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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">urovest</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник урологии</journal-title><trans-title-group xml:lang="en"><trans-title>Urology Herald</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2308-6424</issn><publisher><publisher-name>Rostov State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2308-6424-2025-13-2-119-122</article-id><article-id custom-type="elpub" pub-id-type="custom">urovest-1060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Редкий случай метастазирования семиномы в мочевой пузырь</article-title><trans-title-group xml:lang="en"><trans-title>A rare case of seminoma metastasis to the bladder</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-9636-877X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аль-Тавил</surname><given-names>Мухамад</given-names></name><name name-style="western" xml:lang="en"><surname>Al-Tawil</surname><given-names>Muhamad</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухамад Аль-Тавил — доктор медицины, доктор философии, доцент </p><p>Дамаск </p></bio><bio xml:lang="en"><p>Muhamad Al-Tawil — MD, PhD, Assoc.Prof.  </p><p>Damascus </p></bio><email xlink:type="simple">muhamad.tawil@damascusuniversity.edu.sy</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Университет Дамаска, Факультет медицины</institution><country>Сирия</country></aff><aff xml:lang="en"><institution>Damascus University, Faculty of Medicine</institution><country>Syrian Arab Republic</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>08</day><month>06</month><year>2025</year></pub-date><volume>13</volume><issue>2</issue><fpage>119</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аль-Тавил М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Аль-Тавил М.</copyright-holder><copyright-holder xml:lang="en">Al-Tawil M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.urovest.ru/jour/article/view/1060">https://www.urovest.ru/jour/article/view/1060</self-uri><abstract><p>Введение. Подавляющее большинство опухолей тестикул являются опухолями зародышевых клеток (germ cells). Наиболее распространённой областью метастазирования данного типа опухолей является забрюшинное пространство. Метастазы в мочевой пузырь встречаются очень редко.Презентация наблюдения. Мужчина 33 лет, курящий, два года назад перенёс правостороннюю радикальную орхиэктомию по поводу семиномы. В периоперацинном периоде обследования выявлено увеличение правых забрюшинных и подвздошных лимфоузлов, а также правосторонний почечный гидронефроз. Была установлена нефростома, проведена химиотерапия, которая показала хороший ответ. Два года спустя пациент поступил с жалобами на боли в правом боку, гематурию и симптомы со стороны нижних мочевыводящих путей. По данным магнитно-резонансной томографии определено большое образование мочевого пузыря. После проведения цистоскопии и трансуретральной резекции было выявлено, что это метастатическая семинома.Обсуждение. Опухоли яичек являются наиболее распространённой злокачественной опухолью у мужчин в возрасте от 15 до 35 лет. Подавляющее большинство опухолей яичек — это опухоли зародышевых клеток (germ cells), а семиномы являются наиболее распространённым типом в данной группе. Метастазы в мочевую систему встречаются довольно редко.Заключение. Всегда следует учитывать редкие и поздние метастазы в мочевой пузырь, а также тщательно собирать анамнез.