (i.e. Chlamidia and Mycoplasma). In CP/CPPS patients significant microbiota alterations have been revealed. Also current data shows that CP|CPPS has a significant association with sperm count abnormalities and sexual dysfunction. Several studies confirmed UPIONT system to be a valuable tool in phenotyping of CP/ CPPS patients with further tailoring of multimodal treatment. Current trends and in antibacterial treatments and overcoming of bacterial resistance are demonstrated, as well as new data on efficacy of acupuncture, pollen extract and shock wave lithotripsy.

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The authors declare that there are no conflicts of interest present.