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. The great majority of testis neoplasms are germ cell tumours. The most common site of metastasis is the retroperitoneal region. Metastasis to the bladder is very rare.Clinical case. A 33-year-old male smoker had right radical orchiectomy two years ago for seminoma. The investigations then showed right retroperitoneal and iliac enlarged nodes and right renal hydronephrosis. Nephrostomy tube was inserted, chemotherapy was given with good response. Two years later the patient presented with right flank pain, hematuria and lower urinary tract symptoms. MRI showed a big bladder mass. Cystoscopy and transurethral resection were done and showed metastatic seminoma.Discussion. Testicular tumours are the most common male malignant neoplasms between the ages of 15 and 35 years. The great majority of testicular neoplasms are germ cell tumours and seminomas are the most common type of this group. Urinary system metastasis is quite rare. Conclusion. Rare and late metastases to the bladder should always be considered, and careful medical history should be taken.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>опухоли зародышевых клеток</kwd><kwd>семинома</kwd><kwd>метастазы в мочевой пузырь</kwd></kwd-group><kwd-group xml:lang="en"><kwd>germ cell tumours</kwd><kwd>seminoma</kwd><kwd>bladder metastases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Znaor A, Skakkebaek NE, Rajpert-De Meyts E, Kuliš T, Laversanne M, Gurney J, Sarfati D, McGlynn KA, Bray F. Global patterns in testicular cancer incidence and mortality in 2020. Int J Cancer. 2022;151(5):692- 698. DOI: 10.1002/ijc.33999</mixed-citation><mixed-citation xml:lang="en">Znaor A, Skakkebaek NE, Rajpert-De Meyts E, Kuliš T, Laversanne M, Gurney J, Sarfati D, McGlynn KA, Bray F. Global patterns in testicular cancer incidence and mortality in 2020. Int J Cancer. 2022;151(5):692- 698. DOI: 10.1002/ijc.33999</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Richie JP, Steele GS. Neoplasms of the testis. In: Kavaoussi LR, Novick AC, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 9th ed. Philadelphia: Saunders; 2007.</mixed-citation><mixed-citation xml:lang="en">Richie JP, Steele GS. Neoplasms of the testis. In: Kavaoussi LR, Novick AC, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 9th ed. Philadelphia: Saunders; 2007.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007;14(2):69-92. DOI: 10.1097/PAP.0b013e31803240e6</mixed-citation><mixed-citation xml:lang="en">McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007;14(2):69-92. DOI: 10.1097/PAP.0b013e31803240e6</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Husband JE, Bellamy EA. Unusual thoracoabdominal sites of metastases in testicular tumors. AJR Am J Roentgenol. 1985;145(6):1165-1171. DOI: 10.2214/ajr.145.6.1165</mixed-citation><mixed-citation xml:lang="en">Husband JE, Bellamy EA. Unusual thoracoabdominal sites of metastases in testicular tumors. AJR Am J Roentgenol. 1985;145(6):1165-1171. DOI: 10.2214/ajr.145.6.1165</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res. 2000;60(6):1475-1482. PMID: 10749107.</mixed-citation><mixed-citation xml:lang="en">Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res. 2000;60(6):1475-1482. PMID: 10749107.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Einhorn LH. Testicular cancer as a model for a curable neoplasm: The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 1981;41(9 Pt 1):3275-3280. PMID: 6167346.</mixed-citation><mixed-citation xml:lang="en">Einhorn LH. Testicular cancer as a model for a curable neoplasm: The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 1981;41(9 Pt 1):3275-3280. PMID: 6167346.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP; European Association of Urology. EAU guidelines on testicular cancer: 2011 update. Eur Urol. 2011;60(2):304- 319. DOI: 10.1016/j.eururo.2011.05.038</mixed-citation><mixed-citation xml:lang="en">Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP; European Association of Urology. EAU guidelines on testicular cancer: 2011 update. Eur Urol. 2011;60(2):304- 319. DOI: 10.1016/j.eururo.2011.05.038</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Türkoğlu AR, Coban S, Guzelsoy M, Demirbas M, Mutlu N, Yalcin O. Rare late metastasis of testis seminoma to the bladder. Can Urol Assoc J. 2015;9(11-12):E823-E825. DOI: 10.5489/cuaj.3250</mixed-citation><mixed-citation xml:lang="en">Türkoğlu AR, Coban S, Guzelsoy M, Demirbas M, Mutlu N, Yalcin O. Rare late metastasis of testis seminoma to the bladder. Can Urol Assoc J. 2015;9(11-12):E823-E825. DOI: 10.5489/cuaj.3250</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gürbüz YS, Müezzinoglu B, Cimen K, Dillioglugil O. Synchronous occurrence of bladder carcinosarcoma and testicular seminoma. Int J Urol. 2001;8(7):404-407. DOI: 10.1046/j.1442-2042.2001.00322.x</mixed-citation><mixed-citation xml:lang="en">Gürbüz YS, Müezzinoglu B, Cimen K, Dillioglugil O. Synchronous occurrence of bladder carcinosarcoma and testicular seminoma. Int J Urol. 2001;8(7):404-407. DOI: 10.1046/j.1442-2042.2001.00322.x</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Alsolami A, Alotaıbı M, Bazarbashı S, Almutawa A, Akhtar M. Seminoma presenting as a polypoid bladder mass: a case report. Turk Patoloji Derg. 2014;30(1):69-72. DOI: 10.5146/tjpath.2013.0120</mixed-citation><mixed-citation xml:lang="en">Alsolami A, Alotaıbı M, Bazarbashı S, Almutawa A, Akhtar M. Seminoma presenting as a polypoid bladder mass: a case report. Turk Patoloji Derg. 2014;30(1):69-72. DOI: 10.5146/tjpath.2013.0120</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nakatani T, Sugimura K, Naganuma T, Kamikawa S, Sugimoto T. Metastatic urinary bladder tumor from extragonadal germ cell tumor: a case report. Oncol Rep. 2002;9(6):1209-1211. PMID: 12375021.</mixed-citation><mixed-citation xml:lang="en">Nakatani T, Sugimura K, Naganuma T, Kamikawa S, Sugimoto T. Metastatic urinary bladder tumor from extragonadal germ cell tumor: a case report. Oncol Rep. 2002;9(6):1209-1211. PMID: 12375021.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Viddeleer AC, Lycklama à Nijeholt GA, Beekhuis-Brussee JA. A late manifestation of testicular seminoma in the bladder in a renal transplant recipient: a case report. J Urol. 1992;148(2 Pt 1):401-402. DOI: 10.1016/s0022-5347(17)36611-9</mixed-citation><mixed-citation xml:lang="en">Viddeleer AC, Lycklama à Nijeholt GA, Beekhuis-Brussee JA. A late manifestation of testicular seminoma in the bladder in a renal transplant recipient: a case report. J Urol. 1992;148(2 Pt 1):401-402. DOI: 10.1016/s0022-5347(17)36611-9</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Alsharif M, Aslan DL, Jessurun J, Gulbahce HE, Pambuccian SE. Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report. Diagn Cytopathol. 2008;36(10):734-738. DOI: 10.1002/dc.20881</mixed-citation><mixed-citation xml:lang="en">Alsharif M, Aslan DL, Jessurun J, Gulbahce HE, Pambuccian SE. Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report. Diagn Cytopathol. 2008;36(10):734-738. DOI: 10.1002/dc.20881</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Khandekar JD, Holland JM, Rochester D, Christ ML. Extragonadal seminoma involving urinary bladder and arising in the prostate. Cancer. 1993;71(12):3972-3974. DOI: 10.1002/1097-0142(19930615)71:12&lt;3972::aid-cncr2820711228&gt;3.0.co;2-p</mixed-citation><mixed-citation xml:lang="en">Khandekar JD, Holland JM, Rochester D, Christ ML. Extragonadal seminoma involving urinary bladder and arising in the prostate. Cancer. 1993;71(12):3972-3974. DOI: 10.1002/1097-0142(19930615)71:12&lt;3972::aid-cncr2820711228&gt;3.0.co;2-p</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hashimoto T, Ohori M, Sakamoto N, Matsubayashi J, Izumi M, Tachibana M. Primary seminoma of the prostate. Int J Urol. 2009;16(12):967- 970. DOI: 10.1111/j.1442-2042.2009.02403.x</mixed-citation><mixed-citation xml:lang="en">Hashimoto T, Ohori M, Sakamoto N, Matsubayashi J, Izumi M, Tachibana M. Primary seminoma of the prostate. Int J Urol. 2009;16(12):967- 970. DOI: 10.1111/j.1442-2042.2009.02403.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
